Global SUMOylation facilitates the multimodal neuroprotection afforded by quercetin against the deleterious effects of oxygen/glucose deprivation and the restoration of oxygen/glucose

Quercetin in Cancer Treatment, Alone or in Combination with Conventional Therapeutics?

(2015) Ana Brito et al.   CURRENT MEDICINAL CHEMISTRY

The involvement of p62–Keap1–Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity

(2015) Li-Li Ji et al.   FREE RADICAL BIOLOGY AND MEDICINE

A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation

(2015) Joshua D Bernstock et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hypophosphorylation of ribosomal protein S6 is a molecular mechanism underlying ischemic tolerance induced by either hibernation or preconditioning

(2015) Shin-ichi Miyake et al.   JOURNAL OF NEUROCHEMISTRY

Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection

(2015) Luis Leyton et al.   VIRUS RESEARCH

Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability

(2015) Kyuichi Kawabata et al.   Food & Function

Monitoring Keap1–Nrf2 interactions in single live cells

(2014) Liam Baird et al.   BIOTECHNOLOGY ADVANCES

Cbx4 Governs HIF-1α to Potentiate Angiogenesis of Hepatocellular Carcinoma by Its SUMO E3 Ligase Activity

(2014) Jie Li et al.   CANCER CELL

Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway

(2014) Bo-Lin Chen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Small Ubiquitin-Like Modifier 3–Modified Proteome Regulated by Brain Ischemia in Novel Small Ubiquitin-Like Modifier Transgenic Mice

(2014) Wei Yang et al.   STROKE

Global SUMOylation is a molecular mechanism underlying hypothermia-induced ischemic tolerance

(2014) Yang-ja Lee et al.   Frontiers in Cellular Neuroscience

SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia

(2013) Chun Guo et al.   EMBO JOURNAL

Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1

(2013) Hye-Kyung Na et al.   FREE RADICAL BIOLOGY AND MEDICINE

SUMO and Ischemic Tolerance

(2013) Yang-ja Lee et al.   NEUROMOLECULAR MEDICINE

Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases

(2013) Khushwant S. Bhullar et al.   Oxidative Medicine and Cellular Longevity

Potential Therapeutic Effects of Natural Heme Oxygenase-1 Inducers in Cardiovascular Diseases

(2012) Ignazio Barbagallo et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease

(2012) Lap Ho et al.   FASEB JOURNAL

Function and regulation of SUMO proteases

(2012) Christopher M. Hickey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global Protein Conjugation by Ubiquitin-Like-Modifiers during Ischemic Stress Is Regulated by MicroRNAs and Confers Robust Tolerance to Ischemia

(2012) Yang-ja Lee et al.   PLoS One

Enhanced SUMOylation and SENP-1 Protein Levels following Oxygen and Glucose Deprivation in Neurones

(2011) Helena Cimarosti et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SUMO2/3 Conjugation is an Endogenous Neuroprotective Mechanism

(2011) Anna Lena Datwyler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells

(2011) Karim Jiménez-Aliaga et al.   LIFE SCIENCES

Sumoylation of Hypoxia-Inducible Factor-1α Ameliorates Failure of Brain Stem Cardiovascular Regulation in Experimental Brain Death

(2011) Julie Y. H. Chan et al.   PLoS One

Elevated Global SUMOylation in Ubc9 Transgenic Mice Protects Their Brains against Focal Cerebral Ischemic Damage

(2011) Yang-ja Lee et al.   PLoS One

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

(2010) Ananta Paine et al.   BIOCHEMICAL PHARMACOLOGY

Heme oxygenase 1: Another possible target to explain the neuroprotective action of resveratrol, a multifaceted nutrient-based molecule

(2010) Stéphane Bastianetto et al.   EXPERIMENTAL NEUROLOGY

Resveratrol protects against experimental stroke: Putative neuroprotective role of heme oxygenase 1

(2010) Yoshihito Sakata et al.   EXPERIMENTAL NEUROLOGY

Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity

(2010) Jun Lu et al.   JOURNAL OF PATHOLOGY

Hypoxia-inducible Factor-1 Activation in Nonhypoxic Conditions: The Essential Role of Mitochondrial-derived Reactive Oxygen Species

(2010) David A. Patten et al.   MOLECULAR BIOLOGY OF THE CELL

PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia

(2010) X Kang et al.   ONCOGENE

Hypoxia Inactivates the VHL Tumor Suppressor through PIASy-Mediated SUMO Modification

(2010) Qiliang Cai et al.   PLoS One

Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress

(2009) Young-Joon Surh et al.   ARCHIVES OF PHARMACAL RESEARCH

SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation

(2009) Chao Huang et al.   EMBO JOURNAL

The multiple faces of quercetin in neuroprotection

(2009) Bernardino Ossola et al.   Expert Opinion On Drug Safety

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Deep Hypothermia Markedly Activates the Small Ubiquitin-Like Modifier Conjugation Pathway; Implications for the Fate of Cells Exposed to Transient Deep Hypothermic Cardiopulmonary Bypass

(2009) Wei Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SUMOylation participates in induction of ischemic tolerance

(2009) Yang ja Lee et al.   JOURNAL OF NEUROCHEMISTRY

Nrf2 signaling and cell survival

(2009) Suryakant K. Niture et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

SUMO under stress: Figure 1

(2008) Denis Tempé et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Raf and MEK Protein Kinases Are Direct Molecular Targets for the Chemopreventive Effect of Quercetin, a Major Flavonol in Red Wine

(2008) K. W. Lee et al.   CANCER RESEARCH

Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells

(2008) Seung-Nam Jung et al.   CARCINOGENESIS

Cerebral ischemiastroke and small ubiquitin-like modifier (SUMO) conjugation a new target for therapeutic intervention?

(2008) Wei Yang et al.   JOURNAL OF NEUROCHEMISTRY

Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation

(2007) Genevieve Bureau et al.   JOURNAL OF NEUROSCIENCE RESEARCH