The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis

NEK1 Mutations Cause Short-Rib Polydactyly Syndrome Type Majewski

(2011) Christian Thiel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways

(2011) Liyun Sang et al.   CELL

Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR

(2011) Yumay Chen et al.   CELL CYCLE

Ciliary diffusion barrier: The gatekeeper for the primary cilium compartment

(2011) Qicong Hu et al.   Cytoskeleton

Nek1 and TAZ Interact to Maintain Normal Levels of Polycystin 2

(2011) H. Yim et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM)

(2010) Hannah Carter et al.   CANCER BIOLOGY & THERAPY

Polycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarity

(2010) Jingjing Zhang et al.   HUMAN MOLECULAR GENETICS

NPHP proteins: gatekeepers of the ciliary compartment: Figure 1.

(2010) Heymut Omran   JOURNAL OF CELL BIOLOGY

CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content

(2010) Branch Craige et al.   JOURNAL OF CELL BIOLOGY

The cell biology of polycystic kidney disease

(2010) Hannah C. Chapin et al.   JOURNAL OF CELL BIOLOGY

Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy

(2010) E. A. Otto et al.   JOURNAL OF MEDICAL GENETICS

Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP

(2010) John F. Dishinger et al.   NATURE CELL BIOLOGY

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Mechanisms of Nephronophthisis and Related Ciliopathies

(2010) Toby W. Hurd et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Making sense of cilia in disease: The human ciliopathies

(2009) Kate Baker et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Centrioles, Centrosomes, and Cilia in Health and Disease

(2009) Erich A. Nigg et al.   CELL

The Primary Cilium as a Complex Signaling Center

(2009) Nicolas F. Berbari et al.   CURRENT BIOLOGY

Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4

(2009) Jana Mazelova et al.   EMBO JOURNAL

Loss of Oriented Cell Division Does not Initiate Cyst Formation

(2009) S. Nishio et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nephronophthisis: Disease Mechanisms of a Ciliopathy

(2009) F. Hildebrandt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dual and opposing roles of primary cilia in medulloblastoma development

(2009) Young-Goo Han et al.   NATURE MEDICINE

Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis

(2009) Sunny Y Wong et al.   NATURE MEDICINE

The NIMA-family kinase, Nek1 affects the stability of centrosomes and ciliogenesis

(2008) Mark C White et al.   BMC CELL BIOLOGY

The mammalian Nek1 kinase is involved in primary cilium formation

(2008) Ohad Shalom et al.   FEBS LETTERS

The cell biological basis of ciliary disease

(2008) Wallace F. Marshall   JOURNAL OF CELL BIOLOGY

Nek8 Regulates the Expression and Localization of Polycystin-1 and Polycystin-2

(2008) E. Sohara et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NEK8 Mutations Affect Ciliary and Centrosomal Localization and May Cause Nephronophthisis

(2008) E. A. Otto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Defects in ciliary localization of Nek8 is associated with cystogenesis

(2008) Melissa L. Trapp et al.   PEDIATRIC NEPHROLOGY