Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis

Chondrocyte clusters adjacent to sites of cartilage degeneration have characteristics of progenitor cells

(2015) Yoshiaki Hoshiyama et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The Fibroblast Growth Factor signaling pathway

(2015) David M. Ornitz et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Deficiency in Perlecan/HSPG2 During Bone Development Enhances Osteogenesis and Decreases Quality of Adult Bone in Mice

(2014) Dylan A. Lowe et al.   CALCIFIED TISSUE INTERNATIONAL

The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling

(2014) Megan S. Lord et al.   MATRIX BIOLOGY

Depletion of Protease-Activated Receptor 2 but Not Protease-Activated Receptor 1 May Confer Protection Against Osteoarthritis in Mice Through Extracartilaginous Mechanisms

(2014) Miriam T. Jackson et al.   Arthritis & Rheumatology

Intraarticular Sprifermin (Recombinant Human Fibroblast Growth Factor 18) in Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial

(2014) L. Stefan Lohmander et al.   Arthritis & Rheumatology

Fibroblast Growth Factor 2 Drives Changes in Gene Expression Following Injury to Murine Cartilage In Vitro and In Vivo

(2013) Ka-Wing Chong et al.   ARTHRITIS AND RHEUMATISM

Synovial perlecan is required for osteophyte formation in knee osteoarthritis

(2013) Haruka Kaneko et al.   MATRIX BIOLOGY

Post-traumatic osteoarthritis: from mouse models to clinical trials

(2013) Christopher B. Little et al.   Nature Reviews Rheumatology

Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice

(2012) Tujun Weng et al.   ARTHRITIS AND RHEUMATISM

Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development

(2012) James Melrose et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Fibroblast growth factor-2 promotes catabolism via FGFR1-Ras-Raf-MEK1/2-ERK1/2 axis that coordinates with the PKCδ pathway in human articular chondrocytes

(2012) Dongyao Yan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Species-specific biological effects of FGF-2 in articular cartilage: Implication for distinct roles within the FGF receptor family

(2012) Xin Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Fibroblast growth factor control of cartilage homeostasis

(2012) M.B. Ellman et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A biomechanical role for perlecan in the pericellular matrix of articular cartilage

(2012) Rebecca E. Wilusz et al.   MATRIX BIOLOGY

Correlation between plasma and synovial fluid basic fibroblast growth factor with radiographic severity in primary knee osteoarthritis

(2011) Sittisak Honsawek et al.   INTERNATIONAL ORTHOPAEDICS

Fibroblast growth factor 2: good or bad guy in the joint?

(2011) Tonia L Vincent   ARTHRITIS RESEARCH & THERAPY

Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes

(2011) Dongyao Yan et al.   ARTHRITIS RESEARCH & THERAPY

Heparan Sulfate-Dependent Signaling of Fibroblast Growth Factor 18 by Chondrocyte-Derived Perlecan

(2010) Christine Y. Chuang et al.   BIOCHEMISTRY

Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells

(2010) Liping Xiao et al.   BONE

Comparative immunolocalisation of perlecan with collagen II and aggrecan in human foetal, newborn and adult ovine joint tissues demonstrates perlecan as an early developmental chondrogenic marker

(2010) Susan M. Smith et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis

(2009) Shi-Lu Chia et al.   ARTHRITIS AND RHEUMATISM

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

(2009) Frank Echtermeyer et al.   NATURE MEDICINE

Diverse Cell Signaling Events Modulated by Perlecan†

(2008) John M. Whitelock et al.   BIOCHEMISTRY

Perlecan, the “jack of all trades” proteoglycan of cartilaginous weight-bearing connective tissues

(2008) James Melrose et al.   BIOESSAYS

Reduced expression and function of bone morphogenetic protein-2 in bones of Fgf2 null mice

(2007) Takahiro Naganawa et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The major basement membrane components localize to the chondrocyte pericellular matrix — A cartilage basement membrane equivalent?

(2007) Alexander J. Kvist et al.   MATRIX BIOLOGY