TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control TH2-Mediated Immunopathology

Strategies and endpoints of antifibrotic drug trials: Summary and recommendations from the AASLD Emerging Trends Conference, Chicago, June 2014

(2015) Natalie J. Torok et al.   HEPATOLOGY

Implication of the Tpl2 Kinase in Inflammatory Changes and Insulin Resistance Induced by the Interaction Between Adipocytes and Macrophages

(2014) Franck Ceppo et al.   ENDOCRINOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

3, 3′-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance

(2014) Yun Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Tumor Progression Locus 2 (Tpl2) Kinase Promotes Chemokine Receptor Expression and Macrophage Migration during Acute Inflammation

(2014) Sean M. Rowley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-4R  Expression by Bone Marrow-Derived Cells Is Necessary and Sufficient for Host Protection against Acute Schistosomiasis

(2014) D. R. Herbert et al.   JOURNAL OF IMMUNOLOGY

Regulation of Experimental Autoimmune Encephalomyelitis by TPL-2 Kinase

(2014) S. Sriskantharajah et al.   JOURNAL OF IMMUNOLOGY

T Cell–Derived IL-4/IL-13 Protects Mice against FatalSchistosoma mansoniInfection Independently of Basophils

(2014) Christian Schwartz et al.   JOURNAL OF IMMUNOLOGY

Cot/tpl2 participates in the activation of macrophages by adiponectin

(2014) Carlos Sanz-Garcia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

Incomplete Deletion of IL-4Rα by LysMCre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis

(2014) Kevin M. Vannella et al.   PLoS Pathogens

TPL-2-ERK1/2 Signaling Promotes Host Resistance against Intracellular Bacterial Infection by Negative Regulation of Type I IFN Production

(2013) F. W. McNab et al.   JOURNAL OF IMMUNOLOGY

PKC and ERK mediate GH-stimulated lipolysis

(2013) Heather E Bergan et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Estradiol Represses the GD3 Synthase Gene ST8SIA1 Expression in Human Breast Cancer Cells by Preventing NFκB Binding to ST8SIA1 Promoter

(2013) Marie Bobowski et al.   PLoS One

Pivotal Role of Matrix Metalloproteinase 13 in Extracellular Matrix Turnover in Idiopathic Pulmonary Fibrosis

(2013) Takwi Nkyimbeng et al.   PLoS One

Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis

(2013) G. Larrouy-Maumus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrosis-Associated Single-Nucleotide Polymorphisms in TGFB1 and CAV1 Are Not Associated With the Development of Nephrogenic Systemic Fibrosis

(2012) Long P. Le et al.   AMERICAN JOURNAL OF DERMATOPATHOLOGY

Host Responses in Tissue Repair and Fibrosis

(2012) Jeremy S. Duffield et al.   Annual Review of Pathology-Mechanisms of Disease

LPS-induced chemokine expression in both MyD88-dependent and -independent manners is regulated by Cot/Tpl2-ERK axis in macrophages

(2012) Kenjiro Bandow et al.   FEBS LETTERS

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

(2012) Fanli Meng et al.   GASTROENTEROLOGY

Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice

(2012) Maria J. Perugorria et al.   HEPATOLOGY

IκB kinase regulation of the TPL-2/ERK MAPK pathway

(2012) Thorsten Gantke et al.   IMMUNOLOGICAL REVIEWS

Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis

(2012) Vasiliki Koliaraki et al.   JOURNAL OF CLINICAL INVESTIGATION

Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor–activated macrophages

(2012) Marta López-Pelaéz et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation

(2012) O. B. Serebrennikova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid metabolism in mammalian tissues and its control by retinoic acid

(2011) M. Luisa Bonet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression

(2011) Marta López-Peláez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage activation governs schistosomiasis-induced inflammation and fibrosis

(2011) Luke Barron et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages

(2010) Fina Lovren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

(2010) Thorsten Gantke et al.   CELL RESEARCH

Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent

(2010) Mark S. Wilson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity

(2010) D. A. Hume   JOURNAL OF LEUKOCYTE BIOLOGY

Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-α production in human whole blood

(2009) Junjun Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ADAM19/Adamalysin 19 Structure, Function, and Role as a Putative Target in Tumors and Inflammatory Diseases

(2009) Bin Qi et al.   CURRENT PHARMACEUTICAL DESIGN

Cot/Tpl-2 Protein Kinase as a Target for the Treatment of Inflammatory Disease

(2009) D. George et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Tpl2 Kinase Is Upregulated in Adipose Tissue in Obesity and May Mediate Interleukin-1  and Tumor Necrosis Factor-  Effects on Extracellular Signal-Regulated Kinase Activation and Lipolysis

(2009) J. Jager et al.   DIABETES

Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung

(2009) Meera G. Nair et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ablation of Tumor Progression Locus 2 Promotes a Type 2 Th Cell Response in Ovalbumin-Immunized Mice

(2009) Wendy T. Watford et al.   JOURNAL OF IMMUNOLOGY

Tumor Progression Locus 2 (Map3k8) Is Critical for Host Defense against Listeria monocytogenes and IL-1  Production

(2009) L. A. Mielke et al.   JOURNAL OF IMMUNOLOGY

Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity

(2009) John T. Pesce et al.   PLoS Pathogens

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

Deregulation of Tpl2 and NF-κB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium

(2008) Minying Zhang et al.   CELLULAR SIGNALLING

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF  in LPS-stimulated macrophages

(2008) S. Rousseau et al.   JOURNAL OF CELL SCIENCE

Analysis of hydrophilic metabolites by high-performance liquid chromatography–mass spectrometry using a silica hydride-based stationary phase

(2008) Joseph J. Pesek et al.   JOURNAL OF CHROMATOGRAPHY A

Tpl2 kinase regulates T cell interferon-γ production and host resistance toToxoplasma gondii

(2008) Wendy T. Watford et al.   JOURNAL OF EXPERIMENTAL MEDICINE