Drug resistance in eukaryotic microorganisms

New Vaccines for the World's Poorest People

(2016) Peter J. Hotez et al.   Annual Review of Medicine

Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study

(2016) Chanaki Amaratunga et al.   LANCET INFECTIOUS DISEASES

Inhibiting fungal multidrug resistance by disrupting an activator–Mediator interaction

(2016) Joy L. Nishikawa et al.   NATURE

Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes

(2016) C. D. Goodman et al.   SCIENCE

Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2

(2016) Jie Song et al.   PLoS Pathogens

The molecular basis of antifolate resistance inPlasmodium falciparum: looking beyond point mutations

(2015) Adina Heinberg et al.   Annals of the New York Academy of Sciences

A multi-center, open-label trial to compare the efficacy and pharmacokinetics of Artemether-Lumefantrine in children with severe acute malnutrition versus children without severe acute malnutrition: study protocol for the MAL-NUT study

(2015) Lise Denoeud-Ndam et al.   BMC INFECTIOUS DISEASES

Azole Resistance inAspergillus fumigatus: Can We Retain the Clinical Use of Mold-Active Antifungal Azoles?

(2015) Paul E. Verweij et al.   CLINICAL INFECTIOUS DISEASES

Ensuring transmission through dynamic host environments: host–pathogen interactions in Plasmodium sexual development

(2015) Kathleen W Dantzler et al.   CURRENT OPINION IN MICROBIOLOGY

Nitroheterocyclic drug resistance mechanisms inTrypanosoma brucei

(2015) Susan Wyllie et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The ever-evolving landscape of candidaemia in patients with acute leukaemia: non-susceptibility to caspofungin and multidrug resistance are associated with increased mortality

(2015) Emily Wang et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole

(2015) Bianca Zingales et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Generation of an aquaglyceroporin AQP1 null mutant in Leishmania major

(2015) Marie Plourde et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Multi-triazole-resistantAspergillus fumigatusinfections in Australia

(2015) Sarah E. Kidd et al.   MYCOSES

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

(2015) Alassane Mbengue et al.   NATURE

Invasive Candidiasis

(2015) Bart Jan Kullberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy

(2015) Carlos A. Morillo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antimicrobial resistance in humans, livestock and the wider environment

(2015) M. Woolhouse et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation inpfcrt

(2015) Stéphane Pelleau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How to bolster the antifungal pipeline

(2015) D. W. Denning et al.   SCIENCE

The Social Life of African Trypanosomes

(2015) Simon Imhof et al.   TRENDS IN PARASITOLOGY

Commit and Transmit: Molecular Players in Plasmodium Sexual Development and Zygote Differentiation

(2015) David S. Guttery et al.   TRENDS IN PARASITOLOGY

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities

(2015) Serena Pulcini et al.   Scientific Reports

Arsenic Exposure and Outcomes of Antimonial Treatment in Visceral Leishmaniasis Patients in Bihar, India: A Retrospective Cohort Study

(2015) Meghan R. Perry et al.   PLoS Neglected Tropical Diseases

Coping with Stress and the Emergence of Multidrug Resistance in Fungi

(2015) Erika Shor et al.   PLoS Pathogens

Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

(2015) Fabrice E. Graf et al.   International Journal for Parasitology-Drugs and Drug Resistance

Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine

(2014) Meera Venkatesan et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Multi-analytical platform metabolomic approach to study miltefosine mechanism of action and resistance in Leishmania

(2014) Gisele A. B. Canuto et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Drug Target Identification Using a Trypanosome Overexpression Library

(2014) Daniela Begolo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Trypanosoma bruceieflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids

(2014) Christoph Mathieu et al.   BIOCHEMICAL JOURNAL

An update on pharmacotherapy for leishmaniasis

(2014) Shyam Sundar et al.   EXPERT OPINION ON PHARMACOTHERAPY

Recent Clinical Trials for the Etiological Treatment of Chronic Chagas Disease: Advances, Challenges and Perspectives

(2014) Julio A. Urbina   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Genetics of chloroquine-resistant malaria: a haplotypic view

(2014) Gauri Awasthi et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Policy: An intergovernmental panel on antimicrobial resistance

(2014) Mark Woolhouse et al.   NATURE

Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system

(2014) Mehdi Ghorbal et al.   NATURE BIOTECHNOLOGY

Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes

(2014) Lucy Glover et al.   Nature Protocols

Randomized Trial of Posaconazole and Benznidazole for Chronic Chagas' Disease

(2014) Israel Molina et al.   NEW ENGLAND JOURNAL OF MEDICINE

The journey towards elimination of gambiense human African trypanosomiasis: not far, nor easy

(2014) J. R. FRANCO et al.   PARASITOLOGY

Comparative transcript expression analysis of miltefosine-sensitive and miltefosine-resistant Leishmania donovani

(2014) Arpita Kulshrestha et al.   PARASITOLOGY RESEARCH

The role of vector control in stopping the transmission of malaria: threats and opportunities

(2014) J. Hemingway   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

(2014) S. Mok et al.   SCIENCE

Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects

(2014) Stephen Patterson et al.   TRENDS IN PARASITOLOGY

Parasexuality and mosaic aneuploidy in Leishmania: alternative genetics

(2014) Yvon Sterkers et al.   TRENDS IN PARASITOLOGY

Mechanisms of Antifungal Drug Resistance

(2014) Leah E. Cowen et al.   Cold Spring Harbor Perspectives in Medicine

Melarsoprol Sensitivity Profile of Trypanosoma brucei gambiense Isolates from Cured and Relapsed Sleeping Sickness Patients from the Democratic Republic of the Congo

(2014) Patient Pyana Pati et al.   PLoS Neglected Tropical Diseases

Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

(2014) Andrea Trochine et al.   PLoS Neglected Tropical Diseases

Efflux pump proteins in antifungal resistance

(2014) Rajendra Prasad et al.   Frontiers in Pharmacology

Current status and future challenges for controlling malaria with the sterile insect technique: Technical and social perspectives

(2013) Clelia F. Oliva et al.   ACTA TROPICA

New Insight into Amphotericin B Resistance in Aspergillus terreus

(2013) Gerhard Blum et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A New ABC Half-Transporter in Leishmania major Is Involved in Resistance to Antimony

(2013) J. I. Manzano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles

(2013) Neta Regev-Rudzki et al.   CELL

Microbial Persistence and the Road to Drug Resistance

(2013) Nadia R. Cohen et al.   Cell Host & Microbe

Malaria-Infected Erythrocyte-Derived Microvesicles Mediate Cellular Communication within the Parasite Population and with the Host Immune System

(2013) Pierre-Yves Mantel et al.   Cell Host & Microbe

A Multistep Voriconazole-Related Phototoxic Pathway May Lead to Skin Carcinoma: Results From a French Nationwide Study

(2013) O. Epaulard et al.   CLINICAL INFECTIOUS DISEASES

Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations

(2013) Barbara D. Alexander et al.   CLINICAL INFECTIOUS DISEASES

Increasing Failure of Miltefosine in the Treatment of Kala-azar in Nepal and the Potential Role of Parasite Drug Resistance, Reinfection, or Noncompliance

(2013) Suman Rijal et al.   CLINICAL INFECTIOUS DISEASES

Management and diagnostic guidelines for fungal diseases in infectious diseases and clinical microbiology: critical appraisal

(2013) S. Leroux et al.   CLINICAL MICROBIOLOGY AND INFECTION

Azole resistance in Aspergillus fumigatus

(2013) Edith Vermeulen et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

(2013) J. C. Munday et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

(2013) Binny M. Mony et al.   NATURE

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

(2013) Olivo Miotto et al.   NATURE GENETICS

Development of vaccines for Candida albicans: fighting a skilled transformer

(2013) Antonio Cassone   NATURE REVIEWS MICROBIOLOGY

Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis

(2013) M. R. Perry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leishmaniasis: clinical syndromes and treatment

(2013) B. S. McGwire et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol

(2013) Fabrice E. Graf et al.   PLoS Neglected Tropical Diseases

Emergence of Azole-Resistant Aspergillus fumigatus Strains due to Agricultural Azole Use Creates an Increasing Threat to Human Health

(2013) Anuradha Chowdhary et al.   PLoS Pathogens

Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism

(2013) Isabel M. Vincent et al.   International Journal for Parasitology-Drugs and Drug Resistance

Fks1 and Fks2 Are Functionally Redundant but Differentially Regulated in Candida glabrata: Implications for Echinocandin Resistance

(2012) Santosh K. Katiyar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria

(2012) Katarzyna KINGA Modrzynska et al.   BMC GENOMICS

Efficacy of Miltefosine in the Treatment of Visceral Leishmaniasis in India After a Decade of Use

(2012) S. Sundar et al.   CLINICAL INFECTIOUS DISEASES

Gain-of-Function Mutations in UPC2 Are a Frequent Cause of ERG11 Upregulation in Azole-Resistant Clinical Isolates of Candida albicans

(2012) Stephanie A. Flowers et al.   EUKARYOTIC CELL

Transcriptional variation in the malaria parasite Plasmodium falciparum

(2012) N. Rovira-Graells et al.   GENOME RESEARCH

Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

(2012) T. P. C. Dorlo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Progress in Antifungal Susceptibility Testing of Candida spp. by Use of Clinical and Laboratory Standards Institute Broth Microdilution Methods, 2010 to 2012

(2012) M. A. Pfaller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Benznidazole-Resistance in Trypanosoma cruzi Is a Readily Acquired Trait That Can Arise Independently in a Single Population

(2012) Ana Maria Mejia et al.   JOURNAL OF INFECTIOUS DISEASES

Improving Sterile Insect Technique (SIT) for tsetse flies through research on their symbionts and pathogens

(2012) Adly M.M. Abd-Alla et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

Poor-quality antimalarial drugs in southeast Asia and sub-Saharan Africa

(2012) Gaurvika ML Nayyar et al.   LANCET INFECTIOUS DISEASES

Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study

(2012) Chanaki Amaratunga et al.   LANCET INFECTIOUS DISEASES

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

(2012) Magnus Manske et al.   NATURE

Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation

(2012) P. K. Fyfe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amphotericin primarily kills yeast by simply binding ergosterol

(2012) K. C. Gray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia

(2012) S. Takala-Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

(2012) N. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Major Genome Region Underlying Artemisinin Resistance in Malaria

(2012) I. H. Cheeseman et al.   SCIENCE

PfCRT and its role in antimalarial drug resistance

(2012) Andrea Ecker et al.   TRENDS IN PARASITOLOGY

Multiple Mutations in Heterogeneous Miltefosine-Resistant Leishmania major Population as Determined by Whole Genome Sequencing

(2012) Adriano C. Coelho et al.   PLoS Neglected Tropical Diseases

Molecular Mechanisms of Drug Resistance in Natural Leishmania Populations Vary with Genetic Background

(2012) Saskia Decuypere et al.   PLoS Neglected Tropical Diseases

Aneuploidy and Drug Resistance in Pathogenic Fungi

(2012) Kyung J. Kwon-Chung et al.   PLoS Pathogens

Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation

(2011) Belinda S. Hall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Azole resistance inAspergillus fumigatus: a new challenge in the management of invasive aspergillosis?

(2011) Eveline Snelders et al.   Future Microbiology

Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania

(2011) M. B. Rogers et al.   GENOME RESEARCH

Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

(2011) Belinda S. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detailed comparison of Candida albicans and Candida glabrata biofilms under different conditions and their susceptibility to caspofungin and anidulafungin

(2011) S. Kucharikova et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Differential expression of proteins in antimony-susceptible and -resistant isolates of Leishmania donovani

(2011) Neha Biyani et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets

(2011) J. Yuan et al.   SCIENCE

Visceral Leishmaniasis and Arsenic: An Ancient Poison Contributing to Antimonial Treatment Failure in the Indian Subcontinent?

(2011) Meghan R. Perry et al.   PLoS Neglected Tropical Diseases

Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

(2010) A. Y. Sokolova et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transporters as mediators of drug resistance in Plasmodium falciparum

(2010) Cecilia P. Sanchez et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Assessing aquaglyceroporin gene status and expression profile in antimony-susceptible and -resistant clinical isolates of Leishmania donovani from India

(2010) S. Mandal et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates

(2010) Susan Wyllie et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum

(2010) Stephanie G. Valderramos et al.   PLoS Pathogens

A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes

(2010) Isabel M. Vincent et al.   PLoS Pathogens

Patients with Long-Term Oral Carriage Harbor High-Persister Mutants of Candida albicans

(2009) M. D. LaFleur et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efflux-Mediated Antifungal Drug Resistance

(2009) R. D. Cannon et al.   CLINICAL MICROBIOLOGY REVIEWS

Characterisation of breakthrough invasive mycoses in echinocandin recipients: an evidence-based review

(2009) Hsin-Yun Sun et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

In Vivo Selection ofPlasmodium falciparumParasites Carrying the Chloroquine-SusceptiblepfcrtK76 Allele after Treatment with Artemether-Lumefantrine in Africa

(2009) Christin Sisowath et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular Basis of Antimony Treatment in Leishmaniasis†

(2009) Paola Baiocco et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

(2009) Gerardo Priotto et al.   LANCET

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genotypic Status of the TbAT1/P2 Adenosine Transporter of Trypanosoma brucei gambiense Isolates from Northwestern Uganda following Melarsoprol Withdrawal

(2009) Anne J. N. Kazibwe et al.   PLoS Neglected Tropical Diseases

Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin

(2009) Sheena D. Singh et al.   PLoS Pathogens

Roles of Trypanothione S-Transferase and Tryparedoxin Peroxidase in Resistance to Antimonials

(2008) S. Wyllie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of an ABCG-Like Transporter from the Protozoan Parasite Leishmania with a Role in Drug Resistance and Transbilayer Lipid Movement

(2008) E. Castanys-Munoz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Proteomic Analysis of Trypanosoma cruzi Resistance to Benznidazole

(2008) Hélida M. Andrade et al.   JOURNAL OF PROTEOME RESEARCH

An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1

(2008) Anna Selmecki et al.   MOLECULAR MICROBIOLOGY

The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype

(2008) Leah E. Cowen   NATURE REVIEWS MICROBIOLOGY

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atovaquone-Proguanil Resistance in Imported Falciparum Malaria in a Young Child

(2008) Gregory W. Rose et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

(2008) Shane R. Wilkinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevalence and Detection of Counterfeit Pharmaceuticals:  A Mini Review

(2007) Facundo M. Fernandez et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH