Nuclear Hormone Receptors Enable Macrophages and Dendritic Cells to Sense Their Lipid Environment and Shape Their Immune Response

Imprinting of CCR9 on CD4 T Cells Requires IL-4 Signaling on Mesenteric Lymph Node Dendritic Cells

(2014) R. Elgueta et al.   JOURNAL OF IMMUNOLOGY

1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells

(2014) A.-K. Shirakawa et al.   JOURNAL OF IMMUNOLOGY

Macrophages as APC and the Dendritic Cell Myth

(2014) D. A. Hume   JOURNAL OF IMMUNOLOGY

Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets

(2011) K. L. Wong et al.   BLOOD

Essential Role for Retinoic Acid in the Promotion of CD4+ T Cell Effector Responses via Retinoic Acid Receptor Alpha

(2011) Jason A. Hall et al.   IMMUNITY

Prostaglandin E2 suppresses the differentiation of retinoic acid–producing dendritic cells in mice and humans

(2011) Angus Stock et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peroxisome Proliferator-Activated Receptor  -Regulated Cathepsin D Is Required for Lipid Antigen Presentation by Dendritic Cells

(2011) B. Nakken et al.   JOURNAL OF IMMUNOLOGY

Expression of Retinaldehyde Dehydrogenase Enzymes in Mucosal Dendritic Cells and Gut-Draining Lymph Node Stromal Cells Is Controlled by Dietary Vitamin A

(2011) R. Molenaar et al.   JOURNAL OF IMMUNOLOGY

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens

(2011) R. W. DePaolo et al.   NATURE

The metabolic coregulator RIP140: an update

(2010) Asmaà Fritah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Skin-draining lymph nodes contain dermis-derived CD103- dendritic cells that constitutively produce retinoic acid and induce Foxp3+ regulatory T cells

(2010) M. Guilliams et al.   BLOOD

PML/RARα Targets Promoter Regions Containing PU.1 Consensus and RARE Half Sites in Acute Promyelocytic Leukemia

(2010) Kankan Wang et al.   CANCER CELL

Vitamin D Deficiency in Mice Impairs Colonic Antibacterial Activity and Predisposes to Colitis

(2010) Venu Lagishetty et al.   ENDOCRINOLOGY

STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells

(2010) Attila Szanto et al.   IMMUNITY

Activation of Liver X Receptor Sensitizes Human Dendritic Cells to Inflammatory Stimuli

(2010) D. Torocsik et al.   JOURNAL OF IMMUNOLOGY

Retinoic Acid-Induced CCR9 Expression Requires Transient TCR Stimulation and Cooperativity between NFATc2 and the Retinoic Acid Receptor/Retinoid X Receptor Complex

(2010) Y. Ohoka et al.   JOURNAL OF IMMUNOLOGY

Research Resource: Transcriptome Profiling of Genes Regulated by RXR and Its Permissive and Nonpermissive Partners in Differentiating Monocyte-Derived Dendritic Cells

(2010) Lajos Széles et al.   MOLECULAR ENDOCRINOLOGY

Activation of  -Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

(2010) S. Manicassamy et al.   SCIENCE

In vivo function of Langerhans cells and dermal dendritic cells

(2010) Daniel H. Kaplan   TRENDS IN IMMUNOLOGY

Induction of Transglutaminase 2 by a Liver X Receptor/Retinoic Acid Receptor α Pathway Increases the Clearance of Apoptotic Cells by Human Macrophages

(2009) Cédric Rébé et al.   CIRCULATION RESEARCH

Retinoic Acid Can Directly Promote TGF-β-Mediated Foxp3+ Treg Cell Conversion of Naive T Cells

(2009) Daniel Mucida et al.   IMMUNITY

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

(2009) Maria A. Curotto de Lafaille et al.   IMMUNITY

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

Retinoic acid contributes to the induction of IL-12-hypoproducing dendritic cells

(2009) Yasuyo Wada et al.   INFLAMMATORY BOWEL DISEASES

GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity

(2009) Aya Yokota et al.   INTERNATIONAL IMMUNOLOGY

Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease

(2009) Tian-Tian Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CX3CR1+CD115+CD135+common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

(2009) Cedric Auffray et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Contrasting roles for all-trans retinoic acid in TGF-β–mediated induction ofFoxp3andIl10genes in developing regulatory T cells

(2009) Craig L. Maynard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

1,25-Dihydroxyvitamin D3 Is an Autonomous Regulator of the Transcriptional Changes Leading to a Tolerogenic Dendritic Cell Phenotype

(2009) L. Szeles et al.   JOURNAL OF IMMUNOLOGY

Increased Antigen Cross-Presentation but Impaired Cross-Priming after Activation of Peroxisome Proliferator-Activated Receptor   Is Mediated by Up-Regulation of B7H1

(2009) L. Klotz et al.   JOURNAL OF IMMUNOLOGY

Pollen-Derived E1-Phytoprostanes Signal via PPAR-  and NF- B-Dependent Mechanisms

(2009) S. Gilles et al.   JOURNAL OF IMMUNOLOGY

Human CD14+ Macrophages in Intestinal Lamina Propria Exhibit Potent Antigen-Presenting Ability

(2009) N. Kamada et al.   JOURNAL OF IMMUNOLOGY

Lymph Node Stromal Cells Support Dendritic Cell-Induced Gut-Homing of T Cells

(2009) R. Molenaar et al.   JOURNAL OF IMMUNOLOGY

PPARγ regulates retinoic acid-mediated DC induction of Tregs

(2009) William J. Housley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Oxysterol signaling links cholesterol metabolism and inflammation via the liver X receptor in macrophages

(2009) Dániel Töröcsik et al.   MOLECULAR ASPECTS OF MEDICINE

Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses

(2009) Eduardo J Villablanca et al.   NATURE MEDICINE

Toll-like receptor 2–dependent induction of vitamin A–metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity

(2009) Santhakumar Manicassamy et al.   NATURE MEDICINE

Convergence of IL-1β and VDR Activation Pathways in Human TLR2/1-Induced Antimicrobial Responses

(2009) Philip T. Liu et al.   PLoS One

TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection

(2009) J. R. Aldridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Books Received

(2009)   SCIENCE

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

Applying a “Double-Feature” Promoter to Identify Cardiomyocytes Differentiated from Human Embryonic Stem Cells Following Transposon-Based Gene Delivery

(2009) Tamás I. Orbán et al.   STEM CELLS

Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome?

(2009) Anali Conesa-Botella et al.   AIDS Research and Therapy

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors

(2008) Cynthia Hong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Nuclear receptor signalling in dendritic cells connects lipids, the genome and immune function

(2008) Istvan Szatmari et al.   EMBO JOURNAL

Genome-wide profiling of PPAR :RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis

(2008) R. Nielsen et al.   GENES & DEVELOPMENT

PPAR  and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

(2008) M. I. Lefterova et al.   GENES & DEVELOPMENT

Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4+CD44hi Cells

(2008) Jonathan A. Hill et al.   IMMUNITY

The many faces of PPARγ: Anti-inflammatory by any means?

(2008) Attila Szanto et al.   IMMUNOBIOLOGY

Serum lipids regulate dendritic cell CD1 expression and function

(2008) David S. Leslie et al.   IMMUNOLOGY

Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis

(2008) K. E Nnoaham et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Small intestinal CD103+dendritic cells display unique functional properties that are conserved between mice and humans

(2008) Elin Jaensson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo

(2008) Swantje I. Hammerschmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPARγ:RXR heterodimers: comparison with other polyunsaturated fatty acids

(2008) Fernando Zapata-Gonzalez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Selected natural and synthetic retinoids impair CCR7- and CXCR4-dependent cell migration in vitro and in vivo

(2008) Eduardo J. Villablanca et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARγ−/−, PPARδ−/−, PPARγδ−/−, or LXRαβ−/−bone marrow

(2008) Chaitra Marathe et al.   JOURNAL OF LIPID RESEARCH

Structural Insight into PPARγ Activation Through Covalent Modification with Endogenous Fatty Acids

(2008) Tsuyoshi Waku et al.   JOURNAL OF MOLECULAR BIOLOGY

Retinoic acid prevents Chlamydia pneumoniae-induced foam cell development in a mouse model of atherosclerosis

(2008) Shinn-Jong Jiang et al.   MICROBES AND INFECTION

Integration of metabolism and inflammation by lipid-activated nuclear receptors

(2008) Steven J. Bensinger et al.   NATURE

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

(2008) Satoshi Uematsu et al.   NATURE IMMUNOLOGY

Immunology's foundation: the 100-year anniversary of the Nobel Prize to Paul Ehrlich and Elie Metchnikoff

(2008) Stefan H E Kaufmann   NATURE IMMUNOLOGY

Structural basis for the activation of PPARγ by oxidized fatty acids

(2008) Toshimasa Itoh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular recognition of nitrated fatty acids by PPARγ

(2008) Yong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The vitamin D receptor is required for iNKT cell development

(2008) Sanhong Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

L-arginine and vitamin D: novel adjunctive immunotherapies in tuberculosis

(2008) Anna P. Ralph et al.   TRENDS IN MICROBIOLOGY

Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity

(2008) John S Adams et al.   Nature clinical practice. Endocrinology & metabolism

Mechanisms of macrophage activation in obesity-induced insulin resistance

(2008) Justin I Odegaard et al.   Nature clinical practice. Endocrinology & metabolism

Control of autoimmune diseases by the vitamin D endocrine system

(2008) Luciano Adorini et al.   Nature clinical practice. Rheumatology

Homing imprinting and immunomodulation in the gut: Role of dendritic cells and retinoids

(2007) Rodrigo J. Mora   INFLAMMATORY BOWEL DISEASES

Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression

(2007) Kei-ichi Yamanaka et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY