The Receptor Tyrosine Kinase AXL in Cancer Progression

Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

(2016) Le Qu et al.   CANCER CELL

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

(2016) Christopher J. Tape et al.   CELL

Development and maturation of natural killer cells

(2016) Theresa L Geiger et al.   CURRENT OPINION IN IMMUNOLOGY

Strong Expression of Hypoxia-Inducible Factor-1α (HIF-1α) Is Associated with Axl Expression and Features of Aggressive Tumors in African Breast Cancer

(2016) Hawa Nalwoga et al.   PLoS One

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance

(2016) M. A. Miller et al.   Cancer Discovery

The AXL receptor tyrosine kinase is associated with adverse prognosis and distant metastasis in esophageal squamous cell carcinoma

(2016) Min-Shu Hsieh et al.   Oncotarget

Axl Expression Stratifies Patients with Poor Prognosis after Hepatectomy for Hepatocellular Carcinoma

(2016) Jian Liu et al.   PLoS One

Relationship Between Increased Expression of the Axl/Gas6 Signal Cascade and Prognosis of Patients with Upper Tract Urothelial Carcinoma

(2015) Seiya Hattori et al.   ANNALS OF SURGICAL ONCOLOGY

Prostaglandin E synthase is upregulated by Gas6 during cancer-induced venous thrombosis

(2015) M. N. Aghourian et al.   BLOOD

AXL Mediates Resistance to PI3Kα Inhibition by Activating the EGFR/PKC/mTOR Axis in Head and Neck and Esophageal Squamous Cell Carcinomas

(2015) Moshe Elkabets et al.   CANCER CELL

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma

(2015) T. M. Brand et al.   CLINICAL CANCER RESEARCH

Multicenter analysis of soluble Axl reveals diagnostic value for very early stage hepatocellular carcinoma

(2015) Patrick Reichl et al.   INTERNATIONAL JOURNAL OF CANCER

Inactivation of GSK3β and activation of NF-κB pathway via Axl represents an important mediator of tumorigenesis in esophageal squamous cell carcinoma

(2015) Juliano D. Paccez et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma

(2015) L Zhou et al.   ONCOGENE

Polarization of tumor-associated macrophages and Gas6/Axl signaling in oral squamous cell carcinoma

(2015) Kuo-Chou Chiu et al.   ORAL ONCOLOGY

MiR-34a suppresses ovarian cancer proliferation and motility by targeting AXL

(2015) Rui Li et al.   TUMOR BIOLOGY

Novel Axl-driven signaling pathway and molecular signature characterize high-grade ovarian cancer patients with poor clinical outcome

(2015) Katia Rea et al.   Oncotarget

Kinome-wide shRNA Screen Identifies the Receptor Tyrosine Kinase AXL as a Key Regulator for Mesenchymal Glioblastoma Stem-like Cells

(2015) Peng Cheng et al.   Stem Cell Reports

Soluble AXL: A Possible Circulating Biomarker for Neurofibromatosis Type 1 Related Tumor Burden

(2015) Gunnar Johansson et al.   PLoS One

Elevated Serum Gas6 Is a Novel Prognostic Biomarker in Patients with Oral Squamous Cell Carcinoma

(2015) Tao Jiang et al.   PLoS One

AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs

(2014) C. Wilson et al.   CANCER RESEARCH

AXL Mediates Resistance to Cetuximab Therapy

(2014) T. M. Brand et al.   CANCER RESEARCH

Role of Growth arrest-specific gene 6-Mer axis in multiple myeloma

(2014) J S Waizenegger et al.   LEUKEMIA

Axl Phosphorylates Elmo Scaffold Proteins To Promote Rac Activation and Cell Invasion

(2014) Afnan Abu-Thuraia et al.   MOLECULAR AND CELLULAR BIOLOGY

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

(2014) Magdalena Paolino et al.   NATURE

An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis

(2014) Mihalis S Kariolis et al.   Nature Chemical Biology

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET

(2014) Erinn B. Rankin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-34a: a potential therapeutic target in human cancer

(2014) X J Li et al.   Cell Death & Disease

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

(2014) Judith Müller et al.   Nature Communications

A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

(2014) D. J. Konieczkowski et al.   Cancer Discovery

Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma

(2013) Pu-xiang Chen et al.   Annals of Diagnostic Pathology

Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients

(2013) Ju Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma

(2013) I. Ben-Batalla et al.   BLOOD

The expression of Axl receptor tyrosine kinase influences the tumour phenotype and clinical outcome of patients with malignant pleural mesothelioma

(2013) D J Pinato et al.   BRITISH JOURNAL OF CANCER

AXL Is a Key Regulator of Inherent and Chemotherapy-Induced Invasion and Predicts a Poor Clinical Outcome in Early-Stage Colon Cancer

(2013) P. D. Dunne et al.   CLINICAL CANCER RESEARCH

GAS6 expression identifies high-risk adult AML patients: potential implications for therapy

(2013) S P Whitman et al.   LEUKEMIA

Axl Mediates Acquired Resistance of Head and Neck Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Erlotinib

(2013) Keith M. Giles et al.   MOLECULAR CANCER THERAPEUTICS

Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival

(2013) S Ammoun et al.   ONCOGENE

AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells

(2013) M K Asiedu et al.   ONCOGENE

The receptor tyrosine kinase Axl regulates cell–cell adhesion and stemness in cutaneous squamous cell carcinoma

(2013) M A Cichoń et al.   ONCOGENE

The Receptor AXL Diversifies EGFR Signaling and Limits the Response to EGFR-Targeted Inhibitors in Triple-Negative Breast Cancer Cells

(2013) A. S. Meyer et al.   Science Signaling

Biology of the TAM Receptors

(2013) G. Lemke   Cold Spring Harbor Perspectives in Biology

Cabozantinib as a Novel Therapy for Renal Cell Carcinoma

(2013) Ulka Vaishampayan   Current Oncology Reports

Meta-Analysis of Microarray Data IdentifiesGAS6Expression as an Independent Predictor of Poor Survival in Ovarian Cancer

(2013) Michelle Buehler et al.   Biomed Research International

Higher Expression of Receptor Tyrosine Kinase Axl, and Differential Expression of its Ligand, Gas6, Predict Poor Survival in Lung Adenocarcinoma Patients

(2012) Masashi Ishikawa et al.   ANNALS OF SURGICAL ONCOLOGY

ABL Regulation by AXL Promotes Cisplatin Resistance in Esophageal Cancer

(2012) J. Hong et al.   CANCER RESEARCH

Hypoxia Stabilizes GAS6/Axl Signaling in Metastatic Prostate Cancer

(2012) Anjali Mishra et al.   MOLECULAR CANCER RESEARCH

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

(2012) Zhenfeng Zhang et al.   NATURE GENETICS

Axl Is a Prognostic Marker in Oral Squamous Cell Carcinoma

(2011) Chien-Hsing Lee et al.   ANNALS OF SURGICAL ONCOLOGY

Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA

(2011) Mark Mackiewicz et al.   BREAST CANCER RESEARCH AND TREATMENT

The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma

(2011) Alvarez Hector et al.   CANCER BIOLOGY & THERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer

(2011) G Mudduluru et al.   ONCOGENE

The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy

(2010) A. K. Ghosh et al.   BLOOD

Induction, regulation, and biologic function of Axl receptor tyrosine kinase in Kaposi sarcoma

(2010) R. Liu et al.   BLOOD

The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target

(2010) Jan-Bart M. Koorstra et al.   CANCER BIOLOGY & THERAPY

AXL Is an Essential Factor and Therapeutic Target for Metastatic Ovarian Cancer

(2010) E. B. Rankin et al.   CANCER RESEARCH

R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer

(2010) S. J. Holland et al.   CANCER RESEARCH

Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors

(2010) Rachel MA Linger et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Myeloid Zinc Finger 1 Induces Migration, Invasion, and In vivo Metastasis through Axl Gene Expression in Solid Cancer

(2010) G. Mudduluru et al.   MOLECULAR CANCER RESEARCH

AXL regulates mesothelioma proliferation and invasiveness

(2010) W-B Ou et al.   ONCOGENE

An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies

(2010) X Ye et al.   ONCOGENE

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6

(2009) S. Loges et al.   BLOOD

Differential Expression of Axl and Gas6 in Renal Cell Carcinoma Reflecting Tumor Advancement and Survival

(2009) A. Gustafsson et al.   CLINICAL CANCER RESEARCH

Lack of Protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis

(2009) Tal Burstyn-Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

(2009) C. Gjerdrum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human receptor tyrosine kinase Axl gene - promoter characterization and regulation of constitutive expression by Sp1, Sp3, and CpG methylation

(2008) Giridhar Mudduluru et al.   BIOSCIENCE REPORTS

The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development

(2008) I.-K. Park et al.   BLOOD

Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

(2008) Chih-Chen Hong et al.   CANCER LETTERS

Axl and Growth Arrest Specific Gene 6 Are Frequently Overexpressed in Human Gliomas and Predict Poor Prognosis in Patients with Glioblastoma Multiforme

(2008) M. Hutterer et al.   CLINICAL CANCER RESEARCH

Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-κB and Brg-1

(2008) K-Y Tai et al.   ONCOGENE