The Cleavage Effect of Mesenchymal Stem Cell and Its Derived Matrix Metalloproteinase-2 on Extracellular α-Synuclein Aggregates in Parkinsonian Models

Mesenchymal Stem Cells Inhibit Transmission of α-Synuclein by Modulating Clathrin-Mediated Endocytosis in a Parkinsonian Model

(2016) Se Hee Oh et al.   Cell Reports

Mesenchymal stem cells secretome as a modulator of the neurogenic niche: basic insights and therapeutic opportunities

(2015) Antonio J. Salgado et al.   Frontiers in Cellular Neuroscience

Neuroprotective effects of mesenchymal stem cells through autophagy modulation in a parkinsonian model

(2014) Hyun Jung Park et al.   NEUROBIOLOGY OF AGING

Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models

(2013) Jin Young Shin et al.   Autophagy

The secretome of mesenchymal stem cells: Potential implications for neuroregeneration

(2013) Gesine Paul et al.   BIOCHIMIE

Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation

(2013) Therese Fagerqvist et al.   JOURNAL OF NEUROCHEMISTRY

MMP-3 Contributes to Nigrostriatal Dopaminergic Neuronal Loss, BBB Damage, and Neuroinflammation in an MPTP Mouse Model of Parkinson’s Disease

(2013) Young Cheul Chung et al.   MEDIATORS OF INFLAMMATION

Immunotherapy for neurodegenerative diseases: Focus on α-synucleinopathies

(2013) Elvira Valera et al.   PHARMACOLOGY & THERAPEUTICS

Proteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson disease

(2013) Sang Myun Park et al.   Prion

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

(2013) Takeshi Katsuda et al.   Scientific Reports

Mesenchymal Stem Cells Augment Neurogenesis in the Subventricular Zone and Enhance Differentiation of Neural Precursor Cells into Dopaminergic Neurons in the Substantia Nigra of a Parkinsonian Model

(2012) Hyun-Jung Park et al.   CELL TRANSPLANTATION

Matrix Metalloproteinase-9 Reduces Islet Amyloid Formation by Degrading Islet Amyloid Polypeptide

(2012) Kathryn Aston-Mourney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective effects of human umbilical cord mesenchymal stromal cells in an immunocompetent animal model of Parkinson's disease

(2012) Patricia Mathieu et al.   JOURNAL OF NEUROIMMUNOLOGY

Antibody-Aided Clearance of Extracellular  -Synuclein Prevents Cell-to-Cell Aggregate Transmission

(2012) E.-J. Bae et al.   JOURNAL OF NEUROSCIENCE

Therapeutic potential of mesenchymal stem cell-derived microvesicles

(2012) L. Biancone et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Alpha-synuclein: from secretion to dysfunction and death

(2012) O Marques et al.   Cell Death & Disease

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteomic Analysis of Microvesicles Derived from Human Mesenchymal Stem Cells

(2011) Han-Soo Kim et al.   JOURNAL OF PROTEOME RESEARCH

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

(2011) Eliezer Masliah et al.   PLoS One

Neuroprotective Effect of Human Mesenchymal Stem Cells in an Animal Model of Double Toxin-Induced Multiple System Atrophy Parkinsonism

(2010) Hyun-Jung Park et al.   CELL TRANSPLANTATION

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Modulation of α-Synuclein Aggregation by Dopamine: A Review

(2009) Su Ling Leong et al.   NEUROCHEMICAL RESEARCH

Rifampicin reduces α-synuclein in a transgenic mouse model of multiple system atrophy

(2009) Kiren Ubhi et al.   NEUROREPORT

Matrix metalloproteinases-2 and -3 are reduced in cerebrospinal fluid with low beta-amyloid1–42 levels

(2009) Reinhilde Mlekusch et al.   NEUROSCIENCE LETTERS

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased α-synuclein aggregation following limited cleavage by certain matrix metalloproteinases

(2008) Johannes Levin et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti-inflammatory action

(2008) You-Joung Kim et al.   GLIA

Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

(2008) Christophe Lo Bianco et al.   JOURNAL OF CLINICAL INVESTIGATION

Mesenchymal stem cells therapy exerts neuroprotection in a progressive animal model of Parkinson’s disease

(2008) Hyun Jung Park et al.   JOURNAL OF NEUROCHEMISTRY

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE