Protective immune responses to fungal infections

The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans

(2014) C. A. Wells et al.   JOURNAL OF IMMUNOLOGY

Differential Use of CARD9 by Dectin-1 in Macrophages and Dendritic Cells

(2014) H. S. Goodridge et al.   JOURNAL OF IMMUNOLOGY

Inflammatory Monocytes Orchestrate Innate Antifungal Immunity in the Lung

(2014) Vanessa Espinosa et al.   PLoS Pathogens

Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency

(2013) A. Drewniak et al.   BLOOD

Identification of Distinct Ligands for the C-type Lectin Receptors Mincle and Dectin-2 in the Pathogenic Fungus Malassezia

(2013) Tetsuaki Ishikawa et al.   Cell Host & Microbe

Genetic susceptibility toCandidainfections

(2013) Sanne P. Smeekens et al.   EMBO Molecular Medicine

C-Type Lectin Receptors Dectin-3 and Dectin-2 Form a Heterodimeric Pattern-Recognition Receptor for Host Defense against Fungal Infection

(2013) Le-Le Zhu et al.   IMMUNITY

C-type Lectin MCL Is an FcRγ-Coupled Receptor that Mediates the Adjuvanticity of Mycobacterial Cord Factor

(2013) Yasunobu Miyake et al.   IMMUNITY

Interferon-β Production via Dectin-1-Syk-IRF5 Signaling in Dendritic Cells Is Crucial for Immunity to C. albicans

(2013) Carlos del Fresno et al.   IMMUNITY

Endemic Fungal Infections in Inflammatory Bowel Disease Associated with Anti-TNF Antibody Therapy

(2013) Miguel E. Ordonez et al.   INFLAMMATORY BOWEL DISEASES

The Dectin-2 family of C-type lectin-like receptors: an update

(2013) Bernhard Kerscher et al.   INTERNATIONAL IMMUNOLOGY

Monocyte- and Macrophage-Targeted NADPH Oxidase Mediates Antifungal Host Defense and Regulation of Acute Inflammation in Mice

(2013) M. J. Grimm et al.   JOURNAL OF IMMUNOLOGY

Cord Factor and Peptidoglycan Recapitulate the Th17-Promoting Adjuvant Activity of Mycobacteria through Mincle/CARD9 Signaling and the Inflammasome

(2013) K. Shenderov et al.   JOURNAL OF IMMUNOLOGY

An Extracellular Matrix-Based Mechanism of Rapid Neutrophil Extracellular Trap Formation in Response to Candida albicans

(2013) A. S. Byrd et al.   JOURNAL OF IMMUNOLOGY

Inflammatory Monocytes Mediate Early and Organ-Specific Innate Defense During Systemic Candidiasis

(2013) Lisa Y. Ngo et al.   JOURNAL OF INFECTIOUS DISEASES

NFAT control of innate immunity

(2012) J. Fric et al.   BLOOD

Exciting Developments in the Immunology of Fungal Infections

(2012) Gordon D. Brown et al.   Cell Host & Microbe

Immunoglobulins in Defense, Pathogenesis, and Therapy of Fungal Diseases

(2012) Arturo Casadevall et al.   Cell Host & Microbe

Th17 Cells in Immunity to Candida albicans

(2012) Nydiaris Hernández-Santos et al.   Cell Host & Microbe

Dendritic Cells in Antifungal Immunity and Vaccine Design

(2012) René M. Roy et al.   Cell Host & Microbe

Immunity to fungi

(2012) Salomé LeibundGut-Landmann et al.   CURRENT OPINION IN IMMUNOLOGY

Immunity to infection in IL-17-deficient mice and humans

(2012) Sophie Cypowyj et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Invasive fungal infections in solid organ transplant recipients

(2012) Shmuel Shoham et al.   Future Microbiology

Fungi Subvert Vaccine T Cell Priming at the Respiratory Mucosa by Preventing Chemokine-Induced Influx of Inflammatory Monocytes

(2012) Marcel Wüthrich et al.   IMMUNITY

The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase

(2012) Lisa M. Graham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD4+ T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease

(2012) Antonella De Luca et al.   JOURNAL OF CLINICAL INVESTIGATION

Fungal antioxidant pathways promote survival against neutrophils during infection

(2012) Sixto M. Leal et al.   JOURNAL OF CLINICAL INVESTIGATION

ITAM-Coupled Receptors Inhibit IFNAR Signaling and Alter Macrophage Responses to TLR4 and Listeria monocytogenes

(2012) L. Huynh et al.   JOURNAL OF IMMUNOLOGY

Memory CD4+ T Cells Are Required for Optimal NK Cell Effector Functions against the Opportunistic Fungal Pathogen Pneumocystis murina

(2012) M. N. Kelly et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-17-Secreting Innate Lymphoid Cells Are Essential for Host Defense against Fungal Infection

(2012) A. Gladiator et al.   JOURNAL OF IMMUNOLOGY

Reactive Oxygen Species Produced by the NADPH Oxidase 2 Complex in Monocytes Protect Mice from Bacterial Infections

