Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response

Exome-wide single-base substitutions in tissues and derived cell lines of the constitutive Fhit knockout mouse

(2016) Carolyn A. Paisie et al.   CANCER SCIENCE

Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells

(2016) Pei-Chi Wei et al.   CELL

Finding DNA Ends within a Haystack of Chromatin

(2016) Ujjwal Banerjee et al.   MOLECULAR CELL

Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells

(2016) Bjoern Schwer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Replication Stress as a Hallmark of Cancer

(2015) Morgane Macheret et al.   Annual Review of Pathology-Mechanisms of Disease

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

(2015) Ram Madabhushi et al.   CELL

Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells

(2015) Muhannad Abu-Remaileh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1

(2015) Seung Baek Lee et al.   MOLECULAR CELL

DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study

(2015) Hon-Yi Lin et al.   Oncotarget

WW domain-containing oxidoreductase in neuronal injury and neurological diseases

(2015) Hsin-Tzu Chang et al.   Oncotarget

Loss of Heterozygosity and Copy Number Abnormality in Clear Cell Renal Cell Carcinoma Discovered by High-Density Affymetrix 10K Single Nucleotide Polymorphism Mapping Array

(2015) Marieta I. Toma et al.   NEOPLASIA

Interplay between genetic and epigenetic factors governs common fragile site instability in cancer

(2014) Efrat Ozeri-Galai et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Very large common fragile site genes and their potential role in cancer development

(2014) Ge Gao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Role of common fragile sites and corresponding genes in cancer development

(2014) Rami I. Aqeilan   CELLULAR AND MOLECULAR LIFE SCIENCES

The FHIT gene product: tumor suppressor and genome “caretaker”

(2014) Catherine E. Waters et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Are common fragile sites merely structural domains or highly organized “functional” units susceptible to oncogenic stress?

(2014) Alexandros G. Georgakilas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Updating the mechanisms of common fragile site instability: how to reconcile the different views?

(2014) Benoît Le Tallec et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The common fragile site FRA16D gene product WWOX: roles in tumor suppression and genomic stability

(2014) Rami I. Aqeilan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

WW domain-containing oxidoreductase’s role in myriad cancers: Clinical significance and future implications

(2014) Aliza Gardenswartz et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism

(2014) Muhannad Abu-Remaileh et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Large transcription units unify copy number variants and common fragile sites arising under replication stress

(2014) Thomas E. Wilson et al.   GENOME RESEARCH

Characterizing WW Domain Interactions of Tumor Suppressor WWOX Reveals Its Association with Multiprotein Networks

(2014) Mohammad Abu-Odeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WWOX-related encephalopathies: delineation of the phenotypical spectrum and emerging genotype-phenotype correlation

(2014) Cyril Mignot et al.   JOURNAL OF MEDICAL GENETICS

A Novel Whole Exon Deletion in WWOX Gene Causes Early Epilepsy, Intellectual Disability and Optic Atrophy

(2014) Salma Ben-Salem et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins

(2014) Yongxing Gong et al.   NATURE GENETICS

The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration

(2014) Ghada Abdel-Salam et al.   Orphanet Journal of Rare Diseases

WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response

(2014) M. Abu-Odeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FHIT Suppresses Epithelial-Mesenchymal Transition (EMT) and Metastasis in Lung Cancer through Modulation of MicroRNAs

(2014) Sung-Suk Suh et al.   PLoS Genetics

The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation

(2013) Martial Mallaret et al.   BRAIN

Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146, CEBPD and PRKDC genes in colorectal cancer

(2013) Lena M. Brueckner et al.   CANCER LETTERS

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

(2013) K Evangelou et al.   CELL DEATH AND DIFFERENTIATION

Reduced FHIT expression is associated with tumor progression in sporadic colon adenocarcinoma

(2013) Sanja Kapitanović et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Common chromosome fragile sites in human and murine epithelial cells andFHIT/FRA3Bloss-induced global genome instability

(2013) Seyed Ali Hosseini et al.   GENES CHROMOSOMES & CANCER

ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1

(2013) E. Duplan et al.   JOURNAL OF CELL SCIENCE

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

(2013) Georgia Velimezi et al.   NATURE CELL BIOLOGY

ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

(2013) Valeria Naim et al.   NATURE CELL BIOLOGY

MUS81 promotes common fragile site expression

(2013) Songmin Ying et al.   NATURE CELL BIOLOGY

Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing

(2013) Nicola Crosetto et al.   NATURE METHODS

ATM kinase activity modulates ITCH E3-ubiquitin ligase activity

(2013) S Santini et al.   ONCOGENE

Fhit Delocalizes Annexin A4 from Plasma Membrane to Cytosol and Sensitizes Lung Cancer Cells to Paclitaxel

(2013) Eugenio Gaudio et al.   PLoS One

Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair

(2013) L. Wan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FIGNL1-containing protein complex is required for efficient homologous recombination repair

(2013) J. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-specific endonucleases: guardians of fragile site stability

(2013) Sheroy Minocherhomji et al.   TRENDS IN CELL BIOLOGY

Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy

(2013) Z Salah et al.   Cell Death & Disease

Common Fragile Site Profiling in Epithelial and Erythroid Cells Reveals that Most Recurrent Cancer Deletions Lie in Fragile Sites Hosting Large Genes

(2013) Benoît Le Tallec et al.   Cell Reports

Regulation of Parkin E3 ubiquitin ligase activity

(2012) Helen Walden et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Contribution of germline mutations to PARK2 gene inactivation in lung adenocarcinoma

(2012) Reika Iwakawa et al.   GENES CHROMOSOMES & CANCER

Conditional inactivation of the mouseWwoxtumor suppressor gene recapitulates the null phenotype

(2012) Suhaib K. Abdeen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression

(2012) Joshua C. Saldivar et al.   PLoS Genetics

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

The familial Parkinson Disease gene PARK2 is a multisite tumor suppressor on chromosome 6q25.2-27 that regulates cyclin E

(2011) Selvaraju Veeriah et al.   CELL CYCLE

WW domain-containing proteins: Retrospectives and the future

(2011) Zaidoun Salah   Frontiers in Bioscience-Landmark

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

(2011) Anne Helmrich et al.   MOLECULAR CELL

Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress

(2011) Aygül Dereli-Öz et al.   Molecular Oncology

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

(2011) Anne Letessier et al.   NATURE

Wwox inactivation enhances mammary tumorigenesis

(2011) S K Abdeen et al.   ONCOGENE

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequent Attenuation of the WWOX Tumor Suppressor in Osteosarcoma Is Associated with Increased Tumorigenicity and Aberrant RUNX2 Expression

(2010) K. C. Kurek et al.   CANCER RESEARCH

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

(2010) G. Poulogiannis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fragile gene product, Fhit, in oxidative and replicative stress responses

(2009) Hiroshi Okumura et al.   CANCER SCIENCE

A spontaneous mutation of theWwoxgene and audiogenic seizures in rats with lethal dwarfism and epilepsy

(2009) H. Suzuki et al.   GENES BRAIN AND BEHAVIOR

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

(2009) Selvaraju Veeriah et al.   NATURE GENETICS

Generation and Characterization of Mice Carrying a Conditional Allele of the Wwox Tumor Suppressor Gene

(2009) John H. Ludes-Meyers et al.   PLoS One

Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis

(2009) A. Rimessi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of the DNA damage response in neuronal development, organization and maintenance

(2008) Ari Barzilai et al.   DNA REPAIR

Correlation of Fragile Histidine Triad (Fhit) Protein Structural Features with Effector Interactions and Biological Functions

(2008) Flavia Pichiorri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fhit Interaction with Ferredoxin Reductase Triggers Generation of Reactive Oxygen Species and Apoptosis of Cancer Cells

(2008) Francesco Trapasso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The WWOX Tumor Suppressor Is Essential for Postnatal Survival and Normal Bone Metabolism

(2008) Rami I. Aqeilan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

Human chromosome fragility

(2007) T. Lukusa et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms