TGF-β Signaling in Bone Remodeling and Osteosarcoma Progression

First human dose (FHD) study of the oral transforming growth factor-beta receptor I kinase inhibitor LY2157299 in patients with treatment-refractory malignant glioma.

(2017) J. Rodon Ahnert et al.   JOURNAL OF CLINICAL ONCOLOGY

Crosstalk between transforming growth factor-β signaling pathway and long non-coding RNAs in cancer

(2016) Jianbo Wang et al.   CANCER LETTERS

Agonists and Antagonists of TGF-β Family Ligands

(2016) Chenbei Chang   Cold Spring Harbor Perspectives in Biology

Signaling Receptors for TGF-β Family Members

(2016) Carl-Henrik Heldin et al.   Cold Spring Harbor Perspectives in Biology

TGF-β Signaling from Receptors to Smads

(2016) Akiko Hata et al.   Cold Spring Harbor Perspectives in Biology

An update on chemotherapy for osteosarcoma

(2015) Stefano Ferrari et al.   EXPERT OPINION ON PHARMACOTHERAPY

The immune suppressive function of transforming growth factor-β(TGF-β) in human diseases

(2015) Jingyi Sheng et al.   GROWTH FACTORS

Anticancer activity of halofuginone in a preclinical model of osteosarcoma: inhibition of tumor growth and lung metastases

(2015) Audrey Lamora et al.   Oncotarget

Overexpression of Smad7 Blocks Primary Tumor Growth and Lung Metastasis Development in Osteosarcoma

(2014) A. Lamora et al.   CLINICAL CANCER RESEARCH

Signaling pathway cooperation in TGF-β-induced epithelial–mesenchymal transition

(2014) Rik Derynck et al.   CURRENT OPINION IN CELL BIOLOGY

Transforming Growth Factor-Beta Polymorphisms and Serum Level in the Development of Osteosarcoma

(2014) Shaogang Xu et al.   DNA AND CELL BIOLOGY

TGF- : Duality of Function Between Tumor Prevention and Carcinogenesis

(2014) D. R. Principe et al.   JNCI-Journal of the National Cancer Institute

Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma

(2014) John C. Morris et al.   PLoS One

Interferon consensus sequence-binding protein (ICSBP) promotes epithelial-to-mesenchymal transition (EMT)-like phenomena, cell-motility and invasion via TGF-β signaling in U2OS cells

(2014) J Y Sung et al.   Cell Death & Disease

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

(2014) Xiang Chen et al.   Cell Reports

Targeting TGF-β signaling in cancer

(2013) Lior H Katz et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The up-regulation of cysteine-rich protein 61 induced by transforming growth factor beta enhances osteosarcoma cell migration

(2013) Jun Chen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

TGF-β signalling and its role in cancer progression and metastasis

(2012) Yvette Drabsch et al.   CANCER AND METASTASIS REVIEWS

Anti-TGF-β Antibody Combined with Dendritic Cells Produce Antitumor Effects in Osteosarcoma

(2012) Masanori Kawano et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

TGF-β signaling and epithelial–mesenchymal transition in cancer progression

(2012) Yoko Katsuno et al.   CURRENT OPINION IN ONCOLOGY

Complexities of TGF-β Targeted Cancer Therapy

(2012) Erin C. Connolly et al.   International Journal of Biological Sciences

What’s New in Primary Bone Tumors

(2012) Joseph H. Schwab et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The TGFbeta Superfamily Signaling Pathway

(2012) Alexander Weiss et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Podoplanin Is Regulated by AP-1 and Promotes Platelet Aggregation and Cell Migration in Osteosarcoma

(2011) Akiko Kunita et al.   AMERICAN JOURNAL OF PATHOLOGY

RLIM interacts with Smurf2 and promotes TGF-β induced U2OS cell migration

(2011) Yongsheng Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma

(2011) Masanobu Tsubaki et al.   CYTOKINE

Rare cancers are not so rare: The rare cancer burden in Europe

(2011) Gemma Gatta et al.   EUROPEAN JOURNAL OF CANCER

Prodomains regulate the synthesis, extracellular localisation and activity of TGF-β superfamily ligands

(2011) Craig A. Harrison et al.   GROWTH FACTORS

Incidence and survival of malignant bone sarcomas in England 1979-2007

(2011) Jeremy Whelan et al.   INTERNATIONAL JOURNAL OF CANCER

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

TGF-β-related mechanisms of bone destruction in multiple myeloma

(2010) Toshio Matsumoto et al.   BONE

TGF-β in cancer and bone: Implications for treatment of bone metastases

(2010) Patricia Juárez et al.   BONE

TGF- -RI Kinase Inhibitor SD-208 Reduces the Development and Progression of Melanoma Bone Metastases

(2010) K. S. Mohammad et al.   CANCER RESEARCH

Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth

(2010) Serif Senturk et al.   HEPATOLOGY

Targeted therapy for high-grade glioma with the TGF- 2 inhibitor trabedersen: results of a randomized and controlled phase IIb study

(2010) U. Bogdahn et al.   NEURO-ONCOLOGY

The regulation of TGF  signal transduction

(2009) A. Moustakas et al.   DEVELOPMENT

Primary Osteogenic Sarcoma with Pulmonary Metastasis: Clinical Results and Prognostic Factors in 91 Patients

(2009) P. K. Wu et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Pharmacologic Inhibition of the TGF-β Type I Receptor Kinase Has Anabolic and Anti-Catabolic Effects on Bone

(2009) Khalid S. Mohammad et al.   PLoS One

Roles of TGFβ in metastasis

(2008) David Padua et al.   CELL RESEARCH