Reprogramming with Small Molecules instead of Exogenous Transcription Factors

Identification of a Small Molecule That Turns ON the Pluripotency Gene Circuitry in Human Fibroblasts

(2014) Ganesh N. Pandian et al.   ACS Chemical Biology

Platform for Induction and Maintenance of Transgene-free hiPSCs Resembling Ground State Pluripotent Stem Cells

(2014) Bahram Valamehr et al.   Stem Cell Reports

Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers

(2013) Jian Shu et al.   CELL

Wnt signaling in stem and cancer stem cells

(2013) Jane D Holland et al.   CURRENT OPINION IN CELL BIOLOGY

Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds

(2013) P. Hou et al.   SCIENCE

A Novel Small Molecule Facilitates the Reprogramming of Human Somatic Cells into a Pluripotent State and Supports the Maintenance of an Undifferentiated State of Human Pluripotent Stem Cells

(2012) Jungwoon Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cellular reprogramming: a small molecule perspective

(2012) Baoming Nie et al.   CURRENT OPINION IN CELL BIOLOGY

Stem Cells: Flexible friends

(2012) Nirupama Shevde   NATURE

The promise of induced pluripotent stem cells in research and therapy

(2012) Daisy A. Robinton et al.   NATURE

Efficient Generation of Virus-Free iPS Cells Using Liposomal Magnetofection

(2012) Hyo Young Park et al.   PLoS One

Contribution of Hepatic Lineage Stage-Specific Donor Memory to the Differential Potential of Induced Mouse Pluripotent Stem Cells

(2012) Seung Bum Lee et al.   STEM CELLS

A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation

(2012) Zhonghan Li et al.   Nature Communications

A Small Molecule Mimicking a Phosphatidylinositol (4,5)-Bisphosphate Binding Pleckstrin Homology Domain

(2011) Lok Hang Mak et al.   ACS Chemical Biology

Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells

(2011) Taotao Chen et al.   AGING CELL

Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells

(2011) Judith Staerk et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reprogramming fibroblasts into induced pluripotent stem cells with Bmi1

(2011) Jai-Hee Moon et al.   CELL RESEARCH

Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature

(2011) Huansheng Xu et al.   CELL RESEARCH

Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells

(2011) Quan Wang et al.   CELL RESEARCH

Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells

(2011) Ori Bar-Nur et al.   Cell Stem Cell

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

(2011) Ryan Lister et al.   NATURE

Immunogenicity of induced pluripotent stem cells

(2011) Tongbiao Zhao et al.   NATURE

Wnt: What's Needed To maintain pluripotency?

(2011) Hitoshi Niwa   NATURE CELL BIOLOGY

Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells

(2011) Yuki Ohi et al.   NATURE CELL BIOLOGY

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Efficient Non-Viral Reprogramming of Myoblasts to Stemness with a Single Small Molecule to Generate Cardiac Progenitor Cells

(2011) Zeeshan Pasha et al.   PLoS One

T-cell factor 3 (Tcf3) deletion increases somatic cell reprogramming by inducing epigenome modifications

(2011) F. Lluis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brief Report: Combined Chemical Treatment Enables Oct4-Induced Reprogramming from Mouse Embryonic Fibroblasts

(2011) Xu Yuan et al.   STEM CELLS

Patient-Specific Pluripotent Stem Cells in Neurological Diseases

(2011) Serpen Durnaoglu et al.   Stem Cells International

Generation of iPSCs from mouse fibroblasts with a single gene, Oct4 and small molecules

(2010) Yanqin Li et al.   CELL RESEARCH

Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds

(2010) Saiyong Zhu et al.   Cell Stem Cell

Distinct Epigenomic Landscapes of Pluripotent and Lineage-Committed Human Cells

(2010) R. David Hawkins et al.   Cell Stem Cell

Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells

(2010) Miguel Angel Esteban et al.   Cell Stem Cell

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

(2010) Payman Samavarchi-Tehrani et al.   Cell Stem Cell

A nonviral minicircle vector for deriving human iPS cells

(2010) Fangjun Jia et al.   NATURE METHODS

The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells

(2010) Alessandro Prigione et al.   STEM CELLS

Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency-Associated Genes

(2010) Prashant Mali et al.   STEM CELLS

Role of the Murine Reprogramming Factors in the Induction of Pluripotency

(2009) Rupa Sridharan et al.   CELL

Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells

(2009) Yoshinori Yoshida et al.   Cell Stem Cell

A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog

(2009) Justin K. Ichida et al.   Cell Stem Cell

Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins

(2009) Dohoon Kim et al.   Cell Stem Cell

Induced Pluripotent Stem Cells and Embryonic Stem Cells Are Distinguished by Gene Expression Signatures

(2009) Mark H. Chin et al.   Cell Stem Cell

Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins

(2009) Hongyan Zhou et al.   Cell Stem Cell

Senescence impairs successful reprogramming to pluripotent stem cells

(2009) A. Banito et al.   GENES & DEVELOPMENT

ROCK inhibition enhances the recovery and growth of cryopreserved human embryonic stem cells and human induced pluripotent stem cells

(2009) David A. Claassen et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

The promises and perils of p53

(2009) Valery Krizhanovsky et al.   NATURE

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

(2009) Teruhisa Kawamura et al.   NATURE

Virus-free induction of pluripotency and subsequent excision of reprogramming factors

(2009) Keisuke Kaji et al.   NATURE

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

(2009) Knut Woltjen et al.   NATURE

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

(2009) Rosa M. Marión et al.   NATURE

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

(2009) Hyenjong Hong et al.   NATURE

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

(2009) Jochen Utikal et al.   NATURE

The Ink4/Arf locus is a barrier for iPS cell reprogramming

(2009) Han Li et al.   NATURE

A chemical platform for improved induction of human iPSCs

(2009) Tongxiang Lin et al.   NATURE METHODS

Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

(2009) Noemi FUSAKI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4

(2009) C. A. Lyssiotis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

(2009) J. Yu et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Generation of Human Induced Pluripotent Stem Cells in the Absence of ExogenousSox2

(2009) Wenlin Li et al.   STEM CELLS

Adenoviral Gene Delivery Can Reprogram Human Fibroblasts to Induced Pluripotent Stem Cells

(2009) Wenbo Zhou et al.   STEM CELLS

A Combined Chemical and Genetic Approach for the Generation of Induced Pluripotent Stem Cells

(2008) Yan Shi et al.   Cell Stem Cell

Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation

(2008) Yang Zhao et al.   Cell Stem Cell

Wnt Signaling Promotes Reprogramming of Somatic Cells to Pluripotency

(2008) Alexander Marson et al.   Cell Stem Cell

Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds

(2008) Yan Shi et al.   Cell Stem Cell

From fibroblasts to iPS cells: Induced pluripotency by defined factors

(2008) Rui Zhao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dissecting direct reprogramming through integrative genomic analysis

(2008) Tarjei S. Mikkelsen et al.   NATURE

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

(2008) Danwei Huangfu et al.   NATURE BIOTECHNOLOGY

Induced Pluripotent Stem Cells Generated Without Viral Integration

(2008) M. Stadtfeld et al.   SCIENCE

Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors

(2008) K. Okita et al.   SCIENCE