(2012) A. Pizzolla et al.   JOURNAL OF IMMUNOLOGY

A Novel Th Cell Epitope of Candida albicans Mediates Protection from Fungal Infection

(2012) E. Bar et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Toll-like Receptor 1 Polymorphisms Increase Susceptibility to Candidemia

(2012) Theo S. Plantinga et al.   JOURNAL OF INFECTIOUS DISEASES

Emerging fungal threats to animal, plant and ecosystem health

(2012) Matthew C. Fisher et al.   NATURE

Therapeutic potential of targeting IL-17

(2012) Sarah A Jones et al.   NATURE IMMUNOLOGY

The Index Case for the Fungal Meningitis Outbreak in the United States

(2012) April C. Pettit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Necrotizing Cutaneous Mucormycosis after a Tornado in Joplin, Missouri, in 2011

(2012) Robyn Neblett Fanfair et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dectin-1 and DC-SIGN Polymorphisms Associated with Invasive Pulmonary Aspergillosis Infection

(2012) Juan Sainz et al.   PLoS One

Cellular Responses of Candida albicans to Phagocytosis and the Extracellular Activities of Neutrophils Are Critical to Counteract Carbohydrate Starvation, Oxidative and Nitrosative Stress

(2012) Pedro Miramón et al.   PLoS One

Tackling Human Fungal Infections

(2012) G. D. Brown et al.   SCIENCE

Tracing Conidial Fate and Measuring Host Cell Antifungal Activity Using a Reporter of Microbial Viability in the Lung

(2012) Anupam Jhingran et al.   Cell Reports

Extracellular Superoxide Dismutase Protects Histoplasma Yeast Cells from Host-Derived Oxidative Stress

(2012) Brian H. Youseff et al.   PLoS Pathogens

Tc17 Cells Mediate Vaccine Immunity against Lethal Fungal Pneumonia in Immune Deficient Hosts Lacking CD4+ T Cells

(2012) Som Gowda Nanjappa et al.   PLoS Pathogens

Innate Antifungal Immunity: The Key Role of Phagocytes

(2011) Gordon D. Brown   Annual Review of Immunology

TLR3 essentially promotes protective class I-restricted memory CD8+ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients

(2011) A. Carvalho et al.   BLOOD

Generation of a multipathogen-specific T-cell product for adoptive immunotherapy based on activation-dependent expression of CD154

(2011) N. Khanna et al.   BLOOD

Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans

(2011) C. Stuehler et al.   BLOOD

A Nonredundant Role for Plasmacytoid Dendritic Cells in Host Defense against the Human Fungal Pathogen Aspergillus fumigatus

(2011) Zaida G. Ramirez-Ortiz et al.   Cell Host & Microbe

Innate Recognition of Cell Wall β-Glucans Drives Invariant Natural Killer T Cell Responses against Fungi

(2011) Nadia R. Cohen et al.   Cell Host & Microbe

Mechanisms of immune evasion in fungal pathogens

(2011) John R Collette et al.   CURRENT OPINION IN MICROBIOLOGY

The role of Dectin-1 in the host defence against fungal infections

(2011) Rebecca A Drummond et al.   CURRENT OPINION IN MICROBIOLOGY

Cytokines and the regulation of fungus-specific CD4 T cell differentiation

(2011) Vanessa Espinosa et al.   CYTOKINE

C-type lectin receptors and cytokines in fungal immunity

(2011) Simon Vautier et al.   CYTOKINE

Recognition of yeast nucleic acids triggers a host-protective type I interferon response

(2011) Carmelo Biondo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunization with Apoptotic Phagocytes Containing Histoplasma capsulatum Activates Functional CD8+T Cells To Protect against Histoplasmosis

(2011) Shih-Hung Hsieh et al.   INFECTION AND IMMUNITY

Blastomyces dermatitidis Yeast Cells Inhibit Nitric Oxide Production by Alveolar Macrophage Inducible Nitric Oxide Synthase

(2011) Nicole M. Rocco et al.   INFECTION AND IMMUNITY

Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice

(2011) Marcel Wüthrich et al.   JOURNAL OF CLINICAL INVESTIGATION

Dectin-1 diversifiesAspergillus fumigatus–specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation

(2011) Amariliz Rivera et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conventional Dendritic Cells Mount a Type I IFN Response against Candida spp. Requiring Novel Phagosomal TLR7-Mediated IFN-  Signaling

(2011) C. Bourgeois et al.   JOURNAL OF IMMUNOLOGY

A TCR Transgenic Mouse Reactive with Multiple Systemic Dimorphic Fungi

(2011) M. Wuthrich et al.   JOURNAL OF IMMUNOLOGY

The Y238X Stop Codon Polymorphism in the Human β-Glucan Receptor Dectin-1 and Susceptibility to Invasive Aspergillosis

(2011) Louis Y.A. Chai et al.   JOURNAL OF INFECTIOUS DISEASES

Genetic Variation in the Dectin-1/CARD9 Recognition Pathway and Susceptibility to Candidemia

