The Antibiotic Drug Tigecycline: A Focus on its Promising Anticancer Properties

The mitochondrial pyruvate carrier in health and disease: To carry or not to carry?

(2016) Tom Bender et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells

(2016) Md Maksudul Alam et al.   BMC CANCER

Targeting PI3K Signaling in Cancer: A Cautionary Tale of Two AKTs

(2016) Jérôme Fortin et al.   CANCER CELL

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells

(2016) Eric R. Lechman et al.   CANCER CELL

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma

(2016) S. Agnihotri et al.   CANCER RESEARCH

SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth

(2016) Seong-Hoon Park et al.   CANCER RESEARCH

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained

(2016) Amit U. Joshi et al.   CELL CALCIUM

Differential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets

(2016) Erik Norberg et al.   CELL DEATH AND DIFFERENTIATION

Tigecycline targets nonsmall cell lung cancer through inhibition of mitochondrial function

(2016) Xuefeng Jia et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Tigecycline antimicrobial activity tested against clinical bacteria from Latin American medical centres: results from SENTRY Antimicrobial Surveillance Program (2011–2014)

(2016) Helio S. Sader et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii

(2016) Gauri G. Rao et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation

(2016) Robert A. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

The rise of mitochondria in medicine

(2016) Martin Picard et al.   MITOCHONDRION

Tigecycline Inhibits Glioma Growth by Regulating miRNA-199b-5p-HES1-AKT Pathway

(2016) R. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

(2016) Seyedmehdi Shojaee et al.   NATURE MEDICINE

A multi-layer omics approach to cancer

(2016) Denise Waldron   NATURE REVIEWS GENETICS

AKT signaling in ERBB2-amplified breast cancer

(2016) F. Javier Carmona et al.   PHARMACOLOGY & THERAPEUTICS

Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer

(2016) Amanda R. Oran et al.   Oncotarget

The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas

(2016) Aleco D’Andrea et al.   Oncotarget

Role of newer and re-emerging older agents in the treatment of infections caused by carbapenem-resistant Enterobacteriaceae

(2016) Joshua T. Thaden et al.   Virulence

A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia

(2016) Gregory A. Reed et al.   Cancer Medicine

Successful treatment of multiresistantAchromobacter xylosoxidansbacteremia in a child with acute myeloid leukemia

(2015) Deniz Tugcu et al.   ANNALS OF SAUDI MEDICINE

Therapeutic effects of antibiotic drug tigecycline against cervical squamous cell carcinoma by inhibiting Wnt/β-catenin signaling

(2015) Hui Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

(2015) Colin A. Flaveny et al.   CANCER CELL

HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer

(2015) Paloma Ordóñez-Morán et al.   CANCER CELL

HEATR1 Negatively Regulates Akt to Help Sensitize Pancreatic Cancer Cells to Chemotherapy

(2015) T. Liu et al.   CANCER RESEARCH

A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors

(2015) Quincy Siu-Chung Chu et al.   INVESTIGATIONAL NEW DRUGS

Potential burden of antibiotic resistance on surgery and cancer chemotherapy antibiotic prophylaxis in the USA: a literature review and modelling study

(2015) Aude Teillant et al.   LANCET INFECTIOUS DISEASES

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

(2015) Gabriele D’Uva et al.   NATURE CELL BIOLOGY

New roles for mitochondrial proteases in health, ageing and disease

(2015) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Discovery and functional characterization of a neomorphic PTEN mutation

(2015) Helio A. Costa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotic drug tigecycline reduces neuroblastoma cells proliferation by inhibiting Akt activation in vitro and in vivo

(2015) Xiaoxia Zhong et al.   TUMOR BIOLOGY

Antibiotic drug tigecycline inhibits melanoma progression and metastasis in a p21CIP1/Waf1-dependent manner

(2015) Huanrong Hu et al.   Oncotarget

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease

(2015) Rebecca Lamb et al.   Oncotarget

Antibiotic drug tigecycline inhibited cell proliferation and induced autophagy in gastric cancer cells

