Modulating the Substrate Stiffness to Manipulate Differentiation of Resident Liver Stem Cells and to Improve the Differentiation State of Hepatocytes

Application of biomaterials to advance induced pluripotent stem cell research and therapy

(2015) Z. Tong et al.   EMBO JOURNAL

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression

(2015) Julien Fitamant et al.   Cell Reports

Reprogramming with Small Molecules instead of Exogenous Transcription Factors

(2015) Tongxiang Lin et al.   Stem Cells International

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation

(2014) Kilangsungla Yanger et al.   Cell Stem Cell

Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury

(2014) Johanna R. Schaub et al.   Cell Reports

Hippo Signaling Influences HNF4A and FOXA2 Enhancer Switching during Hepatocyte Differentiation

(2014) Olivia Alder et al.   Cell Reports

Evidence for a common progenitor of epithelial and mesenchymal components of the liver

(2013) A Conigliaro et al.   CELL DEATH AND DIFFERENTIATION

Substrate stiffness regulates solubility of cellular vimentin

(2013) Maria E. Murray et al.   MOLECULAR BIOLOGY OF THE CELL

Biophysical regulation of epigenetic state and cell reprogramming

(2013) Timothy L. Downing et al.   NATURE MATERIALS

Production of hepatocyte-like cells from human pluripotent stem cells

(2013) Nicholas R F Hannan et al.   Nature Protocols

Switch Enhancers Interpret TGF-β and Hippo Signaling to Control Cell Fate in Human Embryonic Stem Cells

(2013) Tobias A. Beyer et al.   Cell Reports

Human liver stem cells improve liver injury in a model of fulminant liver failure

(2012) Maria Beatriz Herrera et al.   HEPATOLOGY

Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming

(2012) Han Qin et al.   HUMAN MOLECULAR GENETICS

Mechanosensitive mechanisms in transcriptional regulation

(2012) Akiko Mammoto et al.   JOURNAL OF CELL SCIENCE

Soft fibrin gels promote selection and growth of tumorigenic cells

(2012) Jing Liu et al.   NATURE MATERIALS

MyoD regulates p57 kip2 expression by interacting with a distant cis -element and modifying a higher order chromatin structure

(2012) Anna Busanello et al.   NUCLEIC ACIDS RESEARCH

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Influence of stress on extracellular matrix and integrin biology

(2011) C Jean et al.   ONCOGENE

The new murine hepatic 3A cell line responds to stress stimuli by activating an efficient Unfolded Protein Response (UPR)

(2011) Barbara Guantario et al.   TOXICOLOGY IN VITRO

The epigenetic mechanism of mechanically induced osteogenic differentiation

(2010) Emily J. Arnsdorf et al.   JOURNAL OF BIOMECHANICS

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Mammary Epithelial-Specific Disruption of Focal Adhesion Kinase Retards Tumor Formation and Metastasis in a Transgenic Mouse Model of Human Breast Cancer

(2008) Paolo P. Provenzano et al.   AMERICAN JOURNAL OF PATHOLOGY

Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia

(2008) Jordi Alcaraz et al.   EMBO JOURNAL

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Towards an Extended Functional Hepatocyte In Vitro Culture

(2008) Joana P. Miranda et al.   TISSUE ENGINEERING PART C-METHODS