Targeted Deletion of Kynurenine 3-Monooxygenase in Mice

Kynurenic acid protects against the homo-cysteine-induced impairment of endothelial cells

(2014) Katarzyna Wejksza. et al.   Pharmacological Reports

The Niacin Required for Optimum Growth Can Be Synthesized from L-Tryptophan in Growing Mice Lacking Tryptophan-2,3-Dioxygenase

(2013) Miki Terakata et al.   JOURNAL OF NUTRITION

Structural basis of kynurenine 3-monooxygenase inhibition

(2013) Marta Amaral et al.   NATURE

Targeting Kynurenine 3-Monooxygenase (KMO): Implications for Therapy in Huntingtons Disease

(2012) Mathuravani A. Thevandavakkam et al.   CNS & Neurological Disorders-Drug Targets

Indoleamine 2,3-dioxygenase as a Modifier of Pathogenic Inflammation in Cancer and other Inflammation-Associated Diseases

(2012) G. C. Prendergast et al.   CURRENT MEDICINAL CHEMISTRY

Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery

(2012) Flavio Moroni et al.   JOURNAL OF NEURAL TRANSMISSION

Establishment of True Niacin Deficiency in Quinolinic Acid Phosphoribosyltransferase Knockout Mice

(2012) Miki Terakata et al.   JOURNAL OF NUTRITION

Kynurenines in the CNS: recent advances and new questions

(2012) László Vécsei et al.   NATURE REVIEWS DRUG DISCOVERY

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

3-Hydroxykynurenine: An intriguing molecule exerting dual actions in the Central Nervous System

(2012) Ana Laura Colín-González et al.   NEUROTOXICOLOGY

An expanding range of targets for kynurenine metabolites of tryptophan

(2012) Trevor W. Stone et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Gas chromatography/tandem mass spectrometry detection of extracellular kynurenine and related metabolites in normal and lesioned rat brain

(2011) Francesca M. Notarangelo et al.   ANALYTICAL BIOCHEMISTRY

Downregulated Kynurenine 3-Monooxygenase Gene Expression and Enzyme Activity in Schizophrenia and Genetic Association With Schizophrenia Endophenotypes

(2011) Ikwunga Wonodi   ARCHIVES OF GENERAL PSYCHIATRY

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease

(2011) Susanna Campesan et al.   CURRENT BIOLOGY

Involvement of kynurenines in Huntington’s disease and stroke-induced brain damage

(2011) Trevor W. Stone et al.   JOURNAL OF NEURAL TRANSMISSION

Kynurenines and intestinal neurotransmission: the role of N-methyl-d-aspartate receptors

(2011) József Kaszaki et al.   JOURNAL OF NEURAL TRANSMISSION

The kynurenine system and immunoregulation

(2011) Yvette Mándi et al.   JOURNAL OF NEURAL TRANSMISSION

Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls

(2011) Maria Holtze   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress

(2011) R. Lugo-Huitrón et al.   NEUROTOXICOLOGY AND TERATOLOGY

The Indoleamine-2,3-Dioxygenase (IDO) Inhibitor 1-Methyl-D-tryptophan Upregulates IDO1 in Human Cancer Cells

(2011) Christiane A. Opitz et al.   PLoS One

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders

(2010) Gregory F. Oxenkrug   JOURNAL OF NEURAL TRANSMISSION

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

(2010) Yutang Wang et al.   NATURE MEDICINE

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

(2010) N. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired Kynurenine Pathway Metabolism in The Prefrontal Cortex of Individuals With Schizophrenia

(2010) K. V. Sathyasaikumar et al.   SCHIZOPHRENIA BULLETIN

Cortical Kynurenine Pathway Metabolism: A Novel Target for Cognitive Enhancement in Schizophrenia

(2010) I. Wonodi et al.   SCHIZOPHRENIA BULLETIN

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning

(2009) Amy C. Chess et al.   BEHAVIOURAL BRAIN RESEARCH

New promises for manipulation of kynurenine pathway in cancer and neurological diseases

(2009) Gabriele Costantino   EXPERT OPINION ON THERAPEUTIC TARGETS

On the relationship between the two branches of the kynurenine pathway in the rat brainin vivo

(2009) Laura Amori et al.   JOURNAL OF NEUROCHEMISTRY

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

(2008) Luigina Romani et al.   NATURE

Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder

(2008) Christine L. Miller et al.   NEUROCHEMISTRY INTERNATIONAL

Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: A role for IFN-γ?

(2008) Thomas J. Connor et al.   NEUROSCIENCE LETTERS

Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys

(2007) L GREGOIRE et al.   BEHAVIOURAL BRAIN RESEARCH