The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes

Regulation of Posttranslational Modifications of HMGB1 During Immune Responses

(2016) Yiting Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

Ketamine attenuates sepsis-induced acute lung injury via regulation of HMGB1-RAGE pathways

(2016) Kehan Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Therapeutic potential of the dual peroxisome proliferator activated receptor (PPAR)α/γ agonist aleglitazar in attenuating TNF-α-mediated inflammation and insulin resistance in human adipocytes

(2016) Marika Massaro et al.   PHARMACOLOGICAL RESEARCH

Blocking Nuclear Factor-Kappa B Protects against Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice

(2016) Tianshu Zeng et al.   PLoS One

MD-2 is required for disulfide HMGB1–dependent TLR4 signaling

(2015) Huan Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HMGB1-Mediated Early Loss of Transplanted Islets Is Prevented by Anti–IL-6R Antibody in Mice

(2015) Takeshi Itoh et al.   PANCREAS

HMGB1–RAGE signaling pathway in severe preeclampsia

(2015) Linlin Zhu et al.   PLACENTA

Plasma HMGB-1 Levels in Subjects with Obesity and Type 2 Diabetes: A Cross-Sectional Study in China

(2015) Hang Wang et al.   PLoS One

DAMP production by human islets under low oxygen and nutrients in the presence or absence of an immunoisolating-capsule and necrostatin-1

(2015) Genaro A. Paredes-Juarez et al.   Scientific Reports

Anti-HMGB1 antibody reduces weight gain in mice fed a high-fat diet

(2015) V N Montes et al.   Nutrition & Diabetes

Circulating pathogen associated molecular pattern – Binding proteins and High Mobility Group Box protein 1 in nascent metabolic syndrome: Implications for cellular Toll-like receptor activity

(2014) I. Jialal et al.   ATHEROSCLEROSIS

RAGE Regulates the Metabolic and Inflammatory Response to High-Fat Feeding in Mice

(2014) Fei Song et al.   DIABETES

Macrophages, Immunity, and Metabolic Disease

(2014) Joanne C. McNelis et al.   IMMUNITY

Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes

(2014) Clara Westwell-Roper et al.   IMMUNOLOGY AND CELL BIOLOGY

High hydrostatic pressure induces immunogenic cell death in human tumor cells

(2014) Jitka Fucikova et al.   INTERNATIONAL JOURNAL OF CANCER

Alarmin high-mobility group B1 (HMGB1) is regulated in human adipocytes in insulin resistance and influences insulin secretion in β-cells

(2014) R Guzmán-Ruiz et al.   INTERNATIONAL JOURNAL OF OBESITY

Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation

(2014) Md Ashik Ullah et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-  Production in Human Monocytes

(2014) J. H. Youn et al.   JOURNAL OF IMMUNOLOGY

HMGB1 in health and disease

(2014) Rui Kang et al.   MOLECULAR ASPECTS OF MEDICINE

Metformin protects against hyperglycemia-induced cardiomyocytes injury by inhibiting the expressions of receptor for advanced glycation end products and high mobility group box 1 protein

(2014) Ting Zhang et al.   MOLECULAR BIOLOGY REPORTS

High Concentration of Insulin Promotes Apoptosis of Primary Cultured Rat Ovarian Granulosa Cells Via Its Increase in Extracellular HMGB1

(2014) Xiao-Rong Ni et al.   Reproductive Sciences

Pretreatment of Donor Islets With the Na+/Ca2+Exchanger Inhibitor Improves the Efficiency of Islet Transplantation

(2013) T. Mera et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance

(2013) Byung-Cheol Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Involvement of HMGB1 mediated signalling pathway in diabetic retinopathy: evidence from type 2 diabetic rats and ARPE-19 cells under diabetic condition

(2013) Xiao-Li Chen et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Evation of High-Mobility Group Box 1 after Clinical Autologous Islet Transplantation and Its Inverse Correlation with Outcomes

(2013) Takeshi Itoh et al.   CELL TRANSPLANTATION

High-mobility group protein B1: a new biomarker of metabolic syndrome in obese children

(2013) Teresa Arrigo et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Chaperone-like Activity of High-Mobility Group Box 1 Protein and Its Role in Reducing the Formation of Polyglutamine Aggregates

(2013) H. J. Min et al.   JOURNAL OF IMMUNOLOGY

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

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(2013) Sodam Kim et al.   MOLECULAR MEDICINE

