The therapeutic potential of renin angiotensin aldosterone system (RAAS) in chronic pain: from preclinical studies to clinical trials

Fosinopril Prevents the Development of Tactile Allodynia in a Streptozotocin-Induced Diabetic Rat Model

(2015) Claudia Ivonne Araiza-Saldaña et al.   DRUG DEVELOPMENT RESEARCH

Mechanisms Underlying Clinical Efficacy of Angiotensin II Type 2 Receptor (AT2R) Antagonist EMA401 in Neuropathic Pain: Clinical Tissue and in Vitro Studies

(2015) Uma Anand et al.   Molecular Pain

Shaping mycolactone for therapeutic use against inflammatory disorders

(2015) Laure Guenin-Macé et al.   Science Translational Medicine

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways

(2014) Estelle Marion et al.   CELL

The Angiotensin II Type 2 Receptor for Pain Control

(2014) A.H. Jan Danser et al.   CELL

EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial

(2014) Andrew S C Rice et al.   LANCET

Effect of Subpressor Dose of Angiotensin II on Pain-Related Behavior in Relation with Neuronal Injury and Activation of Satellite Glial Cells in the Rat Dorsal Root Ganglia

(2013) Jaroslav Pavel et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Angiotensin II Receptor Type 2 Activation Is Required for Cutaneous Sensory Hyperinnervation and Hypersensitivity in a Rat Hind Paw Model of Inflammatory Pain

(2013) Anuradha Chakrabarty et al.   JOURNAL OF PAIN

Angiotensin II Produces Nociceptive Behavior through Spinal AT1 Receptor-Mediated p38 Mitogen-Activated Protein Kinase Activation in Mice

(2013) Wataru Nemoto et al.   Molecular Pain

Small Molecule Angiotensin II Type 2 Receptor (AT2R) Antagonists as Novel Analgesics for Neuropathic Pain: Comparative Pharmacokinetics, Radioligand Binding, and Efficacy in Rats

(2013) Maree T. Smith et al.   PAIN MEDICINE

A Small Molecule Angiotensin II Type 2 Receptor (AT2R) Antagonist Produces Analgesia in a Rat Model of Neuropathic Pain by Inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK Activation in the Dorsal Root Ganglia

(2013) Maree T. Smith et al.   PAIN MEDICINE

Analgesic Efficacy and Mode of Action of a Selective Small Molecule Angiotensin II Type 2 Receptor Antagonist in a Rat Model of Prostate Cancer-Induced Bone Pain

(2013) Arjun Muralidharan et al.   PAIN MEDICINE

Mineralocorticoid Receptor Blocker Eplerenone Reduces Pain Behaviors In Vivo and Decreases Excitability in Small-diameter Sensory Neurons from Local Inflamed Dorsal Root Ganglia In Vitro

(2012) Fei Dong et al.   ANESTHESIOLOGY

Neuropathic pain-attenuating potential of aliskiren in chronic constriction injury model in rats

(2012) Ankesh Kukkar et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Developmental expression patterns for angiotensin receptors in mouse skin and brain

(2012) Li Yu et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Angiotensin-(1–7) Induces Peripheral Antinociception through Mas Receptor Activation in an Opioid-Independent Pathway

(2012) Aline C.O. Costa et al.   PHARMACOLOGY

Protective effects of mineralocorticoid receptor blockade against neuropathy in experimental diabetic rats

(2011) H. Takata et al.   DIABETES OBESITY & METABOLISM

Exploring the potential of telmisartan in chronic constriction injury-induced neuropathic pain in rats

(2011) Amteshwar Singh Jaggi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Differential effect of spironolactone in chronic constriction injury and vincristine-induced neuropathic pain in rats

(2010) Amteshwar Singh Jaggi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Recommendations for the Pharmacological Management of Neuropathic Pain: An Overview and Literature Update

(2010) Robert H. Dworkin et al.   MAYO CLINIC PROCEEDINGS

Mas-related G-protein-coupled receptors inhibit pathological pain in mice

(2010) Y. Guan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intraneuronal angiotensinergic system in rat and human dorsal root ganglia

(2010) Jaspal Patil et al.   REGULATORY PEPTIDES

The association between ACE inhibitors and the complex regional pain syndrome: Suggestions for a neuro-inflammatory pathogenesis of CRPS

(2009) M. de Mos et al.   PAIN

Ameliorative Potential of Spironolactone in Diabetes Induced Hyperalgesia in Mice

(2009) Nadeem KHAN et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Expression and transport of Angiotensin II AT1 receptors in spinal cord, dorsal root ganglia and sciatic nerve of the rat

(2008) Jaroslav Pavel et al.   BRAIN RESEARCH

Estrogen Elicits Dorsal Root Ganglion Axon Sprouting via a Renin-Angiotensin System

(2008) Anuradha Chakrabarty et al.   ENDOCRINOLOGY

Ameliorative effects of amiloride and pralidoxime in chronic constriction injury and vincristine induced painful neuropathy in rats

(2008) Arunachalam Muthuraman et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Role of Inflammatory Cytokines in Diabetes and Its Complications

(2008) George L. King   JOURNAL OF PERIODONTOLOGY

Transient early expression of TNF-α in sciatic nerve and dorsal root ganglia in a mouse model of painful peripheral neuropathy

(2008) Paola Sacerdote et al.   NEUROSCIENCE LETTERS

Effects of spironolactone on human blood mononuclear cells: mineralocorticoid receptor independent effects on gene expression and late apoptosis induction

(2006) Søren Ulrik Salling Sønder et al.   BRITISH JOURNAL OF PHARMACOLOGY