Targeting neuroinflammation in Alzheimer’s disease: evidence for NSAIDs and novel therapeutics

Why Did Tarenflurbil Fail in Alzheimer's Disease?

(2017) Bruno P. Imbimbo   JOURNAL OF ALZHEIMERS DISEASE

CHF5074, a Novel γ-Secretase Modulator, Restores Hippocampal Neurogenesis Potential and Reverses Contextual Memory Deficit in a Transgenic Mouse Model of Alzheimer's Disease

(2017) Bruno P. Imbimbo et al.   JOURNAL OF ALZHEIMERS DISEASE

Untangling the Web: Toxic and Protective Effects of Neuroinflammation and PGE2 Signaling in Alzheimer’s Disease

(2016) Nathaniel S. Woodling et al.   ACS Chemical Neuroscience

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

(2016) Adrian Olmos-Alonso et al.   BRAIN

T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer’s Disease

(2016) Ming Tong et al.   JOURNAL OF ALZHEIMERS DISEASE

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ADCOMS: a composite clinical outcome for prodromal Alzheimer's disease trials

(2016) Jinping Wang et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice

(2016) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease

(2016) Jeffrey L. Cummings et al.   Alzheimers Research & Therapy

Cyclooxygenase-1 null mice show reduced neuroinflammation in response to β-amyloid

(2016) Sang-Ho Choi et al.   Aging-US

Follow-up evaluation of cognitive function in the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial and its Follow-up Study

(2015)   Alzheimers & Dementia

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

The peroxisome proliferators activated receptor-gamma agonists as therapeutics for the treatment of Alzheimer's disease and mild-to-moderate Alzheimer's disease: a meta-analysis

(2015) Huawei Cheng et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases

(2015) Michele W L Teng et al.   NATURE MEDICINE

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

(2015) R. Scott Turner et al.   NEUROLOGY

Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial

(2015) J. Butchart et al.   NEUROLOGY

IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior

(2015) Paramita Chakrabarty et al.   NEURON

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid

(2015) V. Porrini et al.   NEUROSCIENCE

Resveratrol decreases the insoluble Aβ1–42 level in hippocampus and protects the integrity of the blood–brain barrier in AD rats

(2015) H.F. Zhao et al.   NEUROSCIENCE

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

(2015) Gerhard Leinenga et al.   Science Translational Medicine

Innate Immunity Fights Alzheimer's Disease

(2015) Marie-Victoire Guillot-Sestier et al.   TRENDS IN NEUROSCIENCES

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

(2015) Kuti Baruch et al.   Nature Communications

Effect of TTP488 in patients with mild to moderate Alzheimer’s disease

(2014) Aaron H Burstein et al.   BMC Neurology

Peroxisome Proliferator-Activated Receptor-Gamma Agonists for Alzheimer’s Disease and Amnestic Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

(2014) Jia Liu et al.   DRUGS & AGING

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Retinoic Acid Isomers Facilitate Apolipoprotein E Production and Lipidation in Astrocytes through the Retinoid X Receptor/Retinoic Acid Receptor Pathway

(2014) Jing Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pan-PPAR Modulation Effectively Protects APP/PS1 Mice from Amyloid Deposition and Cognitive Deficits

(2014) Markus P. Kummer et al.   MOLECULAR NEUROBIOLOGY

Clinical trial of an inhibitor of RAGE-A  interactions in Alzheimer disease

(2014) D. Galasko et al.   NEUROLOGY

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

(2014) Teng Jiang et al.   NEUROPSYCHOPHARMACOLOGY

Preclinical characterization of RO4602522, a novel, selective and orally active monoamine oxidase type B inhibitor for the treatment of Alzheimer's disease

(2013) Edilio Borroni et al.   Alzheimers & Dementia

Results of a follow-up study to the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT)

(2013)   Alzheimers & Dementia

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Innate Immunity in Alzheimer’s Disease: A Complex Affair

(2013) Marie-Victoire Guillot-Sestier et al.   CNS & Neurological Disorders-Drug Targets

Statins and Cognition: A Systematic Review and Meta-analysis of Short- and Long-term Cognitive Effects

(2013) Kristopher J. Swiger et al.   MAYO CLINIC PROCEEDINGS

Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events

(2013) Kiran Bhaskar et al.   NEUROBIOLOGY OF DISEASE

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Non-Steroidal Anti-Inflammatory Drugs and Alzheimers Disease: The Epidemiological Evidence

(2012) C.A. Szekely et al.   CNS & Neurological Disorders-Drug Targets

The role of astrocytes in amyloid β-protein toxicity and clearance

(2012) Dietmar Rudolf Thal   EXPERIMENTAL NEUROLOGY

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

(2012) Johannes vom Berg et al.   NATURE MEDICINE

Effects of omega-3 fatty acids on cognitive performance: a meta-analysis

(2012) Graham Mazereeuw et al.   NEUROBIOLOGY OF AGING

Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease

(2012) W. T. Hu et al.   NEUROLOGY

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

NSAID use does not affect dementia progression or survival in Alzheimer's disease. The Cache County Dementia Progression Study.

(2011) Trevor Buckley et al.   Alzheimers & Dementia

Extended results of the Alzheimer’s disease anti-inflammatory prevention trial

(2011) John C. Breitner et al.   Alzheimers & Dementia

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

(2011) Chia-Hsiung Chen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Why docosahexaenoic acid and aspirin supplementation could be useful in women as a primary prevention therapy against Alzheimer's disease?

(2010) Massimo F.L. Pomponi et al.   AGEING RESEARCH REVIEWS

Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease

(2010) Joseph F. Quinn et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Semisynthesis of novel monacolin J derivatives: hypocholesterolemic and neuroprotective activities

(2010) Sonia Campoy et al.   JOURNAL OF ANTIBIOTICS

Nonsteroidal Anti-Inflammatory Drugs, Aspirin, and Cognitive Function in the Baltimore Longitudinal Study of Aging

(2010) Shari R. Waldstein et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

A Randomized, Double-blind, Placebo Controlled-trial of Triflusal in Mild Cognitive Impairment

(2009) Teresa Gómez-Isla et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease

(2009) Fang Fang et al.   FASEB JOURNAL

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial

(2009) Robert C. Green   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Microglia Mediate the Clearance of Soluble A  through Fluid Phase Macropinocytosis

(2009) S. Mandrekar et al.   JOURNAL OF NEUROSCIENCE

Therapeutic potential of statins in Alzheimer's disease

(2009) Nagaendran Kandiah et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort

(2009) J.C.S. Breitner et al.   NEUROLOGY

Cognitive and Cerebral Metabolic Effects of Celecoxib Versus Placebo in People With Age-Related Memory Loss: Randomized Controlled Study

(2008) Gary W. Small et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Cognitive Function Over Time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT)

(2008)   ARCHIVES OF NEUROLOGY

Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer's disease

(2008) Edward L Tobinick et al.   BMC Neurology

Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity

(2008) Linda A. Kotilinek et al.   BRAIN

Cyclooxygenase-1 and -2 in the Different Stages of Alzheimers Disease Pathology

(2008) J. Hoozemans et al.   CURRENT PHARMACEUTICAL DESIGN

Possible Mechanisms of Action of NSAIDs and Related Compounds that Modulate γ - Secretase Cleavage

(2008) Thomas Kukar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

(2008) Gordon K Wilcock et al.   LANCET NEUROLOGY

Anti-Inflammatory Agents and Cognitive Decline in a Bi-Racial Population

(2008) Francine Grodstein et al.   NEUROEPIDEMIOLOGY

Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology

(2008) Z. Arvanitakis et al.   NEUROLOGY

Protective effects of NSAIDs on the development of Alzheimer disease

(2008) Steven C. Vlad et al.   NEUROLOGY

No advantage of A 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies

(2008) C. A. Szekely et al.   NEUROLOGY

No Effect of One-Year Treatment with Indomethacin on Alzheimer's Disease Progression: A Randomized Controlled Trial

(2008) Daniëlle de Jong et al.   PLoS One