Axl Phosphorylates Elmo Scaffold Proteins To Promote Rac Activation and Cell Invasion

Dock4 forms a complex with SH3YL1 and regulates cancer cell migration

(2014) Masakazu Kobayashi et al.   CELLULAR SIGNALLING

Insights into the biological functions of Dock family guanine nucleotide exchange factors

(2014) M. Laurin et al.   GENES & DEVELOPMENT

G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates

(2014) N. Hamoud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila importin-7 functions upstream of the Elmo signaling module to mediate the formation and stability of muscle attachments

(2013) Z. C. Liu et al.   JOURNAL OF CELL SCIENCE

EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180

(2013) H Feng et al.   ONCOGENE

AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells

(2013) M K Asiedu et al.   ONCOGENE

Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis

(2013) M. Laurin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis

(2013) Hongyan Li et al.   Nature Communications

Blockade of Inflammatory Responses by a Small-Molecule Inhibitor of the Rac Activator DOCK2

(2012) Akihiko Nishikimi et al.   CHEMISTRY & BIOLOGY

ELMO Recruits Actin Cross-linking Family 7 (ACF7) at the Cell Membrane for Microtubule Capture and Stabilization of Cellular Protrusions

(2012) Yoran Margaron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAC1 activation mediates Twist1-induced cancer cell migration

(2012) Wen-Hao Yang et al.   NATURE CELL BIOLOGY

Twists and turns of invasion

(2012) Geoffrey Childs et al.   NATURE CELL BIOLOGY

Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

(2012) H. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Arf Family GTPase Arl4A Complexes with ELMO Proteins to Promote Actin Cytoskeleton Remodeling and Reveals a Versatile Ras-binding Domain in the ELMO Proteins Family

(2011) Manishha Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Rac1 by Src-dependent phosphorylation of Dock180Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

(2011) Haizhong Feng et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Axl and Mer Kinases in Cancer

(2011) A. Verma et al.   MOLECULAR CANCER THERAPEUTICS

R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer

(2010) S. J. Holland et al.   CANCER RESEARCH

DOCK180 Is a Rac Activator That Regulates Cardiovascular Development by Acting Downstream of CXCR4

(2010) Fumiyuki Sanematsu et al.   CIRCULATION RESEARCH

An Evolutionarily Conserved Autoinhibitory Molecular Switch in ELMO Proteins Regulates Rac Signaling

(2010) Manishha Patel et al.   CURRENT BIOLOGY

Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis

(2010) Nora B Caberoy et al.   EMBO JOURNAL

An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies

(2010) X Ye et al.   ONCOGENE

Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL

(2009) L. Liu et al.   CANCER RESEARCH

Identification of tubby and tubby-like protein 1 as eat-me signals by phage display

(2009) Nora B. Caberoy et al.   EXPERIMENTAL CELL RESEARCH

Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis

(2009) Y Li et al.   ONCOGENE

Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

(2009) C. Gjerdrum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth arrest-specific gene 6 expression in human breast cancer

(2008) O Mc Cormack et al.   BRITISH JOURNAL OF CANCER

AXL Is a Potential Target for Therapeutic Intervention in Breast Cancer Progression

(2008) Y.-X. Zhang et al.   CANCER RESEARCH

uPAR promotes formation of the p130Cas–Crk complex to activate Rac through DOCK180

(2008) Harvey W. Smith et al.   JOURNAL OF CELL BIOLOGY

In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation

(2008) Jason G. Weinger et al.   JOURNAL OF NEUROCHEMISTRY

An α-Helical Extension of the ELMO1 Pleckstrin Homology Domain Mediates Direct Interaction to DOCK180 and Is Critical in Rac Signaling

(2008) David Komander et al.   MOLECULAR BIOLOGY OF THE CELL

Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2

(2008) D. Jansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA