Synaptic Wnt/GSK3βSignaling Hub in Autism

Molecular mechanisms of epilepsy

(2015) Kevin Staley   NATURE NEUROSCIENCE

Wnt/β-Catenin Signaling in Alzheimer’s Disease

(2014) Giancarlo Ferrari et al.   CNS & Neurological Disorders-Drug Targets

The discovery of integrated gene networks for autism and related disorders

(2014) Fereydoun Hormozdiari et al.   GENOME RESEARCH

Common variants in genes of the postsynaptic FMRP signalling pathway are risk factors for autism spectrum disorders

(2014) Regina Waltes et al.   HUMAN GENETICS

Sulindac attenuates valproic acid-induced oxidative stress levels in primary cultured cortical neurons and ameliorates repetitive/stereotypic-like movement disorders in Wistar rats prenatally exposed to valproic acid

(2014) YINGHUA ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Preliminary Investigation of Lithium for Mood Disorder Symptoms in Children and Adolescents with Autism Spectrum Disorder

(2014) Matthew Siegel et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities

(2014) J L Mohn et al.   MOLECULAR PSYCHIATRY

Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin

(2014) S M Ochs et al.   MOLECULAR PSYCHIATRY

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

The contribution of de novo coding mutations to autism spectrum disorder

(2014) Ivan Iossifov et al.   NATURE

Disentangling the heterogeneity of autism spectrum disorder through genetic findings

(2014) Shafali S. Jeste et al.   Nature Reviews Neurology

Long-Term Memory Deficits are Associated with Elevated Synaptic ERK1/2 Activation and Reversed by mGluR5 Antagonism in an Animal Model of Autism

(2014) Ronald R Seese et al.   NEUROPSYCHOPHARMACOLOGY

Valproic acid selectively suppresses the formation of inhibitory synapses in cultured cortical neurons

(2014) Emi Kumamaru et al.   NEUROSCIENCE LETTERS

Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism

(2014) Kazuhiro Takuma et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Developmental neurotoxicity and anticonvulsant drugs: A possible link

(2014) A. Verrotti et al.   REPRODUCTIVE TOXICOLOGY

A de novo convergence of autism genetics and molecular neuroscience

(2014) Niklas Krumm et al.   TRENDS IN NEUROSCIENCES

2-Methyl-6-(phenylethynyl) pyridine (MPEP) reverses maze learning and PSD-95 deficits in Fmr1 knock-out mice

(2014) Réno M. Gandhi et al.   Frontiers in Cellular Neuroscience

Lithium ameliorates autistic-like behaviors induced by neonatal isolation in rats

(2014) Xiaoyan Wu et al.   Frontiers in Behavioral Neuroscience

SYN2 is an autism predisposing gene: loss-of-function mutations alter synaptic vesicle cycling and axon outgrowth

(2013) Anna Corradi et al.   HUMAN MOLECULAR GENETICS

CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses

(2013) Michael A Bemben et al.   NATURE NEUROSCIENCE

High-Throughput Genetic Screen for Synaptogenic Factors: Identification of LRP6 as Critical for Excitatory Synapse Development

(2013) Kamal Sharma et al.   Cell Reports

Autism-related behavioral abnormalities in synapsin knockout mice

(2012) Barbara Greco et al.   BEHAVIOURAL BRAIN RESEARCH

Cadherins and neuropsychiatric disorders

(2012) Christoph Redies et al.   BRAIN RESEARCH

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Individual common variants exert weak effects on the risk for autism spectrum disorders

(2012) Richard Anney et al.   HUMAN MOLECULAR GENETICS

Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway

(2012) J. Y. Hong et al.   JOURNAL OF CELL SCIENCE

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

(2012) Stephan J. Sanders et al.   NATURE

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Downregulating the Canonical Wnt/β-catenin Signaling Pathway Attenuates the Susceptibility to Autism-like Phenotypes by Decreasing Oxidative Stress

(2012) Yinghua Zhang et al.   NEUROCHEMICAL RESEARCH

Diagnostic Exome Sequencing in Persons with Severe Intellectual Disability

(2012) Joep de Ligt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selective deletion of forebrain glycogen synthase kinase 3  reveals a central role in serotonin-sensitive anxiety and social behaviour

(2012) C. Latapy et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Memory in autistic spectrum disorder.

(2012) Jill Boucher et al.   PSYCHOLOGICAL BULLETIN

Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders

(2012) B. J. O'Roak et al.   SCIENCE

Wnt Signaling and Forebrain Development

(2012) S. J. Harrison-Uy et al.   Cold Spring Harbor Perspectives in Biology

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

(2012) H. Y. Zoghbi et al.   Cold Spring Harbor Perspectives in Biology

A review of the evidence for the canonical Wnt pathway in autism spectrum disorders

(2012) Hans Kalkman   Molecular Autism

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse

(2011) Keisuke Kuroda et al.   HUMAN MOLECULAR GENETICS

SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function

(2011) Anna Fassio et al.   HUMAN MOLECULAR GENETICS

Inhibition of GSK3  improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome

(2011) W. Guo et al.   HUMAN MOLECULAR GENETICS

Synaptic Wnt signaling—a contributor to major psychiatric disorders?

