How Could SNARE Proteins Open a Fusion Pore?

Fluorescent Amino Acids: Modular Building Blocks for the Assembly of New Tools for Chemical Biology

(2013) Andrew T. Krueger et al.   CHEMBIOCHEM

Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment

(2013) Alf Honigmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rapid structural change in synaptosomal-associated protein 25 (SNAP25) precedes the fusion of single vesicles with the plasma membrane in live chromaffin cells

(2013) Y. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical unzipping and rezipping of a single SNARE complex reveals hysteresis as a force-generating mechanism

(2013) Duyoung Min et al.   Nature Communications

Coarse-Grain Simulations Reveal Movement of the Synaptobrevin C-Terminus in Response to Piconewton Forces

(2012) Manfred Lindau et al.   BIOPHYSICAL JOURNAL

Juxtamembrane tryptophans of synaptobrevin 2 control the process of membrane fusion

(2012) Qinghua Fang et al.   FEBS LETTERS

Membrane-Proximal Tryptophans of Synaptobrevin II Stabilize Priming of Secretory Vesicles

(2012) M. Borisovska et al.   JOURNAL OF NEUROSCIENCE

Molecular machines governing exocytosis of synaptic vesicles

(2012) Reinhard Jahn et al.   NATURE

SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open

(2012) L. Shi et al.   SCIENCE

Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages

(2012) Y. Gao et al.   SCIENCE

Influenza Virus-Mediated Membrane Fusion: Determinants of Hemagglutinin Fusogenic Activity and Experimental Approaches for Assessing Virus Fusion

(2012) Brian S. Hamilton et al.   Viruses-Basel

Caught in the Act: Visualization of SNARE-Mediated Fusion Events in Molecular Detail

(2011) Herre Jelger Risselada et al.   CHEMBIOCHEM

Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation

(2011) Geert van den Bogaart et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion

(2011) Shyam S Krishnakumar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complexin cross-links prefusion SNAREs into a zigzag array

(2011) Daniel Kümmel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state

(2011) Feng Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Two synaptobrevin molecules are sufficient for vesicle fusion in central nervous system synapses

(2011) R. Sinha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Docking and Fast Fusion of Synaptobrevin Vesicles Depends on the Lipid Compositions of the Vesicle and the Acceptor SNARE Complex-Containing Target Membrane

(2010) Marta K. Domanska et al.   BIOPHYSICAL JOURNAL

Membrane Curvature in Synaptic Vesicle Fusion and Beyond

(2010) Harvey T. McMahon et al.   CELL

SNARE Conformational Changes that Prepare Vesicles for Exocytosis

(2010) Noriko Takahashi et al.   Cell Metabolism

Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis

(2010) Alexander M. Walter et al.   JOURNAL OF CELL BIOLOGY

SNARE Complex Zipping as a Driving Force in the Dilation of Proteinaceous Fusion Pores

(2010) Meyer B. Jackson   JOURNAL OF MEMBRANE BIOLOGY

One SNARE complex is sufficient for membrane fusion

(2010) Geert van den Bogaart et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of the synaptobrevin C terminus in fusion pore formation

(2010) A. N. Ngatchou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers

(2010) M. K. Knowles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The protein machinery of vesicle budding and fusion

(2010) James E. Rothman   PROTEIN SCIENCE

Fast Vesicle Fusion in Living Cells Requires at Least Three SNARE Complexes

(2010) R. Mohrmann et al.   SCIENCE

The Fusion of Membranes and Vesicles: Pathway and Energy Barriers from Dissipative Particle Dynamics

(2009) Andrea Grafmüller et al.   BIOPHYSICAL JOURNAL

Synaptotagmin-Mediated Bending of the Target Membrane Is a Critical Step in Ca2+-Regulated Fusion

(2009) Enfu Hui et al.   CELL

Helical extension of the neuronal SNARE complex into the membrane

(2009) Alexander Stein et al.   NATURE

A scissors mechanism for stimulation of SNARE-mediated lipid mixing by cholesterol

(2009) J. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion

(2009) A. Maximov et al.   SCIENCE

The Gaussian Curvature Elastic Energy of Intermediates in Membrane Fusion

(2008) David P. Siegel   BIOPHYSICAL JOURNAL

Phosphatidylinositol 4,5-bisphosphate regulates SNARE-dependent membrane fusion

(2008) Declan J. James et al.   JOURNAL OF CELL BIOLOGY

The Structural and Functional Implications of Linked SNARE Motifs in SNAP25

(2008) Li Wang et al.   MOLECULAR BIOLOGY OF THE CELL

The role of the C terminus of the SNARE protein SNAP-25 in fusion pore opening and a model for fusion pore mechanics

(2008) Q. Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA