Glial contributions to visceral pain: implications for disease etiology and the female predominance of persistent pain

P2X7 receptor mediates activation of microglial cells in prostate of chemically irritated rats

(2017) Heng Zhang et al.   International Braz J Urol

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

(2016) Sarah Taves et al.   BRAIN BEHAVIOR AND IMMUNITY

Activity-triggered tetrapartite neuron–glial interactions following peripheral injury

(2016) Ke Ren et al.   CURRENT OPINION IN PHARMACOLOGY

Role of extracellular calcitonin gene-related peptide in spinal cord mechanisms of cancer-induced bone pain

(2016) Rikke R. Hansen et al.   PAIN

Targeting p38 Mitogen-activated Protein Kinase to Reduce the Impact of Neonatal Microglial Priming on Incision-induced Hyperalgesia in the Adult Rat

(2015) Fred Schwaller et al.   ANESTHESIOLOGY

Commentary on the influence of gender on the management of chronic pelvic pain

(2015) NC Curran   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Evidence for brain glial activation in chronic pain patients

(2015) Marco L. Loggia et al.   BRAIN

Toll-like Receptor 4 and comorbid pain in Interstitial Cystitis/Bladder Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain research network study

(2015) Andrew Schrepf et al.   BRAIN BEHAVIOR AND IMMUNITY

Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain

(2015) Susannah S. Lewis et al.   BRAIN BEHAVIOR AND IMMUNITY

Modality and sex differences in pain sensitivity during human endotoxemia

(2015) B. Karshikoff et al.   BRAIN BEHAVIOR AND IMMUNITY

A novel use for testosterone to treat central sensitization of chronic pain in fibromyalgia patients

(2015) Hillary D. White et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain — Interleukin-8 in fibromyalgia and interleukin-1 β in rheumatoid arthritis

(2015) Eva Kosek et al.   JOURNAL OF NEUROIMMUNOLOGY

Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta

(2015) Xisheng Yan et al.   Journal of Neuroinflammation

Selective Activation of Microglia Facilitates Synaptic Strength

(2015) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Upregulation of α2δ−1 Calcium Channel Subunit in the Spinal Cord Contributes to Pelvic Organ Cross-Sensitization in a Rat Model of Experimentally-Induced Endometriosis

(2015) Yun Wang et al.   NEUROCHEMICAL RESEARCH

Pelvic organ cross-sensitization to enhance bladder and urethral pain behaviors in rats with experimental colitis

(2015) S. Yoshikawa et al.   NEUROSCIENCE

Activation of p38 MAPK in the rostral ventromedial medulla by visceral noxious inputs transmitted via the dorsal columns may contribute to pelvic organ cross-sensitization in rats with endometriosis

(2015) Z. Chen et al.   NEUROSCIENCE

Neuropathic pain depends upon d-serine co-activation of spinal NMDA receptors in rats

(2015) Yan Lefèvre et al.   NEUROSCIENCE LETTERS

Neonatal vaginal irritation results in long-term visceral and somatic hypersensitivity and increased hypothalamic–pituitary–adrenal axis output in female mice

(2015) Angela N. Pierce et al.   PAIN

Inflammation-induced pain sensitization in men and women

(2015) Alexander Wegner et al.   PAIN

Inflammation and nerve fiber interaction in endometriotic pain

(2015) Brett D. McKinnon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Menstruation pulls the trigger for inflammation and pain in endometriosis

(2015) Alexis Laux-Biehlmann et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Calcitonin Gene-Related Peptide-Expressing Sensory Neurons and Spinal Microglial Reactivity Contribute to Pain States in Collagen-Induced Arthritis

(2015) Francisco R. Nieto et al.   Arthritis & Rheumatology

Neuron-glial communication mediated by TNF-α and glial activation in dorsal root ganglia in visceral inflammatory hypersensitivity

(2014) Dan-dan Song et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Positive Feedback Loop of Autocrine BDNF from Microglia Causes Prolonged Microglia Activation

(2014) Xin Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Analgesic effect of minocycline in rat model of inflammation-induced visceral pain

(2014) Pradeep Kannampalli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Over-expression of P2X7 receptors in spinal glial cells contributes to the development of chronic postsurgical pain induced by skin/muscle incision and retraction (SMIR) in rats

