Potential Antifungal Targets against a Candida Biofilm Based on an Enzyme in the Arachidonic Acid Cascade—A Review

Identification of novel membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitors with anti-influenza activities in vitro

(2016) Ji Hoon Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vitro interactions between anidulafungin and nonsteroidal anti-inflammatory drugs on biofilms of Candida spp.

(2016) Antonio Rosato et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Prostaglandins from Cytosolic Phospholipase A2α/Cyclooxygenase-1 Pathway and Mitogen-activated Protein Kinases Regulate Gene Expression inCandida albicans-infected Macrophages

(2016) Bogeon Yun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Candida albicans and Pseudomonas aeruginosa Interaction, with Focus on the Role of Eicosanoids

(2016) Ruan Fourie et al.   Frontiers in Physiology

In Vitro Interactions between Non-Steroidal Anti-Inflammatory Drugs and Antifungal Agents against Planktonic and Biofilm Forms of Trichosporon asahii

(2016) Suteng Yang et al.   PLoS One

Candida albicansBiofilms and Human Disease

(2015) Clarissa J. Nobile et al.   Annual Review of Microbiology

Ibuprofen Potentiates theIn VivoAntifungal Activity of Fluconazole against Candida albicans Murine Infection

(2015) Sofia Costa-de-Oliveira et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Potential Targets for Antifungal Drug Discovery Based on Growth and Virulence in Candida albicans

(2015) Xiuyun Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Morphology-Independent Virulence of Candida Species during Polymicrobial Intra-abdominal Infections with Staphylococcus aureus

(2015) Evelyn E. Nash et al.   INFECTION AND IMMUNITY

Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats

(2015) Mushfiquddin Khan et al.   Journal of Neuroinflammation

A COX/5-LOX Inhibitor Licofelone Revealed Anticonvulsant Properties Through iNOS Diminution in Mice

(2015) Borna Payandemehr et al.   NEUROCHEMICAL RESEARCH

A combination approach to treating fungal infections

(2015) Sanjib K. Shrestha et al.   Scientific Reports

Candida parapsilosisproduces prostaglandins from exogenous arachidonic acid andOLE2is not required for their synthesis

(2015) Zsuzsanna Grózer et al.   Virulence

Hypoxia and Temperature Regulated Morphogenesis in Candida albicans

(2015) Prashant R. Desai et al.   PLoS Genetics

Treatment with some anti-inflammatory drugs reduces germ tube formation in Candida albicans strains

(2015) Elena Rusu et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Prostaglandin E2 from Candida albicans Stimulates the Growth of Staphylococcus aureus in Mixed Biofilms

(2015) Jan Krause et al.   PLoS One

Cytosolic phospholipase A2α enhances mouse mortality induced by Pseudomonas aeruginosa pulmonary infection via interleukin 6

(2014) Laurent Guillemot et al.   BIOCHIMIE

Arachidonic acid affects biofilm formation and PGE2 level in Candida albicans and non-albicans species in presence of subinhibitory concentration of fluconazole and terbinafine

(2014) Nripendra Nath Mishra et al.   Brazilian Journal of Infectious Diseases

Combination of fluconazole with non-antifungal agents: A promising approach to cope with resistant Candida albicans infections and insight into new antifungal agent discovery

(2014) Shuyuan Liu et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

A Cyclooxygenase-2-dependent Prostaglandin E2Biosynthetic System in the Golgi Apparatus

(2014) Chong Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Microsomal Prostaglandin E Synthase 1 Inhibitors

(2013) Marina Korotkova et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Inhibitors of the Arachidonic Acid Cascade: Interfering with Multiple Pathways

(2013) Karin Meirer et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Synergistic Regulation of Hyphal Elongation by Hypoxia, CO2, and Nutrient Conditions Controls the Virulence of Candida albicans

(2013) Yang Lu et al.   Cell Host & Microbe

Dysregulated Heme Oxygenase–Ferritin System in Pterygium Pathogenesis

(2013) Timothy Fox et al.   CORNEA

In vitro analysis of flufenamic acid activity against Candida albicans biofilms

(2013) Alba A. Chavez-Dozal et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Cyclooxygenase inhibitors reduce biofilm formation and yeast-hypha conversion of fluconazole resistant Candida albicans

(2013) E. Abdelmegeed et al.   JOURNAL OF MICROBIOLOGY

In VitroInteractions between Aspirin and Amphotericin B against Planktonic Cells and Biofilm Cells of Candida albicans and C. parapsilosis

(2012) Yabin Zhou et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial-Resistant Pathogens Associated with Healthcare-Associated Infections Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009–2010

(2012) Dawn M. Sievert et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

The Nonsteroidal Antiinflammatory Drug Diclofenac Potentiates the In Vivo Activity of Caspofungin Against Candida albicans Biofilms

(2012) Anna Bink et al.   JOURNAL OF INFECTIOUS DISEASES

Dynamic eicosanoid responses upon different inhibitor and combination treatments on the arachidonic acid metabolic network

(2012) Chong He et al.   Molecular BioSystems

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

(2011) Edward A. Dennis et al.   CHEMICAL REVIEWS

Antifungal activity of some cyclooxygenase inhibitors on Candida albicans: PGE2-dependent mechanism

(2011) Andreza Urba de Quadros et al.   FOLIA MICROBIOLOGICA

Leukotrienes Target F-actin/Cofilin-1 to Enhance Alveolar Macrophage Anti-fungal Activity

(2011) Mariana Morato-Marques et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sciadonic acid modulates prostaglandin E2 production by epithelial cells during infection with C. albicans and C. dubliniensis

(2011) Ruan Ells et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo

(2010) Julia Bauer et al.   BIOCHEMICAL PHARMACOLOGY

The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages

(2010) A Rossi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pathways Regulating Cytosolic Phospholipase A2Activation and Eicosanoid Production in Macrophages byCandida albicans

(2010) Saritha Suram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer

(2010) O. Rådmark et al.   JOURNAL OF INTERNAL MEDICINE

Effect of inhibitors of arachidonic acid metabolism on prostaglandin E2 production by Candida albicans and Candida dubliniensis biofilms

(2010) Ruan Ells et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Cytosolic Phospholipase A2Activation byCandida albicansin Alveolar Macrophages

(2009) Rajinder P. Parti et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E2 synthase-1

(2009) A Koeberle et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prostaglandin E2synthase inhibition as a therapeutic target

(2009) Jitesh P Iyer et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Ibuprofen reverts antifungal resistance onCandida albicansshowing overexpression of CDR genes

(2009) Elisabete Ricardo et al.   FEMS YEAST RESEARCH

The Molecular Pharmacology and In Vivo Activity of 2-(4-Chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a Dual Inhibitor of Microsomal Prostaglandin E2 Synthase-1 and 5-Lipoxygenase

(2009) A. Koeberle et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The role of diclofenac sodium in the dimorphic transition in Candida albicans

(2009) Zahra Rashki Ghalehnoo et al.   MICROBIAL PATHOGENESIS

Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1

(2009) A. Koeberle et al.   MOLECULAR CANCER THERAPEUTICS

Arachidonic acid cytochrome P450 epoxygenase pathway

(2008) Arthur A. Spector   JOURNAL OF LIPID RESEARCH

Pharmacological and Clinical Aspects of Heme Oxygenase

(2008) N. G. Abraham et al.   PHARMACOLOGICAL REVIEWS