(2011) Nathan D. Okerlund et al.   Journal of Neurodevelopmental Disorders

Synaptic Stimulation of mTOR Is Mediated by Wnt Signaling and Regulation of Glycogen Synthetase Kinase-3

(2011) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Regulation of NMDA-Receptor Synaptic Transmission by Wnt Signaling

(2011) W. Cerpa et al.   JOURNAL OF NEUROSCIENCE

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

(2011) Brian J O'Roak et al.   NATURE GENETICS

Lithium reverses increased rates of cerebral protein synthesis in a mouse model of fragile X syndrome

(2011) Zhong-Hua Liu et al.   NEUROBIOLOGY OF DISEASE

Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development

(2011) Karun K. Singh et al.   NEURON

Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders

(2011) Dan Levy et al.   NEURON

Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism

(2011) Stephan J. Sanders et al.   NEURON

Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling

(2011) A Gupta et al.   PHARMACOGENOMICS JOURNAL

Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca2+/Calmodulin-dependent protein kinase II

(2011) L. Ciani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Demethylation of Specific Wnt/β-Catenin Pathway Genes and its Upregulation in Rat Brain Induced by Prenatal Valproate Exposure

(2010) Zhongping Wang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Genome-wide identification of new Wnt/β-catenin target genes in the human genome using CART method

(2010) Christian Hödar et al.   BMC GENOMICS

Etiological heterogeneity in autism spectrum disorders: More than 100 genetic and genomic disorders and still counting

(2010) Catalina Betancur   BRAIN RESEARCH

Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder

(2010) John LR Rubenstein   CURRENT OPINION IN NEUROLOGY

Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome

(2010) Zhong-Hua Liu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Canonical Wnt3a Modulates Intracellular Calcium and Enhances Excitatory Neurotransmission in Hippocampal Neurons

(2010) Miguel E. Avila et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fragile X mice: Reduced long-term potentiation and N-Methyl-D-Aspartate receptor-mediated neurotransmission in dentate gyrus

(2010) Sung Hwan Yun et al.   JOURNAL OF NEUROSCIENCE RESEARCH

GSK3 signalling in neural development

(2010) Eun-Mi Hur et al.   NATURE REVIEWS NEUROSCIENCE

GSK3 Influences Social Preference and Anxiety-Related Behaviors during Social Interaction in a Mouse Model of Fragile X Syndrome and Autism

(2010) Marjelo A. Mines et al.   PLoS One

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

(2010) S. A. Ettenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses

(2010) L. Varela-Nallar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The synapsins: Key actors of synapse function and plasticity

(2010) F. Cesca et al.   PROGRESS IN NEUROBIOLOGY

Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3

(2010) Tatiana V. Lipina et al.   SYNAPSE

Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells

(2010) Yuping Luo et al.   PLoS Genetics

Characteristics and Concordance of Autism Spectrum Disorders Among 277 Twin Pairs

(2009) Rebecca E. Rosenberg et al.   ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE

Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of Fragile X syndrome

(2009) Christopher J. Yuskaitis et al.   BIOCHEMICAL PHARMACOLOGY

A Computational Model for Cerebral Cortical Dysfunction in Autism Spectrum Disorders

(2009) Shashaank Vattikuti et al.   BIOLOGICAL PSYCHIATRY

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

DISC1duplication in two brothers with autism and mild mental retardation

(2009) A Crepel et al.   CLINICAL GENETICS

Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/β-catenin signaling pathway

(2009) Macarena S. Arrázola et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Scribble Interacts with β-Catenin to Localize Synaptic Vesicles to Synapses

(2009) Yu Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Emerging roles of Wnts in the adult nervous system

(2009) Nibaldo C. Inestrosa et al.   NATURE REVIEWS NEUROSCIENCE

Communication Between the Synapse and the Nucleus in Neuronal Development, Plasticity, and Disease

(2008) Sonia Cohen et al.   Annual Review of Cell and Developmental Biology

Cyclooxygenase-2 Inhibition Inhibits c-Met Kinase Activity and Wnt Activity in Colon Cancer

(2008) J. B. Tuynman et al.   CANCER RESEARCH

Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEP

(2008) Justin T. Gass et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and β-catenin

(2008) Seung-Hye Lee et al.   JOURNAL OF CELL BIOLOGY

Signalling by neurotrophins and hepatocyte growth factor regulates axon morphogenesis by differential  -catenin phosphorylation

(2008) M. D. David et al.   JOURNAL OF CELL SCIENCE

CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates  -Catenin Target Genes

(2008) B. A. Thompson et al.   MOLECULAR AND CELLULAR BIOLOGY

Advances in autism genetics: on the threshold of a new neurobiology

(2008) Brett S. Abrahams et al.   NATURE REVIEWS GENETICS

Association study of GSK3 gene polymorphisms with schizophrenia and clozapine response

(2008) Renan P. Souza et al.   PSYCHOPHARMACOLOGY

The Mood-Stabilizing Agent Valproate Inhibits the Activity of Glycogen Synthase Kinase-3

(2003) Guang Chen et al.   JOURNAL OF NEUROCHEMISTRY