Structure, function and selective inhibition of bacterial acetyl-coa carboxylase

Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

(2011) Joshua B Parsons et al.   CURRENT OPINION IN MICROBIOLOGY

Structural and Biochemical Studies on the Regulation of Biotin Carboxylase by Substrate Inhibition and Dimerization

(2011) Chi-Yuan Chou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current understanding of fatty acid biosynthesis and the acyl carrier protein

(2010) David I. Chan et al.   BIOCHEMICAL JOURNAL

Crystal Structures and Mutational Analyses of Acyl-CoA Carboxylase β Subunit ofStreptomyces coelicolor,

(2010) Ana Arabolaza et al.   BIOCHEMISTRY

Antibiotic discovery in the twenty-first century: current trends and future perspectives

(2010) Stefano Donadio et al.   JOURNAL OF ANTIBIOTICS

Community-associated methicillin-resistant Staphylococcus aureus immune evasion and virulence

(2010) Shawna F. Graves et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Community-associated meticillin-resistant Staphylococcus aureus

(2010) Frank R DeLeo et al.   LANCET

Essentiality of FASII pathway for Staphylococcus aureus

(2010) Wendy Balemans et al.   NATURE

Mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxaden

(2010) L. P. C. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis

(2010) C.-W. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches

(2009) Igor Mochalkin et al.   ACS Chemical Biology

The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist

(2009) Kevin P. Madauss et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK

(2009) Yong Soon Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery and optimization of antibacterial AccC inhibitors

(2009) Cliff C. Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein kinases as antibacterial targets

(2009) Mark Schreiber et al.   CURRENT OPINION IN CELL BIOLOGY

Crystal Structure of Biotin Carboxylase in Complex with Substrates and Implications for Its Catalytic Mechanism

(2009) Chi-Yuan Chou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria

(2009) D. G. Kurth et al.   MICROBIOLOGY-SGM

A tale of two functions: enzymatic activity and translational repression by carboxyltransferase

(2009) Glen Meades et al.   NUCLEIC ACIDS RESEARCH

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

(2009) J. Richard Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim

(2009) S. Xiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

ATP competitive inhibitors of d-alanine–d-alanine ligase based on protein kinase inhibitor scaffolds

(2008) Gemma Triola et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase

(2008) Igor Mochalkin et al.   PROTEIN SCIENCE

MICROBIOLOGY: Desperately Seeking New Antibiotics

(2008) D. J. Payne   SCIENCE