Cellular modulation by the elasticity of biomaterials

Combinational effect of matrix elasticity and alendronate density on differentiation of rat mesenchymal stem cells

(2015) Pengfei Jiang et al.   Acta Biomaterialia

Complete pulpodentin complex regeneration by modulating the stiffness of biomimetic matrix

(2015) Tiejun Qu et al.   Acta Biomaterialia

Molecularly Engineered Biodegradable Polymer Networks with a Wide Range of Stiffness for Bone and Peripheral Nerve Regeneration

(2015) Shanfeng Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Decreasing matrix modulus of PEG hydrogels induces a vascular phenotype in human cord blood stem cells

(2015) Shruthi Mahadevaiah et al.   BIOMATERIALS

Creating stiffness gradient polyvinyl alcohol hydrogel using a simple gradual freezing–thawing method to investigate stem cell differentiation behaviors

(2015) Tae Ho Kim et al.   BIOMATERIALS

The Effect of Substrate Stiffness, Thickness, and Cross-Linking Density on Osteogenic Cell Behavior

(2015) Conleth A. Mullen et al.   BIOPHYSICAL JOURNAL

Covalent conjugation of mechanically stiff graphene oxide flakes to three-dimensional collagen scaffolds for osteogenic differentiation of human mesenchymal stem cells

(2015) Seokyung Kang et al.   CARBON

Substrate elasticity modulates the responsiveness of mesenchymal stem cells to commitment cues

(2015) S. Gobaa et al.   Integrative Biology

Gene expression modulation in TGF-β3-mediated rabbit bone marrow stem cells using electrospun scaffolds of various stiffness

(2015) Qianping Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Extracellular matrix presentation modulates vascular smooth muscle cell mechanotransduction

(2015) Olga V. Sazonova et al.   MATRIX BIOLOGY

Dynamic phototuning of 3D hydrogel stiffness

(2015) Ryan S. Stowers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors

(2015) Francois Bordeleau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of regulation of stem cell differentiation by matrix stiffness

(2015) Hongwei Lv et al.   Stem Cell Research & Therapy

Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells

(2015) Akon Higuchi et al.   Journal of Materials Chemistry B

Optimum 3D Matrix Stiffness for Maintenance of Cancer Stem Cells Is Dependent on Tissue Origin of Cancer Cells

(2015) Esmaiel Jabbari et al.   PLoS One

Substrate Stiffness Together with Soluble Factors Affects Chondrocyte Mechanoresponses

(2014) Cheng Chen et al.   ACS Applied Materials & Interfaces

Highly Tunable Elastomeric Silk Biomaterials

(2014) Benjamin P. Partlow et al.   ADVANCED FUNCTIONAL MATERIALS

The combined effects of matrix stiffness and growth factor immobilization on the bioactivity and differentiation capabilities of adipose-derived stem cells

(2014) Jessica M. Banks et al.   BIOMATERIALS

The regulation of β-adrenergic receptor-mediated PKA activation by substrate stiffness via microtubule dynamics in human MSCs

(2014) Tae-Jin Kim et al.   BIOMATERIALS

The synergetic effect of hydrogel stiffness and growth factor on osteogenic differentiation

(2014) ShihJye Tan et al.   BIOMATERIALS

A tunable silk–alginate hydrogel scaffold for stem cell culture and transplantation

(2014) Keren Ziv et al.   BIOMATERIALS

Adipocyte Stiffness Increases with Accumulation of Lipid Droplets

(2014) Naama Shoham et al.   BIOPHYSICAL JOURNAL

Stiffness of the surrounding tissue of breast lesions evaluated by ultrasound elastography

(2014) JianQiao Zhou et al.   EUROPEAN RADIOLOGY

Controlling cell geometry on substrates of variable stiffness can tune the degree of osteogenesis in human mesenchymal stem cells

(2014) Junmin Lee et al.   Journal of the Mechanical Behavior of Biomedical Materials

Materials as stem cell regulators

(2014) William L. Murphy et al.   NATURE MATERIALS

ECM stiffness paves the way for tumor cells

(2014) Victoria Seewaldt   NATURE MEDICINE

Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression

(2014) Janna K Mouw et al.   NATURE MEDICINE

Regional Variations in the Cellular, Biochemical, and Biomechanical Characteristics of Rabbit Annulus Fibrosus

(2014) Jun Li et al.   PLoS One

Identification of Rabbit Annulus Fibrosus-Derived Stem Cells

(2014) Chen Liu et al.   PLoS One

Microenvironmental Stiffness Enhances Glioma Cell Proliferation by Stimulating Epidermal Growth Factor Receptor Signaling

(2014) Vaibhavi Umesh et al.   PLoS One

Kinetic behaviour of the cells touching substrate: the interfacial stiffness guides cell spreading

(2014) Jianjun Li et al.   Scientific Reports

Biomaterial arrays with defined adhesion ligand densities and matrix stiffness identify distinct phenotypes for tumorigenic and non-tumorigenic human mesenchymal cell types

(2014) Tyler D. Hansen et al.   Biomaterials Science

Silk nanofiber hydrogels with tunable modulus to regulate nerve stem cell fate

(2014) ShuMeng Bai et al.   Journal of Materials Chemistry B

Extracellular Matrix Structure and Tissue Stiffness Control Postnatal Lung Development through the Lipoprotein Receptor–Related Protein 5/Tie2 Signaling System

(2013) Tadanori Mammoto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Differential regulation of stiffness, topography, and dimension of substrates in rat mesenchymal stem cells

(2013) Zhan Li et al.   BIOMATERIALS

The effect of mesenchymal stem cell shape on the maintenance of multipotency

(2013) Douglas Zhang et al.   BIOMATERIALS

Effect of BMP-2 from matrices of different stiffnesses for the modulation of stem cell fate

(2013) Omar F. Zouani et al.   BIOMATERIALS

Stimulation of adipogenesis of adult adipose-derived stem cells using substrates that mimic the stiffness of adipose tissue

(2013) D. Adam Young et al.   BIOMATERIALS

Physical Cues of Biomaterials Guide Stem Cell Differentiation Fate

(2013) Akon Higuchi et al.   CHEMICAL REVIEWS

Effect of substrate stiffness on the functions of rat bone marrow and adipose tissue derived mesenchymal stem cells in vitro

(2013) Xiaoming Li et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Osteogenic differentiation of human mesenchymal stem cells on α5 integrin binding peptide hydrogels is dependent on substrate elasticity

(2013) Navakanth R. Gandavarapu et al.   Biomaterials Science

Compressive elasticity of three-dimensional nanofiber matrix directs mesenchymal stem cell differentiation to vascular cells with endothelial or smooth muscle cell markers

(2012) K. Wingate et al.   Acta Biomaterialia

Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior

(2012) Brooke N. Mason et al.   Acta Biomaterialia

Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages

(2012) Goh Jih Her et al.   Acta Biomaterialia

The influence of substrate stiffness on the behavior and functions of Schwann cells in culture

(2012) Yun Gu et al.   BIOMATERIALS

The effect of substrate modulus on the growth and function of matrix-embedded endothelial cells

(2012) Sylaja Murikipudi et al.   BIOMATERIALS

Tumor cell migration in complex microenvironments

(2012) William J. Polacheck et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Control of stem cell fate and function by engineering physical microenvironments

(2012) Kshitiz et al.   Integrative Biology

Differential effects of substrate modulus on human vascular endothelial, smooth muscle, and fibroblastic cells

(2012) Karyn G. Robinson et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation

(2012) Jessica L. Allen et al.   MOLECULAR BIOLOGY OF THE CELL

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Real-Time Visualization and Quantitation of Vascular Permeability In Vivo: Implications for Drug Delivery

(2012) Desmond B. S. Pink et al.   PLoS One

Cellular Traction Stresses Increase with Increasing Metastatic Potential

(2012) Casey M. Kraning-Rush et al.   PLoS One

Insights into the Role of Focal Adhesion Modulation in Myogenic Differentiation of Human Mesenchymal Stem Cells

(2012) Haiyang Yu et al.   STEM CELLS AND DEVELOPMENT

Modulating the Rigidity and Mineralization of Collagen Gels Using Poly(Lactic-Co-Glycolic Acid) Microparticles

(2012) Ross J. DeVolder et al.   TISSUE ENGINEERING PART A

Controlling matrix stiffness and topography for the study of tumor cell migration

(2012) Casey M. Kraning-Rush et al.   Cell Adhesion & Migration

High Resolution Genome Wide Binding Event Finding and Motif Discovery Reveals Transcription Factor Spatial Binding Constraints

(2012) Yuchun Guo et al.   PLoS Computational Biology

Screening of rat mesenchymal stem cell behaviour on polydimethylsiloxane stiffness gradients

(2011) Peng-Yuan Wang et al.   Acta Biomaterialia

The influence of elasticity and surface roughness on myogenic and osteogenic-differentiation of cells on silk-elastin biomaterials

(2011) Xiao Hu et al.   BIOMATERIALS

The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β

(2011) Jennifer S. Park et al.   BIOMATERIALS

Mechanobiology of tumor invasion: Engineering meets oncology

(2011) Shawn P. Carey et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Localized bimodal response of neurite extensions and structural proteins in dorsal-root ganglion neurons with controlled polydimethylsiloxane substrate stiffness

(2011) Chao-Min Cheng et al.   JOURNAL OF BIOMECHANICS

Modulus- and surface energy-tunable ultraviolet-curable polyurethane acrylate: properties and applications

(2011) Se-Jin Choi et al.   JOURNAL OF MATERIALS CHEMISTRY

Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity

(2011) Michael T Yang et al.   Nature Protocols

Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity

(2011) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration

(2011) J. Huynh et al.   Science Translational Medicine

Linking Microscopic Spatial Patterns of Tissue Destruction in Emphysema to Macroscopic Decline in Stiffness Using a 3D Computational Model

(2011) Harikrishnan Parameswaran et al.   PLoS Computational Biology

The dependence of MG63 osteoblast responses to (meth)acrylate-based networks on chemical structure and stiffness

(2010) Kathryn E. Smith et al.   BIOMATERIALS

The role of stiffness of gelatin–hydroxyphenylpropionic acid hydrogels formed by enzyme-mediated crosslinking on the differentiation of human mesenchymal stem cell

(2010) Li-Shan Wang et al.   BIOMATERIALS

Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells

(2010) Yu-Ru V Shih et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Designed biomaterials to mimic the mechanical properties of muscles

(2010) Shanshan Lv et al.   NATURE

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

Soft poly(n-butyl acrylate) networks with tailored mechanical properties designed as substrates for in vitro models

(2010) J. Cui et al.   POLYMERS FOR ADVANCED TECHNOLOGIES

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis, characterization and surface modification of low moduli poly(ether carbonate urethane)ureas for soft tissue engineering

(2009) Feng Wang et al.   Acta Biomaterialia

The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells

(2009) Akhilesh Banerjee et al.   BIOMATERIALS

The effect of matrix stiffness on mesenchymal stem cell differentiation in a 3D thixotropic gel

(2009) Y. Shona Pek et al.   BIOMATERIALS

Injectable biodegradable hydrogels with tunable mechanical properties for the stimulation of neurogenesic differentiation of human mesenchymal stem cells in 3D culture

(2009) Li-Shan Wang et al.   BIOMATERIALS

Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells

(2009) Evelyn K.F. Yim et al.   BIOMATERIALS

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

(2009) Farshid Guilak et al.   Cell Stem Cell

Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening

(2009) Eric A. Klein et al.   CURRENT BIOLOGY

Spatial patterning of cell proliferation and differentiation depends on mechanical stress magnitude

(2009) Bin Li et al.   JOURNAL OF BIOMECHANICS

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Spatially controlled hydrogel mechanics to modulate stem cell interactions

(2009) Ross A. Marklein et al.   Soft Matter

Effect of Matrix Elasticity on the Maintenance of the Chondrogenic Phenotype

(2009) Elena Schuh et al.   TISSUE ENGINEERING PART A

Polyelectrolyte Multilayer Films of Controlled Stiffness Modulate Myoblast Cell Differentiation

(2008) Kefeng Ren et al.   ADVANCED FUNCTIONAL MATERIALS

Substrate Modulus Directs Neural Stem Cell Behavior

(2008) Krishanu Saha et al.   BIOPHYSICAL JOURNAL

A Balance of Substrate Mechanics and Matrix Chemistry Regulates Endothelial Cell Network Assembly

(2008) Joseph P. Califano et al.   Cellular and Molecular Bioengineering

Extracellular Matrix Rigidity Promotes Invadopodia Activity

(2008) Nelson R. Alexander et al.   CURRENT BIOLOGY

The role of matrix stiffness in regulating cell behavior

(2008) Rebecca G. Wells   HEPATOLOGY

Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner

(2008) H. Hirata et al.   JOURNAL OF CELL SCIENCE

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effect of Scaffold Stiffness on Myoblast Differentiation

(2008) Meital Levy-Mishali et al.   TISSUE ENGINEERING PART A

Surface ultrastructure and mechanical property of human chondrocyte revealed by atomic force microscopy

(2007) C.-H. Hsieh et al.   OSTEOARTHRITIS AND CARTILAGE