Efficacy of DHMEQ, a NF-κB Inhibitor, in Islet Transplantation

(2013) Daisuke Kuraya et al.   TRANSPLANTATION

Unlocking the biology of RAGE in diabetic microvascular complications

(2013) Michaele B. Manigrasso et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mechanisms of Obesity-Induced Inflammation and Insulin Resistance: Insights into the Emerging Role of Nutritional Strategies

(2013) Maeve A. McArdle et al.   Frontiers in Endocrinology

Role and function of macrophages in the metabolic syndrome

(2012) Prerna Bhargava et al.   BIOCHEMICAL JOURNAL

H1 and HMGB1: modulators of chromatin structure

(2012) Jean O. Thomas et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma

(2012) Juan Wu et al.   CANCER RESEARCH

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

Relationship of Soluble RAGE and RAGE Ligands HMGB1 and EN-RAGE to Endothelial Dysfunction in Type 1 and Type 2 Diabetes Mellitus

(2012) J. Škrha Jr et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Toll-like receptor 4 on islet β cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes

(2012) Min Li et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

NF-κB regulation: lessons from structures

(2012) Gourisankar Ghosh et al.   IMMUNOLOGICAL REVIEWS

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The IKK -Dependent NF- B p52/RelB Noncanonical Pathway Is Essential To Sustain a CXCL12 Autocrine Loop in Cells Migrating in Response to HMGB1

(2012) R. R. Kew et al.   JOURNAL OF IMMUNOLOGY

Fatty acids do not pay the toll: effect of SFA and PUFA on human adipose tissue and mature adipocytes inflammation

(2012) Ravi Kumar Murumalla et al.   Lipids in Health and Disease

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(2012) Huan Yang et al.   MOLECULAR MEDICINE

Rage signalling promotes intestinal tumourigenesis

(2012) J Heijmans et al.   ONCOGENE

Inhibitory effects of ethyl pyruvate administration on human gastric cancer growth via regulation of the HMGB1-RAGE and Akt pathways in vitro and in vivo

(2012) Jin-Shui Zhu   ONCOLOGY REPORTS

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

High Mobility Group Box 1 (HMGB1) Activates an Autophagic Response to Oxidative Stress

(2011) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice

(2011) Xavier Prieur et al.   DIABETES

Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model

(2011) Ju Ho Youn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HMGB1, TLR and RAGE: a functional tripod that leads to diabetic inflammation

(2011) José Augusto Nogueira-Machado et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

TLR4 Mediates Early Graft Failure After Intraportal Islet Transplantation

(2010) Q. Gao et al.   AMERICAN JOURNAL OF TRANSPLANTATION

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

High-Mobility Group Box Protein 1 Neutralization Reduces Development of Diet-Induced Atherosclerosis in Apolipoprotein E–Deficient Mice

(2010) Peter Kanellakis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High-mobility group box 1 and cancer

(2010) Daolin Tang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

HMGB proteins: Interactions with DNA and chromatin

(2010) Michal Štros   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

HMGB1: Roles in base excision repair and related function

(2010) Yuan Liu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice

(2010) Konstantin Tsoyi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Insulin Suppresses Endotoxin-Induced Oxidative, Nitrosative, and Inflammatory Stress in Humans

(2010) P. Dandona et al.   DIABETES CARE

Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects

(2010) M. R. Dasu et al.   DIABETES CARE

High-mobility group box 1 exacerbates concanavalin A-induced hepatic injury in mice

(2010) Quan Gong et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival

(2009) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model*

(2009) Satoshi Hagiwara et al.   CRITICAL CARE MEDICINE

Islet-associated macrophages in type 2 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

(2009) Marianne Böni-Schnetzler et al.   ENDOCRINOLOGY

In VitroHyperresponsiveness to Tumor Necrosis Factor-α Contributes to Adipokine Dysregulation in Omental Adipocytes of Obese Subjects

(2009) Eléonore Maury et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipose tissue as an endocrine organ

(2009) Sandra Galic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

(2009) J. A. Ehses et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1)

(2008) Judy R. van Beijnum et al.   ANGIOGENESIS

Extracellular High-Mobility Group Box 1 Acts as an Innate Immune Mediator to Enhance Autoimmune Progression and Diabetes Onset in NOD Mice

(2008) J. Han et al.   DIABETES

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

(2008) C. N. Lumeng et al.   DIABETES

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unknown

(2008) John Klune et al.   MOLECULAR MEDICINE

Protective Effect of Antagonist of High-mobility Group Box 1 on Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2008) Q. Gong et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY