Characterization of Microsomal Prostaglandin E Synthase 1 Inhibitors

Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model

(2013) Yoshiharu Akitake et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily

(2013) T. Sjogren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a new mPGES-1 inhibitor in rat models of inflammation

(2013) Patrick Leclerc et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation

(2012) Graciela B. Arhancet et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pharmacological Inhibition of Microsomal Prostaglandin E Synthase-1 Suppresses Epidermal Growth Factor Receptor-Mediated Tumor Growth and Angiogenesis

(2012) Federica Finetti et al.   PLoS One

Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue

(2012) Karina Gheorghe et al.   ARTHRITIS RESEARCH & THERAPY

Expression of Prostaglandin E Synthases in Periodontitis

(2011) Tove Båge et al.   AMERICAN JOURNAL OF PATHOLOGY

Microsomal Prostaglandin E 2 Synthase-1 Modulates the Response to Vascular Injury

(2011) Miao Wang et al.   CIRCULATION

Identification and development of mPGES-1 inhibitors: where we are at?

(2011) Hui-Hua Chang et al.   Future Medicinal Chemistry

Prostaglandin E2 Synthesizing Enzymes in Rheumatoid Arthritis B Cells and the Effects of B Cell Depleting Therapy on Enzyme Expression

(2011) Karina Roxana Gheorghe et al.   PLoS One

Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E2 Synthase-1 and Suppresses Prostaglandin E2 Formation in vivo

(2011) Andreas Koeberle et al.   Frontiers in Pharmacology

Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor

(2010) Gabriel Mbalaviele et al.   BIOCHEMICAL PHARMACOLOGY

mPGES-1 as a target for cancer suppression

(2010) Masako Nakanishi et al.   BIOCHIMIE

Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity

(2010) Y Ikeda-Matsuo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1

(2010) Sven-Christian Pawelzik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Periodontitis in RA—the citrullinated enolase connection

(2010) Karin Lundberg et al.   Nature Reviews Rheumatology

Common structural features of mapeg-a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

(2010) Per-Johan Jakobsson et al.   PROTEIN SCIENCE

Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E 2 synthase-1

(2009) Andreas Koeberle et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis

(2009) Daisuke Kamei et al.   BIOCHEMICAL JOURNAL

Effects of AF3442 [ N -(9-ethyl-9 H -carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro

(2009) Annalisa Bruno et al.   BIOCHEMICAL PHARMACOLOGY

Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E2 synthase-1

(2009) A Koeberle et al.   BRITISH JOURNAL OF PHARMACOLOGY

Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1

(2009) A. Koeberle et al.   MOLECULAR CANCER THERAPEUTICS

Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells

(2009) H. Hanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis

(2009) Y. Kihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of microsomal prostaglandin E synthase-1 deletion and COX-2 inhibition in acute cardiac ischemia in mice

(2009) Dongmei Wu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Prostaglandin E2 synthases in neurologic homeostasis and disease

(2009) M. Kerry O’Banion   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Microsomal prostaglandin E synthase protein levels correlate with prognosis in colorectal cancer patients

(2009) Tsuguhiko Seo et al.   VIRCHOWS ARCHIV

Dimethylcelecoxib inhibits prostaglandin E2 production

(2008) Ivonne Wobst et al.   BIOCHEMICAL PHARMACOLOGY

Genetic Deletion of mPGES-1 Suppresses Intestinal Tumorigenesis

(2008) M. Nakanishi et al.   CANCER RESEARCH

Microsomal Prostaglandin E 2 Synthase-1 Deletion Leads to Adverse Left Ventricular Remodeling After Myocardial Infarction

(2008) Norbert Degousee et al.   CIRCULATION

Pirinixic Acid Derivatives as Novel Dual Inhibitors of Microsomal Prostaglandin E2Synthase-1 and 5-Lipoxygenase

(2008) Andreas Koeberle et al.   JOURNAL OF MEDICINAL CHEMISTRY

MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation

(2008) D. Xu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

(2008) A. Koeberle et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structural basis for induced formation of the inflammatory mediator prostaglandin E2

(2008) C. Jegerschold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated microsomal prostaglandin-E synthase–1 in Alzheimer’s disease

(2007) Uzma A. Chaudhry et al.   Alzheimers & Dementia