Soluble Egg Antigens of Schistosoma japonicum Induce Senescence of Activated Hepatic Stellate Cells by Activation of the FoxO3a/SKP2/P27 Pathway

MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression

(2016) Jeongeun Hyun et al.   Nature Communications

Soluble egg antigens of Schistosoma japonicum induce senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway

(2016) Jinling Chen et al.   Scientific Reports

Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis

(2016) Mio Kitano et al.   Journal of Clinical Medicine

FoxO3a suppresses the senescence of cardiac microvascular endothelial cells by regulating the ROS-mediated cell cycle

(2015) Xu-Feng Qi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes

(2015) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

Expression of Septin4 in Schistosoma japonicum-infected mouse livers after praziquantel treatment

(2015) Dandan Zhu et al.   Parasites & Vectors

Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways

(2015) Cong Fu et al.   Oncotarget

Resveratrol Prevents Oxidative Stress-Induced Senescence and Proliferative Dysfunction by Activating the AMPK-FOXO3 Cascade in Cultured Primary Human Keratinocytes

(2015) Yasuo Ido et al.   PLoS One

High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle

(2015) Juan M. Caraballo et al.   Oncotarget

A new histone deacetylase inhibitor improves liver fibrosis in BDL rats through suppression of hepatic stellate cells

(2014) Ki Cheong Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ablation of galectin-3 induces p27KIP1-dependent premature senescence without oncogenic stress

(2014) S-J Kim et al.   CELL DEATH AND DIFFERENTIATION

Overexpression of protein kinase B/AKT induces phosphorylation of p70S6K and 4E-BP1 in goat fetal fibroblasts

(2014) K.L. Ma et al.   GENETICS AND MOLECULAR RESEARCH

Schistosoma japonicum soluble egg antigens induce apoptosis and inhibit activation of hepatic stellate cells: a possible molecular mechanism

(2014) Yinong Duan et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Decreased Skp2 Expression Is Necessary but Not Sufficient for Therapy-Induced Senescence in Prostate Cancer

(2014) Jonathan A. Ewald et al.   Translational Oncology

BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells

(2014) J-J Lee et al.   Cell Death & Disease

Crosstalk between the Rb Pathway and AKT Signaling Forms a Quiescence-Senescence Switch

(2014) Yoshinori Imai et al.   Cell Reports

Schistosoma japonicum scFv-IL18 fusion DNA ameliorates hepatic fibrosis in schistosomiasis-infected mice via improving local concentration of IL-18 in liver

(2013) Zhi Tian et al.   EXPERIMENTAL PARASITOLOGY

Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic Myofibroblasts

(2013) K.-H. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Clearance of activated stellate cells for hepatic fibrosis regression: Molecular basis and translational potential

(2012) Desong Kong et al.   BIOMEDICINE & PHARMACOTHERAPY

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

Clinical evidence for the regression of liver fibrosis

(2012) Elizabeth L. Ellis et al.   JOURNAL OF HEPATOLOGY

Bimodal regulation of FoxO3 by AKT and 14-3-3

(2011) Melissa Dobson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β

(2011) Ning-Ping Foo et al.   TOXICOLOGY

Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis

(2011) Guocan Wang et al.   Chinese Journal of Cancer

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

(2008) Arthur P. Young et al.   NATURE CELL BIOLOGY

Hepatic fibrosis—Overview

(2008) Scott L. Friedman   TOXICOLOGY

Fucoidan partly prevents CCl4-induced liver fibrosis

(2007) Shinji Hayashi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY