Article
Chemistry, Applied
Xin Zhang, Lin Chen, Ying-Ying Wei, Jing-Lei Du, Shi-Ping Yu, Xu-Guang Liu, Wei Liu, Yan-Jun Liu, Yong-Zhen Yang, Qiang Li
Summary: A fluorescence probe called GTCDs was developed for efficient imaging monitoring of Golgi apparatus. It targets the Golgi apparatus by forming hydrogen bonds with COX-2 on its surface, allowing for accurate visualization of Golgi apparatus' status.
Article
Chemistry, Physical
Chenqi Guo, Xiong Peng, Ting Zhao, Jiaxing Feng, Zhaofei Guo, Mengying Wu, Rongping Zhang, Xun Sun, Yuan Huang, Zhirong Zhang, Tao Gong
Summary: Combination therapy mediated by nanomedicine delivery strategy, specifically using cyclooxygenase-2 (COX-2) inhibitors and Golgi disrupting agents, shows promise in treating breast cancer and metastasis by improving therapeutic efficacy and inhibiting tumor growth and progression.
Article
Biochemistry & Molecular Biology
Piotr Wojcik, Michal Biernacki, Natalia Domian, Neven Zarkovic, Elzbieta Skrzydlewska
Summary: This study evaluated the impact of Celecoxib on apoptosis in keratinocytes, and the results suggested that COX-2 inhibition can attenuate UVB-induced apoptosis, with AEA playing a significant role as an anti-apoptotic agent in this process.
Article
Immunology
Nitin Kamble, Angila Gurung, Benedikt B. Kaufer, Ansar Ahmed Pathan, Shahriar Behboudi
Summary: MDV infection induces activation of COX-2 and production of PGE2, leading to inhibition of T cell proliferation via EP2 and EP4 receptors on day 21 post infection. Oral administration of the COX-2 inhibitor meloxicam during MDV infection suppresses COX-2 activation and rescues T cell proliferation on day 21 post infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Filippo Pelizzaro, Maria Piera Kitenge, Romilda Cardin, Alberto Ponzoni, Umberto Cillo, Alessandro Vitale, Gianluca Businello, Giada Munari, Matteo Fassan, Fabio Farinati
Summary: The study revealed the activation of the MAGL/COX-2/PGE2 axis in hepatocellular carcinoma, with circulating PGE2 serving as a potential prognostic biomarker in HCC patients. Elevated levels of circulating PGE2 were associated with significantly shorter overall survival in HCC patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Hematology
Robert Eckenstaler, Anne Ripperger, Michael Hauke, Markus Petermann, Sandra A. Hemkemeyer, Edzard Schwedhelm, Sueleyman Erguen, Maike Frye, Oliver Werz, Andreas Koeberle, Heike Braun, Ralf A. Benndorf
Summary: This study reveals the direct link between upregulation of TP expression and angiostatic TP signaling in endothelial cells, leading to endothelial dysfunction, microvascular rarefaction, and systemic hypertension.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Corey S. Moran, Erik Biros, Smriti M. Krishna, Susan K. Morton, Daniel J. Sexton, Jonathan Golledge
Summary: The study showed that neutralization of kallikrein-1 with blocking antibody inhibited AAA development in a mouse model, reduced inflammation, and decreased levels of related proteins and metabolites.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Urology & Nephrology
Yu Pan, Shirong Cao, Andrew S. Terker, Jiaqi Tang, Kensuke Sasaki, Yinqiu Wang, Aolei Niu, Wentian Luo, Xiaofeng Fan, Suwan Wang, Matthew H. Wilson, Ming-Zhi Zhang, Raymond C. Harris
Summary: Macrophages play a critical role in the recovery of kidney injury. The increased expression of cyclooxygenase 2 (COX-2) in macrophages following injury is important for recovery. Activation of the prostaglandin E2 (PGE2) receptor EP4 induces the expression of anti-inflammatory genes and suppresses pro-inflammatory genes in kidney macrophages. These findings provide new insights into the mechanisms underlying the negative effects of non-steroidal anti-inflammatory drugs that inhibit cyclooxygenase activity on the kidneys.
KIDNEY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Alexander Hedbrant, Ingrid Persson, Ann Erlandsson, Jonny Wijkander
Summary: Green and black tea, and to a lesser extent Rooibos tea, are able to inhibit the formation of PGE2 in human monocytes and mediate their effects by inhibiting the expression of the enzymes responsible for PGE2 formation.
Article
Chemistry, Multidisciplinary
Zhi-Chao Hu, Ben Wang, Xiao-Gang Zhou, Hai-Feng Liang, Bing Liang, Hong-Wei Lu, Yu-Xiang Ge, Qing Chen, Qi-Wei Tian, Feng-Feng Xue, Li-Bo Jiang, Jian Dong
Summary: This study developed a Golgi apparatus-targeted photodynamic strategy to activate NLRP3 and found that it promoted the release of proinflammatory contents, enhancing innate immunity and tumor immunogenicity. Pyroptosis led to immunogenic cell death, promoted dendritic cell maturation, and effectively activated antitumor immunity and long-lived immune memory.
Review
Urology & Nephrology
Henricus A. M. Mutsaers, Rikke Norregaard
Summary: This article summarizes the role of PGE2 in the kidney and focuses on the involvement of the four EP receptors in renal fibrosis.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Anders Blomqvist
Summary: We have recently shown that prostaglandin production in brain endothelial cells is essential for fever generation during systemic immune challenge. In this discussion, I examine the implications of this finding in relation to previous studies and highlight unresolved issues.
DNA AND CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Haiyan Yao, Quanping Guo, Mengran Wang, Rui Wang, Zhaoqing Xu
Summary: A novel class of molecules with a basic structure of pyrazole N-aryl sulfonate was designed and synthesized using a new pyrazole sulfonate synthetic method. Several compounds within this class showed excellent anti-inflammatory and analgesic activities, as well as selective COX-2 inhibitory properties. The LD50 of two compounds in mice were found to be greater than 2000 mg/kg in acute oral toxicity assays conducted in vivo.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Kunshan Huang, Han Zhang, Meiqi Yan, Jinping Xue, Juanjuan Chen
Summary: Introducing indomethacin to conjugate with zinc phthalocyanines successfully addresses the issues of photosensitizer aggregation, poor tumor targeting, and limited action radius of reactive oxygen species. The designed photosensitizer IMC-Pc shows improved efficiency in intracellular reactive oxygen species generation and anticancer efficacy through cyclooxygenase-2-driven dual targeting and aggregation inhibition.
Article
Immunology
Wenfei Wang, Yuping Ning, Yejun Wang, Guofang Deng, Simona Pace, Stefanie A. Barth, Christian Menge, Kehong Zhang, Youchao Dai, Yi Cai, Xinchun Chen, Oliver Werz
Summary: This study found that infection of human macrophages by M.tb significantly increases the expression of COX-2 and mPGES-1, leading to the formation of a large amount of PGE(2). However, the anti-inflammatory drug SASP can reduce the expression of COX-2 and the release of PGE(2).
FRONTIERS IN IMMUNOLOGY
(2022)