Article
Polymer Science
Maria Herrero-Herrero, Jose Antonio Gomez-Tejedor, Ana Valles-Lluch
Summary: Tailored membranes with a fiber diameter of 1.8 μm were electrospun from PLGA and PCLGA solutions by adjusting electrospinning and polymer solution parameters. PCLGA, with its amorphous morphology, required the addition of a salt to increase conductivity for successful electrospinning, presenting notable difficulties due to its structure. Interestingly, PCLGA, with a higher glycolic acid molar fraction, could be successfully electrospun, a feat not previously reported.
Article
Engineering, Biomedical
Pranav P. Kalelkar, Dina A. Moustafa, Milan Riddick, Joanna B. Goldberg, Nael A. McCarty, Andres J. Garcia
Summary: This study demonstrates that porous microparticles engineered from poly(lactic-co-glycolic acid) (PLGA) can effectively deliver phage to the lung, showing potent antimicrobial efficacy against Gram-positive Staphylococcus aureus in vitro and in vivo, and arresting the growth of S. aureus in the presence of Pseudomonas aeruginosa. The phage-loaded microparticles also exhibit excellent cytocompatibility with human lung epithelial cells.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Polymer Science
Federico Karp, Florencia S. Satler, Carlos A. Busatto, Julio A. Luna, Diana A. Estenoz, Ludmila N. Turino
Summary: The present work aimed to characterize PLGA microparticles, including biopolymers, for controlled release of the broad-spectrum antibiotic tilmicosin. Microparticles were prepared using the double-emulsion solvent evaporation technique, and the influence of alginate and pectin incorporation on particle properties was evaluated. The combination of PLGA and biopolymers strongly affected the morphology of the particles and drug release profiles.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jeong Eun Song, Dae Hoon Lee, Gilson Khang, Sun-Jung Yoon
Summary: Collagen, with its low antigenicity and excellent cell adhesion properties, is widely used as a biomaterial for bone, cartilage, and skin regeneration. A study showed that a scaffold mixed with duck feet-derived collagen and Poly(lactic-co-glycolic acid) reduced inflammation and improved bone regeneration. By including hydroxyapatite, a key osteoconductive material, in the scaffold, we found that increasing the concentration of duck feet-derived collagen not only improved its strength, but also enhanced cell proliferation and osteogenic differentiation. Furthermore, the addition of hydroxyapatite promoted osteogenic differentiation. The study demonstrated that the 80 wt% duck feet-derived collagen/Poly(lactic-co-glycolic acid)/hydroxyapatite scaffold promotes bone mineralization and collagen deposition while reducing inflammation, making it an excellent biomaterial for bone regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Engineering, Biomedical
Duoyi Zhao, Tongtong Zhu, Jie Li, Liguo Cui, Zhiyu Zhang, Xiuli Zhuang, Jianxun Ding
Summary: This article comprehensively reviews the research and applications of artificial bone-substitute materials based on PLGA and its composites, discussing their potential and challenges in bone regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Rong Wang, Xiaojie Sun, Lanlan Chen, Wenbin Liang
Summary: In this study, biodegradable blends of PGA and PBAT with in situ compatibilization using MDI were prepared. The addition of PBAT was found to increase the complex viscosity and storage modulus of the blends, leading to improved compatibility and impact strength. The morphology of the dispersed phase evolved from spherical structure to in situ microfiber, enhancing interfacial adhesion and improving toughness.
Article
Pharmacology & Pharmacy
Seung-No Hong, Minjae Kim, Jin-A Park, Minji Kang, Hyunkyung Cha, Sohyun Park, Joon Kon Kim, Jinyoung Pac, Yuju Seo, Sungwhan Kim, Minju Kim, Dae Woo Kim, Yan Lee
Summary: This study designed dexamethasone-loaded poly(lactic-co-glycolic acid) microparticles with bone-specific binding affinity for the treatment of sinus surgery-induced osteitis in chronic rhinosinusitis (CRS). The microparticles released the encapsulated dexamethasone in a sustained manner on the exposed bone after the surgical wound in the nasal cavity. The results showed that the microparticles had higher binding affinity and inhibited the formation of undesirable new woven bone. Therefore, this localized corticoid delivery method has the potential to treat CRS-related osteitis with minimal side effects.
Article
Engineering, Biomedical
Aklima Nasrin, Mahbub Hassan, Maria Montero Mirabet, Norbert Windhab, Vincent G. Gomes
Summary: Multifunctional 3D-printed nanocomposites based on PLGA were developed for bone tissue engineering, with CQDs enhancing cell biocompatibility, promoting cellular nesting, and improving osteogenesis.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Materials Science, Multidisciplinary
Eva M. M. Eger, Seema Agarwal
Summary: This study focuses on the characterization and reprocessing ability of PLGA in the form of dynamic covalent networks. The synthesized networks with dynamic bonding and debonding have enhanced thermomechanical properties and maintain the potential for thermal reprocessing and recycling like thermoplastics.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is widely used in various biomedical applications due to its biodegradability and biocompatibility. This study successfully developed a method to synthesize syndioenriched, alternating PLGA from racemic methyl-glycolide (rac-MeG), and confirmed the high degree of alternation of the comonomer sequence and moderate syndiotacticity within the polymer backbone stereoconfiguration through NMR investigations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable and biocompatible polymer used in biomedical applications. This study presents a method for synthesizing syndioenriched, alternating PLGA from racemic methyl-glycolide with the use of an optimized racemic aluminum catalyst. The resulting material has a high degree of alternation in copolymer sequence and moderate syndiotacticity, and is amorphous, making it suitable for drug complexation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Polymer Science
Alastair Little, Alan M. Wemyss, David M. Haddleton, Bowen Tan, Zhaoyang Sun, Yang Ji, Chaoying Wan
Summary: The study investigates the effects of various reaction conditions on the synthesis of PLGA25, showing how factors such as reaction temperature, initiator concentration, and catalyst concentration impact the molecular weight, monomer conversion, and thermal properties.
Article
Pharmacology & Pharmacy
Wan-Yi Liu, Yun-Shan Hsieh, Yu-Tse Wu
Summary: This study aimed to develop a nanoparticle formulation for the oral delivery of beta-carotene. The results showed that the formulation significantly enhanced the release and intestinal permeability of the drug, suggesting its potential for oral administration.
Article
Materials Science, Multidisciplinary
Ying Mao, Robert Guidoin, Yan Li, Gaetan Brochu, Ze Zhang, Lu Wang
Summary: Blending L-alpha-phosphatidylcholine (PC) with PLGA to yield hybrid scaffolds alters the physical properties and wettability, affecting biodegradability and biocompatibility. The addition of PC decreases fiber diameter and increases porosity and hydrophilicity, although it also reduces mechanical strength of the scaffolds.
MATERIALS & DESIGN
(2021)
Article
Biochemistry & Molecular Biology
Seounghun Lee, Hyo-Jung Shin, Chan Noh, Song- Kim, Young-Kwon Ko, Sun-Yeul Lee, Chaeseong Lim, Boohwi Hong, Sin-Young Yang, Dong-Woon Kim, Won-Hyung Lee, Yoon-Hee Kim
Summary: The activation of NF-kappa B in microglia is crucial for the development of neuropathic pain. Inhibitor of I kappa B (I kappa B) blocks NF-kappa B activation, and IKBKB is responsible for breaking down I kappa B to inhibit NF-kappa B activity. Delivering IKBKB siRNA via PLGA nanoparticles effectively reduces pain response and inflammatory mediators in SNL rats, suggesting its potential as a treatment for neuropathic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)