Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

(2013) Andrew T. McGuire et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

(2013) Masashi Shingai et al.   NATURE

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

(2013) Dan H. Barouch et al.   NATURE

HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

(2013) J. A. Horwitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibodies in HIV-1 Vaccine Development and Therapy

(2013) F. Klein et al.   SCIENCE

Isolation of antibody V(D)J sequences from single cell sorted rhesus macaque B cells

(2012) Christopher Sundling et al.   JOURNAL OF IMMUNOLOGICAL METHODS

HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

(2012) Florian Klein et al.   NATURE

A mouse model for HIV-1 entry

(2012) J. Pietzsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo

(2012) B. Moldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Most rhesus macaques infected with the CCR5-tropic SHIVAD8 generate cross-reactive antibodies that neutralize multiple HIV-1 strains

(2012) M. Shingai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

(2012) H. Mouquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Resolution Definition of Vaccine-Elicited B Cell Responses Against the HIV Primary Receptor Binding Site

(2012) C. Sundling et al.   Science Translational Medicine

Antibody-based protection against HIV infection by vectored immunoprophylaxis

(2011) Alejandro B. Balazs et al.   NATURE

Broad neutralization coverage of HIV by multiple highly potent antibodies

(2011) Laura M. Walker et al.   NATURE

Memory B Cell Antibodies to HIV-1 gp140 Cloned from Individuals Infected with Clade A and B Viruses

(2011) Hugo Mouquet et al.   PLoS One

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

(2011) J. F. Scheid et al.   SCIENCE

Structural Conservation Predominates Over Sequence Variability in the Crown of HIV Type 1's V3 Loop

(2010) David Almond et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates

(2010) Christopher Sundling et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human anti–HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness

(2010) John Pietzsch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutation at a Single Position in the V2 Domain of the HIV-1 Envelope Protein Confers Neutralization Sensitivity to a Highly Neutralization-Resistant Virus

(2010) S. M. O'Rourke et al.   JOURNAL OF VIROLOGY

Conserved structural elements in the V3 crown of HIV-1 gp120

(2010) Xunqing Jiang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Anti-V3 Monoclonal Antibodies Display Broad Neutralizing Activities against Multiple HIV-1 Subtypes

(2010) Catarina E. Hioe et al.   PLoS One

Temporal analysis of HIV envelope sequence evolution and antibody escape in a subtype A-infected individual with a broad neutralizing antibody response

(2010) Katherine A. Bosch et al.   VIROLOGY

Structure-guided design and immunological characterization of immunogens presenting the HIV-1 gp120 V3 loop on a CTB scaffold

(2010) Maxim Totrov et al.   VIROLOGY

B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection

(2010) Kuan-Hsiang G. Huang et al.   Nature Communications

Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain

(2009) T. Gaufin et al.   BLOOD

Effect of B-Cell Depletion on Viral Replication and Clinical Outcome of Simian Immunodeficiency Virus Infection in a Natural Host

(2009) T. Gaufin et al.   JOURNAL OF VIROLOGY

Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies

(2009) M. S. Seaman et al.   JOURNAL OF VIROLOGY

Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm

(2009) M. D. Simek et al.   JOURNAL OF VIROLOGY

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

(2009) Johannes F. Scheid et al.   NATURE

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Structural Basis of the Cross-Reactivity of Genetically Related Human Anti-HIV-1 mAbs: Implications for Design of V3-Based Immunogens

(2009) Valicia Burke et al.   STRUCTURE

Frequency and Phenotype of Human Immunodeficiency Virus Envelope-Specific B Cells from Patients with Broadly Cross-Neutralizing Antibodies

(2008) N. A. Doria-Rose et al.   JOURNAL OF VIROLOGY

Autologous Neutralizing Humoral Immunity and Evolution of the Viral Envelope in the Course of Subtype B Human Immunodeficiency Virus Type 1 Infection

(2008) E. M. Bunnik et al.   JOURNAL OF VIROLOGY

Enhancing Exposure of HIV-1 Neutralization Epitopes through Mutations in gp41

(2007) Catherine A Blish et al.   PLOS MEDICINE