First Line of Defense: Innate Cell-Mediated Control of Pulmonary Aspergillosis

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

CD103+ Dendritic Cells Control Th17 Cell Function in the Lung

(2015) Teresa Zelante et al.   Cell Reports

Recognition of Aspergillus fumigatus Hyphae by Human Plasmacytoid Dendritic Cells Is Mediated by Dectin-2 and Results in Formation of Extracellular Traps

(2015) Flávio V. Loures et al.   PLoS Pathogens

IL-1α Signaling Is Critical for Leukocyte Recruitment after Pulmonary Aspergillus fumigatus Challenge

(2015) Alayna K. Caffrey et al.   PLoS Pathogens

Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection

(2015) Anupam Jhingran et al.   PLoS Pathogens

Diagnosis and Treatment of Pulmonary Aspergillosis Syndromes

(2014) Karen C Patterson et al.   CHEST

Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus

(2014) Jasmin Lother et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Protective immune responses to fungal infections

(2014) A. Rivera   PARASITE IMMUNOLOGY

Adaptive Immunity to Fungi

(2014) A. Verma et al.   Cold Spring Harbor Perspectives in Medicine

Inflammatory Monocytes Orchestrate Innate Antifungal Immunity in the Lung

(2014) Vanessa Espinosa et al.   PLoS Pathogens

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Dectin-2 is predominately macrophage restricted and exhibits conspicuous expression during Aspergillus fumigatus invasion in human lung

(2013) He Sun et al.   CELLULAR IMMUNOLOGY

Natural Killer Cells and Antifungal Host Response

(2013) Stanislaw Schmidt et al.   Clinical and Vaccine Immunology

Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen

(2013) Maud Plantinga et al.   IMMUNITY

Activation of NF-κB and respiratory burst following Aspergillus fumigatus stimulation of macrophages

(2013) He Sun et al.   IMMUNOBIOLOGY

Eosinophil Deficiency Compromises Lung Defense against Aspergillus fumigatus

(2013) Lauren M. Lilly et al.   INFECTION AND IMMUNITY

Monocyte- and Macrophage-Targeted NADPH Oxidase Mediates Antifungal Host Defense and Regulation of Acute Inflammation in Mice

(2013) M. J. Grimm et al.   JOURNAL OF IMMUNOLOGY

Adaptive Immunity to Fungi

(2012) Marcel Wüthrich et al.   Annual Review of Immunology

Dectin-1 is inducible and plays a crucial role in Aspergillus-induced innate immune responses in human bronchial epithelial cells

(2012) W.-K. Sun et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Fungi Subvert Vaccine T Cell Priming at the Respiratory Mucosa by Preventing Chemokine-Induced Influx of Inflammatory Monocytes

(2012) Marcel Wüthrich et al.   IMMUNITY

Species-Specific Recognition of Aspergillus fumigatus by Toll-like Receptor 1 and Toll-like Receptor 6

(2012) Ivana Rubino et al.   JOURNAL OF INFECTIOUS DISEASES

Aspergillus fumigatus Activates Thrombocytes by Secretion of Soluble Compounds

(2012) Cornelia Speth et al.   JOURNAL OF INFECTIOUS DISEASES

Compensatory dendritic cell development mediated by BATF–IRF interactions

(2012) Roxane Tussiwand et al.   NATURE

Characterisation of Innate Fungal Recognition in the Lung

(2012) Inês Faro-Trindade et al.   PLoS One

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

TLR3 essentially promotes protective class I-restricted memory CD8+ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients

(2011) A. Carvalho et al.   BLOOD

Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome

(2011) A. P. Hsu et al.   BLOOD

A Nonredundant Role for Plasmacytoid Dendritic Cells in Host Defense against the Human Fungal Pathogen Aspergillus fumigatus

(2011) Zaida G. Ramirez-Ortiz et al.   Cell Host & Microbe

Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent

(2011) Matteo Bianchi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dectin-1 diversifiesAspergillus fumigatus–specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation

(2011) Amariliz Rivera et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human NK Cells Display Important Antifungal Activity against Aspergillus fumigatus, Which Is Directly Mediated by IFN-  Release

(2011) M. Bouzani et al.   JOURNAL OF IMMUNOLOGY

Rapid Host Defense against Aspergillus fumigatus Involves Alveolar Macrophages with a Predominance of Alternatively Activated Phenotype

(2011) Shikha Bhatia et al.   PLoS One

The Temporal Dynamics of Differential Gene Expression in Aspergillus fumigatus Interacting with Human Immature Dendritic Cells In Vitro

(2011) Charles O. Morton et al.   PLoS One

Enemy of the (immunosuppressed) state: an update on the pathogenesis of Aspergillus fumigatus infection

(2010) Ronen Ben-Ami et al.   BRITISH JOURNAL OF HAEMATOLOGY

Dynamic Interplay among Monocyte-Derived, Dermal, and Resident Lymph Node Dendritic Cells during the Generation of Vaccine Immunity to Fungi

(2010) Karen Ersland et al.   Cell Host & Microbe

Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO

(2010) Antonella de Luca et al.   Cellular & Molecular Immunology

Antigen-Presenting Dendritic Cells Rescue CD4-Depleted CCR2-/- Mice from Lethal Histoplasma capsulatum Infection

(2010) W. A. Szymczak et al.   INFECTION AND IMMUNITY

CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice

(2010) Yue Si et al.   JOURNAL OF CLINICAL INVESTIGATION

Peripheral CD103+dendritic cells form a unified subset developmentally related to CD8α+conventional dendritic cells

(2010) Brian T. Edelson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR9 Is Actively Recruited to Aspergillus fumigatus Phagosomes and Requires the N-Terminal Proteolytic Cleavage Domain for Proper Intracellular Trafficking

(2010) P. V. Kasperkovitz et al.   JOURNAL OF IMMUNOLOGY

Trends in the postmortem epidemiology of invasive fungal infections at a university hospital

(2010) T. Lehrnbecher et al.   JOURNAL OF INFECTION

Human Natural Killer Cells Exhibit Direct Activity Against Aspergillus fumigatus Hyphae, But Not Against Resting Conidia

(2010) Stanislaw Schmidt et al.   JOURNAL OF INFECTIOUS DISEASES

Inhibition of neutrophil function following exposure to the Aspergillus fumigatus toxin fumagillin

(2010) J. P. Fallon et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Role of NADPH oxidase in host defense against aspergillosis

(2010) Melissa J. Grimm et al.   MEDICAL MYCOLOGY

NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus

(2010) Allison McCormick et al.   MICROBES AND INFECTION

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA

(2010) Sandra Bruns et al.   PLoS Pathogens

Innate Recognition of Fungal Cell Walls

(2010) Stuart M. Levitz   PLoS Pathogens

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

(2009) Cedric Auffray et al.   Annual Review of Immunology

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia

(2009) D. C. Vinh et al.   BLOOD

Inducible expression of beta defensins by human respiratory epithelial cells exposed to Aspergillus fumigatus organisms

(2009) Ludmila Alekseeva et al.   BMC MICROBIOLOGY

Inflammatory Monocytes Facilitate Adaptive CD4 T Cell Responses during Respiratory Fungal Infection

(2009) Tobias M. Hohl et al.   Cell Host & Microbe

Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis

(2009) T. R. T. Dagenais et al.   CLINICAL MICROBIOLOGY REVIEWS

Activation of Platelets by Aspergillus fumigatus and Potential Role of Platelets in the Immunopathogenesis of Aspergillosis

(2009) E. K. Rodland et al.   INFECTION AND IMMUNITY

The origin and development of nonlymphoid tissue CD103+DCs

(2009) Florent Ginhoux et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Requisite Role for the Dectin-1  -Glucan Receptor in Pulmonary Defense against Aspergillus fumigatus

(2009) J. L. Werner et al.   JOURNAL OF IMMUNOLOGY

Distinct Responses of Human Monocyte Subsets to Aspergillus fumigatus Conidia

(2009) N. V. Serbina et al.   JOURNAL OF IMMUNOLOGY

Early NK Cell-Derived IFN-  Is Essential to Host Defense in Neutropenic Invasive Aspergillosis

(2009) S. J. Park et al.   JOURNAL OF IMMUNOLOGY

The CCL7-CCL2-CCR2 Axis Regulates IL-4 Production in Lungs and Fungal Immunity

(2009) W. A. Szymczak et al.   JOURNAL OF IMMUNOLOGY

Aspergillus fumigatusInduces Immunoglobulin E–Independent Mast Cell Degranulation

(2009) Mirjam Urb et al.   JOURNAL OF INFECTIOUS DISEASES

Essential Role for Neutrophils but not Alveolar Macrophages at Early Time Points followingAspergillus fumigatusInfection

(2009) Monica M. Mircescu et al.   JOURNAL OF INFECTIOUS DISEASES

The innate immune response to Aspergillus fumigatus

(2009) Viviane Balloy et al.   MICROBES AND INFECTION

Surface hydrophobin prevents immune recognition of airborne fungal spores

(2009) Vishukumar Aimanianda et al.   NATURE

Aspergillosis

(2009) Brahm H. Segal   NEW ENGLAND JOURNAL OF MEDICINE

Monocyte-Mediated Defense Against Microbial Pathogens

(2008) Natalya V. Serbina et al.   Annual Review of Immunology

Toll-Like Receptor 9 Modulates Immune Responses to Aspergillus fumigatus Conidia in Immunodeficient and Allergic Mice

(2008) H. Ramaprakash et al.   INFECTION AND IMMUNITY

Toll-Like Receptor 9-Dependent Immune Activation by Unmethylated CpG Motifs in Aspergillus fumigatus DNA

(2008) Z. G. Ramirez-Ortiz et al.   INFECTION AND IMMUNITY

Aspergillus fumigatus-induced Interleukin-8 Synthesis by Respiratory Epithelial Cells Is Controlled by the Phosphatidylinositol 3-Kinase, p38 MAPK, and ERK1/2 Pathways and Not by the Toll-like Receptor-MyD88 Pathway

(2008) Viviane Balloy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proinflammatory Response of Immature Human Dendritic Cells is Mediated by Dectin‐1 after Exposure toAspergillus fumigatusGerm Tubes

(2008) Markus Mezger et al.   JOURNAL OF INFECTIOUS DISEASES

Human Platelets AttenuateAspergillusSpecies via Granule‐Dependent Mechanisms

(2008) Susanne Perkhofer et al.   JOURNAL OF INFECTIOUS DISEASES

Gliotoxin Production inAspergillus fumigatusContributes to Host‐Specific Differences in Virulence

(2008) Sara Spikes et al.   JOURNAL OF INFECTIOUS DISEASES