Multi-analytical platform metabolomic approach to study miltefosine mechanism of action and resistance in Leishmania

Intracellular growth and pathogenesis ofLeishmaniaparasites

(2015) Thomas Naderer et al.   Essays in Biochemistry

Increasing Failure of Miltefosine in the Treatment of Kala-azar in Nepal and the Potential Role of Parasite Drug Resistance, Reinfection, or Noncompliance

(2013) Suman Rijal et al.   CLINICAL INFECTIOUS DISEASES

Miltefosine resistance in Leishmania donovani involves suppression of oxidative stress-induced programmed cell death

(2013) Jyotsna Mishra et al.   EXPERIMENTAL PARASITOLOGY

Miltefosine-unresponsiveLeishmania donovanihas a greater ability than miltefosine-responsiveL. donovanito resist reactive oxygen species

(2013) Mousumi Das et al.   FEBS Journal

Current metabolomics: Technological advances

(2013) Sastia P. Putri et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Case study for a vaccine against leishmaniasis

(2013) Jorge Alvar et al.   VACCINE

NMR and pattern recognition methods in metabolomics: From data acquisition to biomarker discovery: A review

(2012) Agnieszka Smolinska et al.   ANALYTICA CHIMICA ACTA

Quantitative NMR for bioanalysis and metabolomics

(2012) Gregory A. Barding et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A versatile proline/alanine transporter in the unicellular pathogenLeishmania donovaniregulates amino acid homoeostasis and osmotic stress responses

(2012) Ehud Inbar et al.   BIOCHEMICAL JOURNAL

CE-ESI-MS metabolic fingerprinting of Leishmania resistance to antimony treatment

(2012) Gisele A. B. Canuto et al.   ELECTROPHORESIS

Leishmaniasis: an update of current pharmacotherapy

(2012) Shyam Sundar et al.   EXPERT OPINION ON PHARMACOTHERAPY

Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

(2012) T. P. C. Dorlo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Metabolic Characterization of Leishmania major Infection in Activated and Nonactivated Macrophages.

(2012) Sabrina D. Lamour et al.   JOURNAL OF PROTEOME RESEARCH

Leishmania donovani mitochondrial iron superoxide dismutase A is released into the cytosol during miltefosine induced programmed cell death

(2012) Fitsum Getachew et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Cell death in parasitic protozoa: regulated or incidental?

(2012) William R. Proto et al.   NATURE REVIEWS MICROBIOLOGY

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation

(2012) P. K. Fyfe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LC–MS metabolomics of polar compounds

(2012) David Rojo et al.   Bioanalysis

Multiple Mutations in Heterogeneous Miltefosine-Resistant Leishmania major Population as Determined by Whole Genome Sequencing

(2012) Adriano C. Coelho et al.   PLoS Neglected Tropical Diseases

Leishmania donovani Develops Resistance to Drug Combinations

(2012) Raquel García-Hernández et al.   PLoS Neglected Tropical Diseases

Drug Susceptibility in Leishmania Isolates Following Miltefosine Treatment in Cases of Visceral Leishmaniasis and Post Kala-Azar Dermal Leishmaniasis

(2012) Vasundhra Bhandari et al.   PLoS Neglected Tropical Diseases

Identification of phospholipid species affected by miltefosine action in Leishmania donovani cultures using LC-ELSD, LC-ESI/MS, and multivariate data analysis

(2011) L. Imbert et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Toward Global Metabolomics Analysis with Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry: Improved Metabolite Identification by Retention Time Prediction

(2011) Darren J. Creek et al.   ANALYTICAL CHEMISTRY

The 8-Aminoquinoline Analogue Sitamaquine Causes Oxidative Stress in Leishmania donovani Promastigotes by Targeting Succinate Dehydrogenase

(2011) Luis Carvalho et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Leishmaniasis chemotherapy—challenges and opportunities

(2011) S.L. Croft et al.   CLINICAL MICROBIOLOGY AND INFECTION

Lights and shadows on gene organization and regulation of gene expression in Leishmania

(2011) Jose et al.   Frontiers in Bioscience-Landmark

Vaccine candidates for leishmaniasis: A review

(2011) Rajeev Nagill et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isotopomer Profiling ofLeishmania mexicanaPromastigotes Reveals Important Roles for Succinate Fermentation and Aspartate Uptake in Tricarboxylic Acid Cycle (TCA) Anaplerosis, Glutamate Synthesis, and Growth

(2011) Eleanor C. Saunders et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capillary electrophoresis as a metabolomics tool for non-targeted fingerprinting of biological samples

(2011) C. Barbas et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Contribution of proteomics of Leishmania spp. to the understanding of differentiation, drug resistance mechanisms, vaccine and drug development

(2011) Daniel Paape et al.   Journal of Proteomics

Metabolomic analysis of trypanosomatid protozoa

(2011) Darren J. Creek et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Miltefosine Induces Apoptosis-Like Cell Death in Yeast via Cox9p in Cytochrome c Oxidase

(2011) X. Zuo et al.   MOLECULAR PHARMACOLOGY

CYP5122A1, a Novel Cytochrome P450 Is Essential for Survival of Leishmania donovani

(2011) Smriti Verma et al.   PLoS One

Axenic Leishmania amazonensis Promastigotes Sense both the External and Internal Arginine Pool Distinctly Regulating the Two Transporter-Coding Genes

(2011) Emerson A. Castilho-Martins et al.   PLoS One

Paromomycin Affects Translation and Vesicle-Mediated Trafficking as Revealed by Proteomics of Paromomycin –Susceptible –Resistant Leishmania donovani

(2011) Bhavna Chawla et al.   PLoS One

Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania

(2011) W Moreira et al.   Cell Death & Disease

Lysine transporters in human trypanosomatid pathogens

(2010) Ehud Inbar et al.   AMINO ACIDS

Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis

(2010) Ruben t’Kindt et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Metabolic Pathways Required for the Intracellular Survival of Leishmania

(2010) Malcolm J. McConville et al.   Annual Review of Microbiology

Combination therapy for visceral leishmaniasis

(2010) Johan van Griensven et al.   LANCET INFECTIOUS DISEASES

Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids

(2010) José M Jiménez-López et al.   Lipids in Health and Disease

Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives

(2010) Maud M. Koek et al.   Metabolomics

Highly specific methyl-end fatty-acid desaturases of trypanosomatids

(2010) Andrés Alloatti et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The potential of metabolomics for Leishmania research in the post-genomics era

(2010) RICHARD A. SCHELTEMA et al.   PARASITOLOGY

Central carbon metabolism of Leishmania parasites

(2010) ELEANOR C. SAUNDERS et al.   PARASITOLOGY

Disruption of the Lipid-Transporting LdMT-LdRos3 Complex in Leishmania donovani Affects Membrane Lipid Asymmetry but Not Host Cell Invasion

(2010) Adrien Weingärtner et al.   PLoS One

Metabolomics to Unveil and Understand Phenotypic Diversity between Pathogen Populations

(2010) Ruben t'Kindt et al.   PLoS Neglected Tropical Diseases

Low Plasma Membrane Expression of the Miltefosine Transport Complex Renders Leishmania braziliensis Refractory to the Drug

(2009) M. P. Sanchez-Canete et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

LeishCyc: a biochemical pathways database for Leishmania major

(2009) Maria A Doyle et al.   BMC Systems Biology

Cellular Transport and Lipid Interactions of Miltefosine

(2009) Gillian Barratt et al.   CURRENT DRUG METABOLISM

Arginine Homeostasis and Transport in the Human PathogenLeishmania donovani

(2009) Ilona Darlyuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active Transport of Glutamate inLeishmania(Leishmania)amazonensis

(2009) LISVANE S. PAES et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Leishmania major lacking arginase (ARG) are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice

(2009) Rosa M. Reguera et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

In Vitro Susceptibility of Field Isolates of Leishmania donovani to Miltefosine and Amphotericin B: Correlation with Sodium Antimony Gluconate Susceptibility and Implications for Treatment in Areas of Endemicity

(2008) D. Kumar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of an ABCG-Like Transporter from the Protozoan Parasite Leishmania with a Role in Drug Resistance and Transbilayer Lipid Movement

(2008) E. Castanys-Munoz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Advances in separation science applied to metabonomics

(2008) Li Xiayan et al.   ELECTROPHORESIS

Comparison between charged aerosol detection and light scattering detection for the analysis of Leishmania membrane phospholipids

(2008) R. Godoy Ramos et al.   JOURNAL OF CHROMATOGRAPHY A

Retooling Leishmania metabolism: from sand fly gut to human macrophage

(2007) Doron Rosenzweig et al.   FASEB JOURNAL