Stimulation of PBMC and Monocyte-Derived Macrophages via Toll-Like Receptor Activates Innate Immune Pathways in HIV-Infected Patients on Virally Suppressive Combination Antiretroviral Therapy

Impaired gut junctional complexes feature late-treated individuals with suboptimal CD4+ T-cell recovery upon virologically suppressive combination antiretroviral therapy

(2016) Camilla Tincati et al.   AIDS

Systemic activation of the immune system in HIV infection: The role of the immune complexes (hypothesis)

(2016) Larisa B. Korolevskaya et al.   MEDICAL HYPOTHESES

Immune activation and cardiovascular disease in chronic HIV infection

(2016) Chris T. Longenecker et al.   Current Opinion in HIV and AIDS

Gut epithelial barrier and systemic inflammation during chronic HIV infection

(2015) Ma Somsouk et al.   AIDS

The role of inflammatory biomarkers in developing targeted cardiovascular therapies: lessons from the cardiovascular inflammation reduction trials

(2015) Gabriella Passacquale et al.   CARDIOVASCULAR RESEARCH

Gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection

(2015) S M Dillon et al.   Mucosal Immunology

Association between discordant immunological response to highly active anti-retroviral therapy, regulatory T cell percentage, immune cell activation and very low-level viraemia in HIV-infected patients

(2014) J. Saison et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Brief Report

(2014) Connie J. Kim et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication

(2014) Jan Kristoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Unraveling the relationship between microbial translocation and systemic immune activation in HIV infection

(2014) Liang Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Experimentally Induced Immune Activation in Natural Hosts of Simian Immunodeficiency Virus Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion

(2014) I. Pandrea et al.   JOURNAL OF IMMUNOLOGY

Impaired Restoration of Plasmacytoid Dendritic Cells in HIV-1-Infected Patients with Poor CD4 T Cell Reconstitution Is Associated with Decrease in Capacity to Produce IFN-  but Not Proinflammatory Cytokines

(2014) N. Sachdeva et al.   JOURNAL OF IMMUNOLOGY

Targeting of TLRs Inhibits CD4+Regulatory T Cell Function and Activates Lymphocytes in Human Peripheral Blood Mononuclear Cells

(2014) Kui Shin Voo et al.   JOURNAL OF IMMUNOLOGY

Rifaximin has a Marginal Impact on Microbial Translocation, T-cell Activation and Inflammation in HIV-Positive Immune Non-responders to Antiretroviral Therapy – ACTG A5286

(2014) Allan R. Tenorio et al.   JOURNAL OF INFECTIOUS DISEASES

Sevelamer Does Not Decrease Lipopolysaccharide or Soluble CD14 Levels But Decreases Soluble Tissue Factor, Low-Density Lipoprotein (LDL) Cholesterol, and Oxidized LDL Cholesterol Levels in Individuals With Untreated HIV Infection

(2014) Netanya G. Sandler et al.   JOURNAL OF INFECTIOUS DISEASES

Soluble Markers of Inflammation and Coagulation but Not T-Cell Activation Predict Non–AIDS-Defining Morbid Events During Suppressive Antiretroviral Treatment

(2014) Allan R. Tenorio et al.   JOURNAL OF INFECTIOUS DISEASES

Gut Epithelial Barrier Dysfunction and Innate Immune Activation Predict Mortality in Treated HIV Infection

(2014) Peter W. Hunt et al.   JOURNAL OF INFECTIOUS DISEASES

Intestinal Microbiota, Microbial Translocation, and Systemic Inflammation in Chronic HIV Infection

(2014) Duy M. Dinh et al.   JOURNAL OF INFECTIOUS DISEASES

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

Contribution of Intestinal Barrier Damage, Microbial Translocation and HIV-1 Infection Status to an Inflammaging Signature

(2014) Amanda K. Steele et al.   PLoS One

Progressive Proximal-to-Distal Reduction in Expression of the Tight Junction Complex in Colonic Epithelium of Virally-Suppressed HIV+ Individuals

(2014) Charlotte Y. Chung et al.   PLoS Pathogens

Inflammatory Co-morbidities in HIV+ Individuals: Learning Lessons from Healthy Ageing

(2014) Anna C. Hearps et al.   Current HIV/AIDS Reports

The impact of age on the prognostic capacity of CD8+ T-cell activation during suppressive antiretroviral therapy

(2013) Judith J. Lok et al.   AIDS

Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis

(2013) S. Kaptoge et al.   EUROPEAN HEART JOURNAL

Suppressed Th17 Levels Correlate with Elevated PIAS3, SHP2, and SOCS3 Expression in CD4 T Cells during Acute Simian Immunodeficiency Virus Infection

(2013) S. L. Bixler et al.   JOURNAL OF VIROLOGY

Increased Escherichia coli-Induced Interleukin-23 Production by CD16+ Monocytes Correlates with Systemic Immune Activation in Untreated HIV-1-Infected Individuals

(2013) J. A. Manuzak et al.   JOURNAL OF VIROLOGY

Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates

(2012) I. Pandrea et al.   BLOOD

Role ofIn VitroStimulation with Lipopolysaccharide on T-Cell Activation in HIV-Infected Antiretroviral-Treated Patients

(2012) Camilla Tincati et al.   Clinical & Developmental Immunology

HIV-1 gp120 Impairs the Induction of B Cell Responses by TLR9-Activated Plasmacytoid Dendritic Cells

(2012) N. P. Y. Chung et al.   JOURNAL OF IMMUNOLOGY

Human immunodeficiency virus and the gastrointestinal immune system: does highly active antiretroviral therapy restore gut immunity?

(2012) C T Costiniuk et al.   Mucosal Immunology

Inflammation, Coagulation and Cardiovascular Disease in HIV-Infected Individuals

(2012) Daniel A. Duprez et al.   PLoS One

The role of lipopolysaccharide as a marker of immune activation in HIV-1 infected patients: a systematic literature review

(2012) Matteo Vassallo et al.   Virology Journal

Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy

(2011) Peter W. Hunt et al.   AIDS

Microbial translocation predicts disease progression of HIV-infected antiretroviral-naive patients with high CD4+ cell count

(2011) Giulia Marchetti et al.   AIDS

Molecular Mechanisms and Pathological Consequences of Endotoxin Tolerance and Priming

(2011) Matthew Morris et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Evidence for Polymicrobic Flora Translocating in Peripheral Blood of HIV-Infected Patients with Poor Immune Response to Antiretroviral Therapy

(2011) Esther Merlini et al.   PLoS One

Exposure to HIV-1-encoded Toll-like receptor 8 ligands enhances monocyte response to microbial encoded Toll-like receptor 2/4 ligands

(2010) Marianne W Mureith et al.   AIDS

TLR Activation Pathways in HIV-1–Exposed Seronegative Individuals

(2010) Mara Biasin et al.   JOURNAL OF IMMUNOLOGY

Human Intestinal Lamina Propria CD1c+ Dendritic Cells Display an Activated Phenotype at Steady State and Produce IL-23 in Response to TLR7/8 Stimulation

(2010) S. M. Dillon et al.   JOURNAL OF IMMUNOLOGY

Persistent Microbial Translocation and Immune Activation in HIV‐1–Infected South Africans Receiving Combination Antiretroviral Therapy

(2010) Edana Cassol et al.   JOURNAL OF INFECTIOUS DISEASES

The Identification of Markers of Macrophage Differentiation in PMA-Stimulated THP-1 Cells and Monocyte-Derived Macrophages

(2010) Marc Daigneault et al.   PLoS One

Contrasting Roles for TLR Ligands in HIV-1 Pathogenesis

(2010) Beda Brichacek et al.   PLoS One

Biomarkers and HIV-associated cardiovascular disease

(2010) Jason V Baker et al.   Current Opinion in HIV and AIDS

Damaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections

(2010) Jacob D. Estes et al.   PLoS Pathogens

Genome-Wide mRNA Expression Correlates of Viral Control in CD4+ T-Cells from HIV-1-Infected Individuals

(2010) Margalida Rotger et al.   PLoS Pathogens

Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection

(2009) Richard T Lester et al.   AIDS

Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation

(2009) N. T. Funderburg et al.   BLOOD

Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys

(2009) Steven E. Bosinger et al.   JOURNAL OF CLINICAL INVESTIGATION

Serum Immune Activation Markers Are Persistently Increased in Patients with HIV Infection after 6 Years of Antiretroviral Therapy despite Suppression of Viral Replication and Reconstitution of CD4+T Cells

(2009) Martyn A. French et al.   JOURNAL OF INFECTIOUS DISEASES

Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral‐Treated HIV Infection

(2009) Wei Jiang et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 RNA Dysregulates the Natural TLR Response to Subclinical Endotoxemia in Kenyan Female Sex-Workers

(2009) Richard T. Lester et al.   PLoS One

HIV-1 Residual Viremia Correlates with Persistent T-Cell Activation in Poor Immunological Responders to Combination Antiretroviral Therapy

(2009) Maud Mavigner et al.   PLoS One

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy

(2008) Giulia Marchetti et al.   AIDS

Toll-Like Receptor Ligands Induce Human T Cell Activation and Death, a Model for HIV Pathogenesis

(2008) Nicholas Funderburg et al.   PLoS One

Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection

(2008) Lewis H Kuller et al.   PLOS MEDICINE

Chronic innate immune activation as a cause of HIV-1 immunopathogenesis

(2007) Adriano Boasso et al.   CLINICAL IMMUNOLOGY