Mechanisms Underlying Clinical Efficacy of Angiotensin II Type 2 Receptor (AT2R) Antagonist EMA401 in Neuropathic Pain: Clinical Tissue and in Vitro Studies
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mechanisms Underlying Clinical Efficacy of Angiotensin II Type 2 Receptor (AT2R) Antagonist EMA401 in Neuropathic Pain: Clinical Tissue and in Vitro Studies
Authors
Keywords
Angiotensin II, AngIII, Ang-(1-7), AT<sub>2</sub>R, Antagonist, EMA401, Human DRG neurons, Peripheral nerve injury, Calcium imaging, Hypersensitivity, Neuropathic pain, Neurites
Journal
Molecular Pain
Volume 11, Issue -, Pages s12990-015-0038
Publisher
SAGE Publications
Online
2015-06-25
DOI
10.1186/s12990-015-0038-x
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways
- (2014) Estelle Marion et al. CELL
- The Angiotensin II Type 2 Receptor for Pain Control
- (2014) A.H. Jan Danser et al. CELL
- EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial
- (2014) Andrew S C Rice et al. LANCET
- Cross-talk between inflammation and angiotensin II: Studies based on direct transfection of cardiomyocytes with AT1R and AT2R cDNA
- (2013) Wang Xianwei et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Angiotensin II Receptor Type 2 Activation Is Required for Cutaneous Sensory Hyperinnervation and Hypersensitivity in a Rat Hind Paw Model of Inflammatory Pain
- (2013) Anuradha Chakrabarty et al. JOURNAL OF PAIN
- Trophic factor and hormonal regulation of neurite outgrowth in sensory neuron-like 50B11 cells
- (2013) Aritra Bhattacherjee et al. NEUROSCIENCE LETTERS
- A Small Molecule Angiotensin II Type 2 Receptor (AT2R) Antagonist Produces Analgesia in a Rat Model of Neuropathic Pain by Inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK Activation in the Dorsal Root Ganglia
- (2013) Maree T. Smith et al. PAIN MEDICINE
- Analgesic Efficacy and Mode of Action of a Selective Small Molecule Angiotensin II Type 2 Receptor Antagonist in a Rat Model of Prostate Cancer-Induced Bone Pain
- (2013) Arjun Muralidharan et al. PAIN MEDICINE
- Angiotensin II type 2 receptor (AT2R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons
- (2012) U. Anand et al. EUROPEAN JOURNAL OF PAIN
- Intraneuronal angiotensinergic system in rat and human dorsal root ganglia
- (2010) Jaspal Patil et al. REGULATORY PEPTIDES
- The past, present and future of angiotensin II type 2 receptor stimulation
- (2009) U. Muscha Steckelings et al. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
- Development of selective non-peptide angiotensin II type 2 receptor agonsists
- (2009) Mathias Alterman JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
- Endogenous angiotensinergic system in neurons of rat and human trigeminal ganglia
- (2009) Hans Imboden et al. REGULATORY PEPTIDES
- MAP kinase and pain
- (2008) Ru-Rong Ji et al. BRAIN RESEARCH REVIEWS
- Estrogen Elicits Dorsal Root Ganglion Axon Sprouting via a Renin-Angiotensin System
- (2008) Anuradha Chakrabarty et al. ENDOCRINOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started