(2014) Yan-Lu Ying et al.   EXPERIMENTAL NEUROLOGY

P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia

(2014) Chu-Hsin Shieh et al.   GLIA

Central changes associated with chronic pelvic pain and endometriosis

(2014) Jennifer Brawn et al.   HUMAN REPRODUCTION UPDATE

Peripheral changes in endometriosis-associated pain

(2014) Matteo Morotti et al.   HUMAN REPRODUCTION UPDATE

Emerging targets in neuroinflammation-driven chronic pain

(2014) Ru-Rong Ji et al.   NATURE REVIEWS DRUG DISCOVERY

Vaginal hypersensitivity and hypothalamic–pituitary–adrenal axis dysfunction as a result of neonatal maternal separation in female mice

(2014) A.N. Pierce et al.   NEUROSCIENCE

Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis

(2014) Nilesh M. Agalave et al.   PAIN

Inflammation and inflammatory control in interstitial cystitis/bladder pain syndrome: Associations with painful symptoms

(2014) Andrew Schrepf et al.   PAIN

Experimental autoimmune prostatitis induces microglial activation in the spinal cord

(2014) Larry Wong et al.   PROSTATE

Lost but making progress--Where will new analgesic drugs come from?

(2014) D. Borsook et al.   Science Translational Medicine

Neurobiological Mechanisms of Pelvic Pain

(2014) Massimo Origoni et al.   Biomed Research International

Changes in protein expression and distribution of spinal CCR2 in a rat model of bone cancer pain

(2013) Ji-Hua Hu et al.   BRAIN RESEARCH

Importance of glial activation in neuropathic pain

(2013) Joanna Mika et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Astrocytes—Multitaskers in chronic pain

(2013) Rikke Rie Hansen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sex differences and hormonal modulation of deep tissue pain

(2013) Richard J. Traub et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Estrogenic influences in pain processing

(2013) Åsa Amandusson et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Prevalence of endometriosis diagnosed by laparoscopy in adolescents with dysmenorrhea or chronic pelvic pain: a systematic review

(2013) E.B. Janssen et al.   HUMAN REPRODUCTION UPDATE

Increased Expression of Pattern Recognition Receptors and Nitric Oxide Synthase in Patients with Endometriosis

(2013) Seung Geun Yeo et al.   International Journal of Medical Sciences

Endogenous Interleukin-1β in Neuropathic Rats Enhances Glutamate Release from the Primary Afferents in the Spinal Dorsal Horn through Coupling with PresynapticN-Methyl-d-aspartic Acid Receptors

(2013) Xisheng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice

(2013) Jennifer A Stokes et al.   Journal of Neuroinflammation

Induction of Thermal Hyperalgesia and Synaptic Long-Term Potentiation in the Spinal Cord Lamina I by TNF-  and IL-1  is Mediated by Glial Cells

(2013) D. Gruber-Schoffnegger et al.   JOURNAL OF NEUROSCIENCE

Spinal astrocytes stimulated by tumor necrosis factor-α and/or interferon-γ attenuate connexin 43-gap junction via c-jun terminal kinase activity

(2013) Fang Fang Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Toll-like receptor system and endometriosis

(2013) Khaleque Newaz Khan et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Spinal microglia: A potential target in the treatment of chronic visceral pain

(2013) Ching-Liang Lu   Journal of the Chinese Medical Association

Enhancement by Interleukin-1β of AMPA and NMDA Receptor-Mediated Currents in Adult Rat Spinal Superficial Dorsal Horn Neurons

(2013) Tao Liu et al.   Molecular Pain

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

(2013) Dimitris N. Xanthos et al.   NATURE REVIEWS NEUROSCIENCE

The activation of P2Y6 receptor in cultured spinal microglia induces the production of CCL2 through the MAP kinases-NF-κB pathway

(2013) Norimitsu Morioka et al.   NEUROPHARMACOLOGY

Multiple Roles for Astrocytes as Effectors of Cytokines and Inflammatory Mediators

(2013) Michael V. Sofroniew   NEUROSCIENTIST

Glia and pain: Is chronic pain a gliopathy?

(2013) Ru-Rong Ji et al.   PAIN

TLR 2 and 4 Responsiveness from Isolated Peripheral Blood Mononuclear Cells from Rats and Humans as Potential Chronic Pain Biomarkers

(2013) Yuen H. Kwok et al.   PLoS One

Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain

(2013) Sarah Taves et al.   NEURAL PLASTICITY

Endometriosis, a disease of the macrophage

(2013) Annalisa Capobianco   Frontiers in Immunology

High-mobility group box 1 contributes to mechanical allodynia and spinal astrocytic activation in a mouse model of type 2 diabetes

(2012) Peng-Cheng Ren et al.   BRAIN RESEARCH BULLETIN

Glial glutamate transporter and glutamine synthetase regulate GABAergic synaptic strength in the spinal dorsal horn

(2012) Enshe Jiang et al.   JOURNAL OF NEUROCHEMISTRY

The Prevalence and Overlap of Interstitial Cystitis/Bladder Pain Syndrome and Chronic Prostatitis/Chronic Pelvic Pain Syndrome in Men: Results of the RAND Interstitial Cystitis Epidemiology Male Study

(2012) Anne M. Suskind et al.   JOURNAL OF UROLOGY

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

(2012) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats

(2012) Lisa C. Loram et al.   PSYCHONEUROENDOCRINOLOGY

CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia

(2012) Emika Toyomitsu et al.   Purinergic Signalling

Immunological Aspects of Endometriosis: An Update

(2011) Matts Olovsson   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Priming of adult pain responses by neonatal pain experience: maintenance by central neuroimmune activity

(2011) Simon Beggs et al.   BRAIN

Chemokine mediated neuron–glia communication and aberrant signalling in neuropathic pain states

(2011) Elizabeth Amy Old et al.   CURRENT OPINION IN PHARMACOLOGY

Toll-like receptors in chronic pain

(2011) Lauren Nicotra et al.   EXPERIMENTAL NEUROLOGY

Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice

(2011) R. E. Sorge et al.   JOURNAL OF NEUROSCIENCE

Prevalence of Symptoms of Bladder Pain Syndrome/Interstitial Cystitis Among Adult Females in the United States

(2011) Sandra H. Berry et al.   JOURNAL OF UROLOGY

Cancer-Induced Bone Pain Sequentially Activates the ERK/MAPK Pathway in Different Cell Types in the Rat Spinal Cord

(2011) Li-Na Wang et al.   Molecular Pain

Calcitonin Gene-Related Peptide Promotes Cellular Changes in Trigeminal Neurons and Glia Implicated in Peripheral and Central Sensitization

(2011) Ryan J Cady et al.   Molecular Pain

Neonatal cystitis-induced colonic hypersensitivity in adult rats: a model of viscero-visceral convergence

(2011) A. Miranda et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model

(2011) Kimiko Kobayashi et al.   NEUROSCIENCE LETTERS

Spinal estrogen receptor alpha mediates estradiol-induced pronociception in a visceral pain model in the rat

(2011) Yaping Ji et al.   PAIN

Spinal high-mobility group box 1 contributes to mechanical allodynia in a rat model of bone cancer pain

(2010) Wei Tong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of sensory neurons in colitis: increasing evidence for a neuroimmune link in the gut

(2010) Matthias A. Engel et al.   INFLAMMATORY BOWEL DISEASES

17 -Estradiol Promotes TLR4-Triggered Proinflammatory Mediator Production through Direct Estrogen Receptor   Signaling in Macrophages In Vivo

(2010) B. Calippe et al.   JOURNAL OF IMMUNOLOGY

A p38 Mitogen-Activated Protein Kinase-Dependent Mechanism of Disinhibition in Spinal Synaptic Transmission Induced by Tumor Necrosis Factor- 

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Pain Intensity and Duration Can Be Enhanced by Prior Challenge: Initial Evidence Suggestive of a Role of Microglial Priming

(2010) Leah E. Hains et al.   JOURNAL OF PAIN

Effect of Estrogen on Bladder Nociception in Rats

(2010) Meredith T. Robbins et al.   JOURNAL OF UROLOGY

Opioid Blockade and Inflammation Reveal Estrous Cycle Effects on Visceromotor Reflexes Evoked by Bladder Distention

(2010) Chelsea L. Ball et al.   JOURNAL OF UROLOGY

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

(2010) Zhen-Zhong Xu et al.   NATURE MEDICINE

Activation of the neurokinin-1 receptor in rat spinal astrocytes induces Ca2+ release from IP3-sensitive Ca2+ stores and extracellular Ca2+ influx through TRPC3

(2010) Kanako Miyano et al.   NEUROCHEMISTRY INTERNATIONAL

Spinal TRPA1 ion channels contribute to cutaneous neurogenic inflammation in the rat

(2010) Hong Wei et al.   NEUROSCIENCE LETTERS

Neonatal bladder inflammation alters activity of adult rat spinal visceral nociceptive neurons

(2010) T.J. Ness et al.   NEUROSCIENCE LETTERS

Targeting astrocyte signaling for chronic pain

(2010) Yong-Jing Gao et al.   Neurotherapeutics

Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior

(2010) Jeong Il Choi et al.   PAIN

Microglial/macrophage GRK2 determines duration of peripheral IL-1β-induced hyperalgesia: Contribution of spinal cord CX3CR1, p38 and IL-1 signaling

(2010) Hanneke L.D.M. Willemen et al.   PAIN

The necessity of animal models in pain research

(2010) Jeffrey S. Mogil et al.   PAIN

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Estrogen-dependent changes in visceral afferent sensitivity

(2009) Raul Sanoja et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Gap junctions in dorsal root ganglia: Possible contribution to visceral pain

(2009) Tian-Ying Huang et al.   EUROPEAN JOURNAL OF PAIN

Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve injury through the activation of p38 MAPK

(2009) Kyung-Min Lee et al.   EUROPEAN JOURNAL OF PAIN

JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain

(2009) Y.-J. Gao et al.   JOURNAL OF NEUROSCIENCE

Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings

(2009) Roger B. Fillingim et al.   JOURNAL OF PAIN

Plasticity in Expression of the Glutamate Transporters GLT-1 and GLAST in Spinal Dorsal Horn Glial Cells following Partial Sciatic Nerve Ligation

(2009) Wen-Jun Xin et al.   Molecular Pain

Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats

(2009) M.R. Hutchinson et al.   NEUROSCIENCE

Beyond neurons: Involvement of urothelial and glial cells in bladder function

(2009) Lori A. Birder et al.   NEUROUROLOGY AND URODYNAMICS

IFN-  receptor signaling mediates spinal microglia activation driving neuropathic pain

(2009) M. Tsuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

REVIEW ARTICLE: Immunopathogenesis of Pelvic Endometriosis: Role of Hepatocyte Growth Factor, Macrophages and Ovarian Steroids

(2008) Khaleque Newaz Khan et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Spinal interleukin-1β in a mouse model of arthritis and joint pain

(2008) Paolo M. Fiorentino et al.   ARTHRITIS AND RHEUMATISM

Purinergic systems in microglia

(2008) K. Inoue   CELLULAR AND MOLECULAR LIFE SCIENCES

CCL2 is a key mediator of microglia activation in neuropathic pain states

(2008) Michael A. Thacker et al.   EUROPEAN JOURNAL OF PAIN

Fibronectin/integrin system is involved in P2X4 receptor upregulation in the spinal cord and neuropathic pain after nerve injury

(2008) Makoto Tsuda et al.   GLIA

Toll-like receptor 4-mediated growth of endometriosis by human heat-shock protein 70

(2008) K. N. Khan et al.   HUMAN REPRODUCTION

Prevalence of chronic prostatitis symptoms in a randomly surveyed adult population of urban-community-dwelling Nigerian males

(2008) Chukwunonso ECC Ejike et al.   INTERNATIONAL JOURNAL OF UROLOGY

P2Y1receptor-mediated glutamate release from cultured dorsal spinal cord astrocytes

(2008) Jun-Wei Zeng et al.   JOURNAL OF NEUROCHEMISTRY

P2Y12 Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury

(2008) H. Tozaki-Saitoh et al.   JOURNAL OF NEUROSCIENCE

P2Y12 Receptor Upregulation in Activated Microglia Is a Gateway of p38 Signaling and Neuropathic Pain

(2008) K. Kobayashi et al.   JOURNAL OF NEUROSCIENCE

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE

Up-Regulation of P2X4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

(2008) L. Ulmann et al.   JOURNAL OF NEUROSCIENCE

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

(2008) Yasuhiko Kawasaki et al.   NATURE MEDICINE

Pathological and protective roles of glia in chronic pain

(2008) Erin D. Milligan et al.   NATURE REVIEWS NEUROSCIENCE

The visceromotor response to colorectal distention fluctuates with the estrous cycle in rats

(2008) Y. Ji et al.   NEUROSCIENCE

Estrogen alters spinal NMDA receptor activity via a PKA signaling pathway in a visceral pain model in the rat

(2008) Bin Tang et al.   PAIN

Microglial activation and TNF  production mediate altered CNS excitability following peripheral inflammation

(2008) K. Riazi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR3 and TLR4 expression in healthy and diseased human endometrium

(2008) Svenja Allhorn et al.   Reproductive Biology and Endocrinology

IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats

(2007) Rui-Xin Zhang et al.   PAIN