(2014) Chunling Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Complete Loss of PTEN Protein Expression Correlates with Shorter Time to Brain Metastasis and Survival in Stage IIIB/C Melanoma Patients with BRAFV600 Mutations

(2014) A. D. Bucheit et al.   CLINICAL CANCER RESEARCH

Antitumor Activity in RAS-Driven Tumors by Blocking AKT and MEK

(2014) A. W. Tolcher et al.   CLINICAL CANCER RESEARCH

Results of a Multicenter, Controlled, Randomized Clinical Trial Evaluating the Combination of Piperacillin/Tazobactam and Tigecycline in High-Risk Hematologic Patients With Cancer With Febrile Neutropenia

(2014) Giampaolo Bucaneve et al.   JOURNAL OF CLINICAL ONCOLOGY

ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1

(2014) Yihua Wang et al.   NATURE CELL BIOLOGY

A Novel Formulation of Tigecycline Has Enhanced Stability and Sustained Antibacterial and Antileukemic Activity

(2014) Yulia Jitkova et al.   PLoS One

Randomized Phase 2 Trial To Evaluate the Clinical Efficacy of Two High-Dosage Tigecycline Regimens versus Imipenem-Cilastatin for Treatment of Hospital-Acquired Pneumonia

(2013) Julio Ramirez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phase 3 study comparing tigecycline and ertapenem in patients with diabetic foot infections with and without osteomyelitis

(2013) Laszlo Lauf et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Targeted therapy against multi-resistant bacteria in leukemic and hematopoietic stem cell transplant recipients: guidelines of the 4th European Conference on Infections in Leukemia (ECIL-4, 2011)

(2013) D. Averbuch et al.   HAEMATOLOGICA

Tigecycline in febrile neutropenic patients with haematological malignancies: a retrospective case documentation in four university hospitals

(2013) K. S. Schwab et al.   INFECTION

Pancreatitis in tigecycline Phase 3 and 4 clinical studies

(2013) P. C. McGovern et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Metabolic Adaptation to Chronic Inhibition of Mitochondrial Protein Synthesis in Acute Myeloid Leukemia Cells

(2013) Bozhena Jhas et al.   PLoS One

Clinical and epidemiological features of Chryseobacterium indologenes infections: Analysis of 215 cases

(2012) Fu-Lun Chen et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Neutrophils Engraftment Delay During Tigecycline Treatment in 2 Bone Marrow–transplanted Patients

(2012) Natalia Maximova et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

(2012) Elise Ruark et al.   NATURE

Therapeutic potential of mitochondrial translation inhibition for treatment of acute myeloid leukemia

(2012) Aaron D Schimmer et al.   Expert Review of Hematology

Power Cut: Inhibiting Mitochondrial Translation to Target Leukemia

(2011) Marcus Järås et al.   CANCER CELL

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2011) Marko Škrtić et al.   CANCER CELL

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

(2011) Sarat Chandarlapaty et al.   CANCER CELL

Management of gram-positive bacterial infections in patients with cancer

(2011) Christos I. Kosmidis et al.   LEUKEMIA & LYMPHOMA

Myocardial AKT: The Omnipresent Nexus

(2011) Mark A. Sussman et al.   PHYSIOLOGICAL REVIEWS

Efficacy and safety of tigecycline monotherapy vs. imipenem/cilastatin in Chinese patients with complicated intra-abdominal infections: a randomized controlled trial

(2010) Zhangjing Chen et al.   BMC INFECTIOUS DISEASES

Empirical first-line treatment with tigecycline for febrile episodes following abdominal surgery in cancer patients

(2010) Giovanni Secondo et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Tigecycline treatment of multi-drug-resistant Corynebacterium jeikeium infection in a child with relapsing and refractory acute lymphoblastic leukemia

(2010) Ener Cagri Dinleyici et al.   PEDIATRIC BLOOD & CANCER

Safety and Efficacy of Intravenous Tigecycline in Subjects with Secondary Bacteremia: Pooled Results from 8 Phase III Clinical Trials

(2009) David Gardiner et al.   CLINICAL INFECTIOUS DISEASES

Tigecycline Use in Cancer Patients With Serious Infections

(2009) Roy F. Chemaly et al.   MEDICINE