Immune-modulating properties of ionizing radiation: rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitors

Radiotherapy Complements Immune Checkpoint Blockade

(2015) Shin Foong Ngiow et al.   CANCER CELL

Immune checkpoint targeting as anti-cancer immunotherapy: promises, questions, challenges and the need for predictive biomarkers at ASCO 2015

(2015) Hardev Pandha et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases

(2015) Benjamin Frey et al.   CANCER LETTERS

Radio-immunotherapy: the focused beam expands

(2015) Benjamin Frey et al.   LANCET ONCOLOGY

Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial

(2015) Encouse B Golden et al.   LANCET ONCOLOGY

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

143 The Combination of anti-TIM-3 and anti-PD-1 Checkpoint Inhibitors With Focused Radiation Resulted in a Synergistic Antitumor Immune Response in a Preclinical Glioma Model

(2015) Jennifer E. Kim et al.   NEUROSURGERY

Immune Checkpoint Inhibitors in Melanoma Provide the Cornerstones for Curative Therapies

(2015) Alexander M.M. Eggermont et al.   SEMINARS IN ONCOLOGY

Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner

(2015) N Werthmöller et al.   Cell Death & Disease

Heat Shock Protein 70 (Hsp70) Peptide Activated Natural Killer (NK) Cells for the Treatment of Patients with Non-Small Cell Lung Cancer (NSCLC) after Radiochemotherapy (RCTx) – From Preclinical Studies to a Clinical Phase II Trial

(2015) Hanno M. Specht et al.   Frontiers in Immunology

Update on checkpoint blockade therapy for lymphoma

(2015) Justin Kline et al.   Journal for ImmunoTherapy of Cancer

Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade

(2014) S. J. Dovedi et al.   CANCER RESEARCH

Low and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic function

(2014) R. Wunderlich et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

New insights into cancer immunoediting and its three component phases—elimination, equilibrium and escape

(2014) Deepak Mittal et al.   CURRENT OPINION IN IMMUNOLOGY

Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy

(2014) Udo S Gaipl et al.   Immunotherapy

Therapeutic uses of anti-PD-1 and anti-PD-L1 antibodies

(2014) G. K. Philips et al.   INTERNATIONAL IMMUNOLOGY

Combinations of Radiation Therapy and Immunotherapy for Melanoma: A Review of Clinical Outcomes

(2014) Christopher A. Barker et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Tumor Radiation Therapy Creates Therapeutic Vaccine Responses to the Colorectal Cancer Antigen GUCY2C

(2014) Matthew Witek et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

(2014) Liufu Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Norm- and hypo-fractionated radiotherapy is capable of activating human dendritic cells

(2014) Lorenz Kulzer et al.   Journal of Immunotoxicology

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Trial Watch

(2014) Erika Vacchelli et al.   OncoImmunology

Immune Modulation in Cancer with Antibodies

(2013) David B. Page et al.   Annual Review of Medicine

Low-Dose Irradiation Programs Macrophage Differentiation to an iNOS+/M1 Phenotype that Orchestrates Effective T Cell Immunotherapy

(2013) Felix Klug et al.   CANCER CELL

Antitumor immune responses induced by ionizing irradiation and further immune stimulation

(2013) Benjamin Frey et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas

(2013) Jing Zeng et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies

(2012) I. Verbrugge et al.   CANCER RESEARCH

Induction of Abscopal Anti-Tumor Immunity and Immunogenic Tumor Cell Death by Ionizing Irradiation - Implications for Cancer Therapies

(2012) B. Frey et al.   CURRENT MEDICINAL CHEMISTRY

The Tipping Point for Combination Therapy: Cancer Vaccines With Radiation, Chemotherapy, or Targeted Small Molecule Inhibitors

(2012) James W. Hodge et al.   SEMINARS IN ONCOLOGY

How Does Ionizing Irradiation Contribute to the Induction of Anti-Tumor Immunity?

(2012) Yvonne Rubner et al.   Frontiers in Oncology

The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon-Dependent Innate and Adaptive Immunity

(2011) B. C. Burnette et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Editorial—Non-DNA targeted effects

(2010) Sisko I. Salomaa et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody

(2009) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH