APR-246/PRIMA-1MET rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations

Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome

(2012) Giustina Ferone et al.   EMBO Molecular Medicine

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

(2012) Sören Lehmann et al.   JOURNAL OF CLINICAL ONCOLOGY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

p63, a Story of Mice and Men

(2011) Hans Vanbokhoven et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Embryonic stem cells as an ectodermal cellular model of human p63-related dysplasia syndromes

(2010) Philippe Rostagno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rapp-Hodgkin and Hay-Wells ectodermal dysplasia syndromes represent a variable spectrum of the same genetic disorder

(2010) S.E. Clements et al.   BRITISH JOURNAL OF DERMATOLOGY

The retinal dehydrogenase/reductaseretSDR1/DHRS3gene is activated by p53 and p63 but not by mutants derived from tumors or EEC/ADULT malformation syndromes

(2010) Ralf D. Kirschner et al.   CELL CYCLE

ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis

(2010) R Shalom-Feuerstein et al.   CELL DEATH AND DIFFERENTIATION

PRIMA-1MET/APR-246 targets mutant forms of p53 family members p63 and p73

(2010) N Rökaeus et al.   ONCOGENE

Pharmacological reactivation of mutant p53: from protein structure to the cancer patient

(2010) K G Wiman   ONCOGENE

Genome-Wide Profiling of p63 DNA–Binding Sites Identifies an Element that Regulates Gene Expression during Limb Development in the 7q21 SHFM1 Locus

(2010) Evelyn N. Kouwenhoven et al.   PLoS Genetics

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

Restoration of p53 to limit tumor growth

(2009) Wenge Wang et al.   CURRENT OPINION IN ONCOLOGY

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects

(2008) N. Lo Iacono et al.   DEVELOPMENT

Claudin-1 Is a p63 Target Gene with a Crucial Role in Epithelial Development

(2008) Teresa Lopardo et al.   PLoS One