(2011) Diana C. Rosentul et al.   JOURNAL OF INFECTIOUS DISEASES

Nitric oxide synthase activity has limited influence on the control of Coccidioides infection in mice

(2011) Angel Gonzalez et al.   MICROBIAL PATHOGENESIS

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

Role of NADPH Oxidase versus Neutrophil Proteases in Antimicrobial Host Defense

(2011) R. Robert Vethanayagam et al.   PLoS One

Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity

(2011) A. Puel et al.   SCIENCE

Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity

(2010) C. Cunha et al.   BLOOD

Dynamic Interplay among Monocyte-Derived, Dermal, and Resident Lymph Node Dendritic Cells during the Generation of Vaccine Immunity to Fungi

(2010) Karen Ersland et al.   Cell Host & Microbe

Epidemiology of Invasive Mycoses in North America

(2010) Michael A. Pfaller et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Fungal infections in oncology patients: update on epidemiology, prevention, and treatment

(2010) Kieren A Marr   CURRENT OPINION IN ONCOLOGY

Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans

(2010) Shinobu Saijo et al.   IMMUNITY

Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines

(2010) Kai Kisand et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR9 Is Actively Recruited to Aspergillus fumigatus Phagosomes and Requires the N-Terminal Proteolytic Cleavage Domain for Proper Intracellular Trafficking

(2010) P. V. Kasperkovitz et al.   JOURNAL OF IMMUNOLOGY

Neutropenia Enhances Lung Dendritic Cell Recruitment in Response to Aspergillus via a Cytokine-to-Chemokine Amplification Loop

(2010) S. J. Park et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate

(2010) H. Schoenen et al.   JOURNAL OF IMMUNOLOGY

Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans

(2010) Mohlopheni J. Marakalala et al.   MAMMALIAN GENOME

Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA

(2010) Sandra Bruns et al.   PLoS Pathogens

Innate Recognition of Fungal Cell Walls

(2010) Stuart M. Levitz   PLoS Pathogens

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Inflammatory Monocytes Facilitate Adaptive CD4 T Cell Responses during Respiratory Fungal Infection

(2009) Tobias M. Hohl et al.   Cell Host & Microbe

Modulation of Toll-Like Receptor 2 (TLR2) and TLR4 Responses by Aspergillus fumigatus

(2009) L. Y. A. Chai et al.   INFECTION AND IMMUNITY

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

(2009) Heather R. Conti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

(2009) Matthew J. Robinson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

(2009) Eri Ishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Exogenous Pentraxin 3 Restores Antifungal Resistance and Restrains Inflammation in Murine Chronic Granulomatous Disease

(2009) C. D'Angelo et al.   JOURNAL OF IMMUNOLOGY

Accumulation of CD11b+ Lung Dendritic Cells in Response to Fungal Infection Results from the CCR2-Mediated Recruitment and Differentiation of Ly-6Chigh Monocytes

(2009) J. J. Osterholzer et al.   JOURNAL OF IMMUNOLOGY

Requisite Role for the Dectin-1  -Glucan Receptor in Pulmonary Defense against Aspergillus fumigatus

(2009) J. L. Werner et al.   JOURNAL OF IMMUNOLOGY

Early NK Cell-Derived IFN-  Is Essential to Host Defense in Neutropenic Invasive Aspergillosis

(2009) S. J. Park et al.   JOURNAL OF IMMUNOLOGY

The CCL7-CCL2-CCR2 Axis Regulates IL-4 Production in Lungs and Fungal Immunity

(2009) W. A. Szymczak et al.   JOURNAL OF IMMUNOLOGY

Interleukins 17 and 23 Influence the Host Response toHistoplasma capsulatum

(2009) George S. Deepe et al.   JOURNAL OF INFECTIOUS DISEASES

Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-κB activation through Raf-1 and Syk

(2009) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections

(2009) Bart Ferwerda et al.   NEW ENGLAND JOURNAL OF MEDICINE

A HomozygousCARD9Mutation in a Family with Susceptibility to Fungal Infections

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

C-type lectin Mincle is an activating receptor for pathogenic fungus,Malassezia

(2009) Sho Yamasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Monocyte-Mediated Defense Against Microbial Pathogens

(2008) Natalya V. Serbina et al.   Annual Review of Immunology

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors

(2008) Kevin M. Dennehy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction

(2008) Luke A.J. O'Neill   IMMUNITY

Deficiency of Th17 cells in hyper IgE syndrome due to mutations inSTAT3

(2008) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

(2008) Luigina Romani et al.   NATURE

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

(2008) Joshua D. Milner et al.   NATURE

Mincle is an ITAM-coupled activating receptor that senses damaged cells

(2008) Sho Yamasaki et al.   NATURE IMMUNOLOGY

Toll-like Receptor 4 Polymorphisms and Aspergillosis in Stem-Cell Transplantation

(2008) Pierre-Yves Bochud et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

Dynamic, Morphotype-Specific Candida albicans β-Glucan Exposure during Infection and Drug Treatment

(2008) Robert T. Wheeler et al.   PLoS Pathogens