BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer
Authors
Keywords
-
Journal
eLife
Volume 5, Issue -, Pages -
Publisher
eLife Sciences Organisation, Ltd.
Online
2016-08-16
DOI
10.7554/elife.16620
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy
- (2016) Ryan M. Naylor et al. JOURNAL OF CLINICAL INVESTIGATION
- The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation
- (2016) Luying Jia et al. Nature Communications
- MYC Is a Major Determinant of Mitotic Cell Fate
- (2015) Caroline Topham et al. CANCER CELL
- The ABBA Motif Binds APC/C Activators and Is Shared by APC/C Substrates and Regulators
- (2015) Barbara Di Fiore et al. DEVELOPMENTAL CELL
- Targeting the Mitotic Catastrophe Signaling Pathway in Cancer
- (2015) Margaret M. Mc Gee MEDIATORS OF INFLAMMATION
- BubR1 kinase: protection against aneuploidy and premature aging
- (2015) Maria Kapanidou et al. TRENDS IN MOLECULAR MEDICINE
- Aneuploidy and chromosomal instability in cancer: a jackpot to chaos
- (2015) Maybelline Giam et al. Cell Division
- Nuclear Pores Protect Genome Integrity by Assembling a Premitotic and Mad1-Dependent Anaphase Inhibitor
- (2014) Veronica Rodriguez-Bravo et al. CELL
- Effect of DNA Repair Deficiencies on the Cytotoxicity of Drugs Used in Cancer Therapy - A Review
- (2014) Jose Calderon-Montano et al. CURRENT MEDICINAL CHEMISTRY
- SIRT2 induces the checkpoint kinase BubR1 to increase lifespan
- (2014) B. J. North et al. EMBO JOURNAL
- The Cdc20-binding Phe Box of the Spindle Checkpoint Protein BubR1 Maintains the Mitotic Checkpoint Complex During Mitosis
- (2014) Laura A. Diaz-Martinez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing
- (2014) Antonio Espert et al. JOURNAL OF CELL BIOLOGY
- The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C
- (2014) Daisuke Izawa et al. NATURE
- The internal Cdc20 binding site in BubR1 facilitates both spindle assembly checkpoint signalling and silencing
- (2014) Tiziana Lischetti et al. Nature Communications
- Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome
- (2013) Teresa Davoli et al. CELL
- Aneuploidy in health, disease, and aging
- (2013) Robin M. Ricke et al. JOURNAL OF CELL BIOLOGY
- Catalytic Assembly of the Mitotic Checkpoint Inhibitor BubR1-Cdc20 by a Mad2-Induced Functional Switch in Cdc20
- (2013) Joo Seok Han et al. MOLECULAR CELL
- The causes and consequences of genetic heterogeneity in cancer evolution
- (2013) Rebecca A. Burrell et al. NATURE
- The MPS1 Family of Protein Kinases
- (2012) Xuedong Liu et al. Annual Review of Biochemistry
- The Vertebrate Mitotic Checkpoint Protein BUBR1 Is an Unusual Pseudokinase
- (2012) Saskia J.E. Suijkerbuijk et al. DEVELOPMENTAL CELL
- Integration of Kinase and Phosphatase Activities by BUBR1 Ensures Formation of Stable Kinetochore-Microtubule Attachments
- (2012) Saskia J.E. Suijkerbuijk et al. DEVELOPMENTAL CELL
- Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression
- (2012) Robin M. Ricke et al. JOURNAL OF CELL BIOLOGY
- Structure of the mitotic checkpoint complex
- (2012) William C. H. Chao et al. NATURE
- Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
- (2012) Darren J. Baker et al. NATURE CELL BIOLOGY
- Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons
- (2012) S. D. Ryan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recurrent Hemizygous Deletions in Cancers May Optimize Proliferative Potential
- (2012) N. L. Solimini et al. SCIENCE
- Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation
- (2012) Tobias Wijshake et al. PLoS Genetics
- Identification of Aneuploidy-Selective Antiproliferation Compounds
- (2011) Yun-Chi Tang et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation
- (2011) Robin M. Ricke et al. JOURNAL OF CELL BIOLOGY
- Bub1 and BubR1: at the Interface between Chromosome Attachment and the Spindle Checkpoint
- (2011) S. Elowe MOLECULAR AND CELLULAR BIOLOGY
- Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation
- (2011) Maria Maldonado et al. NATURE CELL BIOLOGY
- Mutations in CEP57 cause mosaic variegated aneuploidy syndrome
- (2011) Katie Snape et al. NATURE GENETICS
- Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling
- (2010) John Maciejowski et al. JOURNAL OF CELL BIOLOGY
- Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation
- (2010) Janine H. van Ree et al. JOURNAL OF CELL BIOLOGY
- Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex
- (2010) Laura Hewitt et al. JOURNAL OF CELL BIOLOGY
- Microtubule-binding agents: a dynamic field of cancer therapeutics
- (2010) Charles Dumontet et al. NATURE REVIEWS DRUG DISCOVERY
- Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity
- (2009) Darren J. Baker et al. CANCER CELL
- BubR1 N Terminus Acts as a Soluble Inhibitor of Cyclin B Degradation by APC/CCdc20 in Interphase
- (2009) Liviu A. Malureanu et al. DEVELOPMENTAL CELL
- Unattached Kinetochores Catalyze Production of an Anaphase Inhibitor that Requires a Mad2 Template to Prime Cdc20 for BubR1 Binding
- (2009) Anita Kulukian et al. DEVELOPMENTAL CELL
- Constitutional aneuploidy and cancer predisposition
- (2009) I. Ganmore et al. HUMAN MOLECULAR GENETICS
- Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1
- (2009) S. Elowe et al. JOURNAL OF CELL SCIENCE
- Clinical and genetic heterogeneity in patients with mosaic variegated aneuploidy: Delineation of clinical subtypes
- (2008) Herbert García‐Castillo et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs
- (2008) Karen E. Gascoigne et al. CANCER CELL
- Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
- (2008) Darren J. Baker et al. NATURE CELL BIOLOGY
- Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells
- (2008) B. R. Williams et al. SCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started