v-SNARE transmembrane domains function as catalysts for vesicle fusion

Synaptobrevin transmembrane domain determines the structure and dynamics of the SNARE motif and the linker region

(2016) Jing Han et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression

(2016) Rajit Rajappa et al.   Cell Reports

Phosphatidylserine-Dependent Catalysis of Stalk and Pore Formation by Synaptobrevin JMR-TMD Peptide

(2015) Pradip K. Tarafdar et al.   BIOPHYSICAL JOURNAL

Vacuolar SNARE Protein Transmembrane Domains Serve as Nonspecific Membrane Anchors with Unequal Roles in Lipid Mixing

(2015) Michel Pieren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion

(2015) Che-Wei Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Structural Role for the Synaptobrevin 2 Transmembrane Domain in Dense-Core Vesicle Fusion Pores

(2015) C.-W. Chang et al.   JOURNAL OF NEUROSCIENCE

Exocytotic fusion pores are composed of both lipids and proteins

(2015) Huan Bao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Behavior and Properties of Mature Lytic Granules at the Immunological Synapse of Human Cytotoxic T Lymphocytes

(2015) Min Ming et al.   PLoS One

Exocytotic fusion pores are composed of both lipids and proteins

(2015) Huan Bao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Coarse Grained Model for a Lipid Membrane with Physiological Composition and Leaflet Asymmetry

(2015) Satyan Sharma et al.   PLoS One

Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics

(2014) Madhurima Dhara et al.   JOURNAL OF CELL BIOLOGY

How Could SNARE Proteins Open a Fusion Pore?

(2014) Qinghua Fang et al.   PHYSIOLOGY

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

Going Backward: A Flexible Geometric Approach to Reverse Transformation from Coarse Grained to Atomistic Models

(2013) Tsjerk A. Wassenaar et al.   Journal of Chemical Theory and Computation

Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion during Neurotransmitter Release

(2013) Peng Zhou et al.   NEURON

Synaptobrevin2 is the v-SNARE required for cytotoxic T-lymphocyte lytic granule fusion

(2013) Ulf Matti et al.   Nature Communications

SNARE Proteins Synaptobrevin, SNAP-25, and Syntaxin Are Involved in Rapid and Slow Endocytosis at Synapses

(2013) Jianhua Xu et al.   Cell Reports

Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling

(2012) E. Fava et al.   DIABETOLOGIA

An Extension and Further Validation of an All-Atomistic Force Field for Biological Membranes

(2012) Joakim P. M. Jämbeck et al.   Journal of Chemical Theory and Computation

Membrane-Proximal Tryptophans of Synaptobrevin II Stabilize Priming of Secretory Vesicles

(2012) M. Borisovska et al.   JOURNAL OF NEUROSCIENCE

Molecular machines governing exocytosis of synaptic vesicles

(2012) Reinhard Jahn et al.   NATURE

SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open

(2012) L. Shi et al.   SCIENCE

Caught in the Act: Visualization of SNARE-Mediated Fusion Events in Molecular Detail

(2011) Herre Jelger Risselada et al.   CHEMBIOCHEM

VAMP4- and VAMP7-expressing vesicles are both required for cytotoxic granule exocytosis in NK cells

(2011) Konrad Krzewski et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The role of Synaptobrevin1/VAMP1 in Ca2+-triggered neurotransmitter release at the mouse neuromuscular junction

(2011) Yun Liu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Conserved conformational dynamics of membrane fusion protein transmembrane domains and flanking regions indicated by sequence statistics

(2011) Sindy Neumann et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Membrane Bending Energy and Fusion Pore Kinetics in Ca2+-Triggered Exocytosis

(2010) Zhen Zhang et al.   BIOPHYSICAL JOURNAL

Residue-Specific Side-Chain Packing Determines the Backbone Dynamics of Transmembrane Model Helices

(2010) Stefan Quint et al.   BIOPHYSICAL JOURNAL

Transmembrane-domain determinants for SNARE-mediated membrane fusion

(2010) E. Fdez et al.   JOURNAL OF CELL SCIENCE

SNARE Force Synchronizes Synaptic Vesicle Fusion and Controls the Kinetics of Quantal Synaptic Transmission

(2010) R. E. Guzman et al.   JOURNAL OF NEUROSCIENCE

Solvent-Exposed Tails as Prestalk Transition States for Membrane Fusion at Low Hydration

(2010) Yuliya G. Smirnova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of the synaptobrevin C terminus in fusion pore formation

(2010) A. N. Ngatchou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Protein-driven membrane stresses in fusion and fission

(2010) Michael M. Kozlov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Atomic-Resolution Simulations Predict a Transition State for Vesicle Fusion Defined by Contact of a Few Lipid Tails

(2010) Peter M. Kasson et al.   PLoS Computational Biology

Conflicting Views on the Membrane Fusion Machinery and the Fusion Pore

(2009) Jakob B. Sørensen   Annual Review of Cell and Developmental Biology

A solid-state NMR study of changes in lipid phase induced by membrane-fusogenic LV-peptides

(2009) Prashant Agrawal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Synaptotagmin-Mediated Bending of the Target Membrane Is a Critical Step in Ca2+-Regulated Fusion

(2009) Enfu Hui et al.   CELL

Helical extension of the neuronal SNARE complex into the membrane

(2009) Alexander Stein et al.   NATURE

A scissors mechanism for stimulation of SNARE-mediated lipid mixing by cholesterol

(2009) J. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Sequence-Specific Conformational Flexibility of SNARE Transmembrane Helices Probed by Hydrogen/Deuterium Exchange

(2008) Walter Stelzer et al.   BIOPHYSICAL JOURNAL

The MARTINI Coarse-Grained Force Field: Extension to Proteins

(2008) Luca Monticelli et al.   Journal of Chemical Theory and Computation

Supramolecular SNARE assembly precedes hemifusion in SNARE-mediated membrane fusion

(2008) Xiaobing Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY