Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol

Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

(2013) Nicola Baker et al.   TRENDS IN PARASITOLOGY

Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake

(2013) Jane C. Munday et al.   International Journal for Parasitology-Drugs and Drug Resistance

Antiparasitic agents: new drugs on the horizon

(2012) Pascal Mäser et al.   CURRENT OPINION IN PHARMACOLOGY

Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

(2012) N. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antitrypanosomal Activity of Fexinidazole, a New Oral Nitroimidazole Drug Candidate for Treatment of Sleeping Sickness

(2011) Marcel Kaiser et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Functional Characterization of Three Aquaglyceroporins from Trypanosoma brucei in Osmoregulation and Glycerol Transport

(2011) Björn Bassarak et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Diamidine Diminazene Aceturate Is a Substrate for the High-Affinity Pentamidine Transporter: Implications for the Development of High Resistance Levels in Trypanosomes

(2011) I. A. Teka et al.   MOLECULAR PHARMACOLOGY

MIPModDB: a central resource for the superfamily of major intrinsic proteins

(2011) A. B. Gupta et al.   NUCLEIC ACIDS RESEARCH

Isolation of Trypanosoma brucei gambiense from Cured and Relapsed Sleeping Sickness Patients and Adaptation to Laboratory Mice

(2011) Patient Pati Pyana et al.   PLoS Neglected Tropical Diseases

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

(2011) Robert T. Jacobs et al.   PLoS Neglected Tropical Diseases

Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis

(2010) B. Nare et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6

(2010) Nicola Baker et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters

(2010) Gabriela Schumann Burkard et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness

(2010) Els Torreele et al.   PLoS Neglected Tropical Diseases

The Genome Sequence of Trypanosoma brucei gambiense, Causative Agent of Chronic Human African Trypanosomiasis

(2010) Andrew P. Jackson et al.   PLoS Neglected Tropical Diseases

A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes

(2010) Isabel M. Vincent et al.   PLoS Pathogens

Multiple Genetic Mechanisms Lead to Loss of Functional TbAT1 Expression in Drug-Resistant Trypanosomes

(2009) Mhairi L. Stewart et al.   EUKARYOTIC CELL

Human African trypanosomiasis

(2009) Reto Brun et al.   LANCET

Genotypic Status of the TbAT1/P2 Adenosine Transporter of Trypanosoma brucei gambiense Isolates from Northwestern Uganda following Melarsoprol Withdrawal

(2009) Anne J. N. Kazibwe et al.   PLoS Neglected Tropical Diseases

The continuing problem of human African trypanosomiasis (sleeping sickness)

(2008) Peter G. E. Kennedy   ANNALS OF NEUROLOGY

Ever-increasing complexities of diamidine and arsenical crossresistance in African trypanosomes

(2008) Harry P. de Koning   TRENDS IN PARASITOLOGY