Systems Genetic Analyses Highlight a TGFβ-FOXO3 Dependent Striatal Astrocyte Network Conserved across Species and Associated with Stress, Sleep, and Huntington’s Disease

Sleep deficits but no metabolic deficits in premanifest Huntington's disease

(2015) Alpar S. Lazar et al.   ANNALS OF NEUROLOGY

Network topology and functional connectivity disturbances precede the onset of Huntington’s disease

(2015) Deborah L. Harrington et al.   BRAIN

Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease

(2015) Jong-Min Lee et al.   CELL

Lithium Treatment in Patients With Huntington's Disease and Suicidal Behavior

(2015) Michele Raja et al.   MOVEMENT DISORDERS

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington’s Disease Neural Stem Cells

(2015) Karen L. Ring et al.   Stem Cell Reports

RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression

(2015) Adam Labadorf et al.   PLoS One

A common gene expression signature in Huntington’s disease patient brain regions

(2014) Andreas Neueder et al.   BMC Medical Genomics

Neurogenesis in the Striatum of the Adult Human Brain

(2014) Aurélie Ernst et al.   CELL

Deep Brain Stimulation: Are Astrocytes a Key Driver Behind the Scene?

(2014) Albert J. Fenoy et al.   CNS Neuroscience & Therapeutics

Preclinical and Clinical Investigations of Mood Stabilizers for Huntington's Disease: What Have We Learned?

(2014) Lisa Scheuing et al.   International Journal of Biological Sciences

A Large Scale Huntingtin Protein Interaction Network Implicates Rho GTPase Signaling Pathways in Huntington Disease

(2014) Cendrine Tourette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons

(2014) Mahesh Kandasamy et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Quadruple deep brain stimulation in Huntington’s disease, targeting pallidum and subthalamic nucleus: case report and review of the literature

(2014) D. Gruber et al.   JOURNAL OF NEURAL TRANSMISSION

Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases

(2014) M. Narayanan et al.   Molecular Systems Biology

Cerebellar abnormalities in Huntington's disease: A role in motor and psychiatric impairment?

(2014) Elin M. Rees et al.   MOVEMENT DISORDERS

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

(2014) Xiaoping Tong et al.   NATURE NEUROSCIENCE

Huntington disease: natural history, biomarkers and prospects for therapeutics

(2014) Christopher A. Ross et al.   Nature Reviews Neurology

The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity

(2014) Cendrine Tourette et al.   PLOS BIOLOGY

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease

(2013) Han-Yun Hsiao et al.   HUMAN MOLECULAR GENETICS

Glutathione peroxidase activity is neuroprotective in models of Huntington's disease

(2013) Robert P Mason et al.   NATURE GENETICS

The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse

(2013) Judith A. Blake et al.   NUCLEIC ACIDS RESEARCH

Striatal Molecular Signature of Subchronic Subthalamic Nucleus High Frequency Stimulation in Parkinsonian Rat

(2013) Sylviane Lortet et al.   PLoS One

Pathways to decoding the clinical potential of stress response FOXO-interaction networks for Huntington's disease: of gene prioritization and context dependence

(2013) Frédéric Parmentier et al.   Frontiers in Aging Neuroscience

oPOSSUM-3: Advanced Analysis of Regulatory Motif Over-Representation Across Genes or ChIP-Seq Datasets

(2013) Andrew T. Kwon et al.   G3-Genes Genomes Genetics

Huntington's Disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database

(2012) Ravi Kiran Reddy Kalathur et al.   BMC Neurology

Degeneration of the Cerebellum in Huntington's Disease (HD): Possible Relevance for the Clinical Picture and Potential Gateway to Pathological Mechanisms of the Disease Process

(2012) Udo Rüb et al.   BRAIN PATHOLOGY

Circadian and sleep disorder in Huntington's disease

(2012) A. Jennifer Morton   EXPERIMENTAL NEUROLOGY

Expression of constitutively active FoxO3 in murine forebrain leads to a loss of neural progenitors

(2012) Uta Schmidt-Strassburger et al.   FASEB JOURNAL

Efficient key pathway mining: combining networks and OMICS data

(2012) Nicolas Alcaraz et al.   Integrative Biology

LTBPs, more than just an escort service

(2012) Vesna Todorovic et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nucleobindin 1 Caps Human Islet Amyloid Polypeptide Protofibrils to Prevent Amyloid Fibril Formation

(2012) Ruchi Gupta et al.   JOURNAL OF MOLECULAR BIOLOGY

Integration of  -Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity

(2012) J. A. Parker et al.   JOURNAL OF NEUROSCIENCE

Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers

(2012) I.-M. Wang et al.   Molecular Systems Biology

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

(2012) Dyna I. Shirasaki et al.   NEURON

Role and Therapeutic Potential of the Pro-Longevity Factor FOXO and Its Regulators in Neurodegenerative Disease

(2012) Christian Neri   Frontiers in Pharmacology

Astrocyte-Derived Adenosine and A1 Receptor Activity Contribute to Sleep Loss-Induced Deficits in Hippocampal Synaptic Plasticity and Memory in Mice

(2011) C. Florian et al.   JOURNAL OF NEUROSCIENCE

Deep brain stimulation and the role of astrocytes

(2011) V Vedam-Mai et al.   MOLECULAR PSYCHIATRY

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

(2011) Mali Jiang et al.   NATURE MEDICINE

Is My Network Module Preserved and Reproducible?

(2011) Peter Langfelder et al.   PLoS Computational Biology

DAF-16/Forkhead Box O Transcription Factor: Many Paths to a Single Fork(head) in the Road

(2010) Kelvin Yen et al.   ANTIOXIDANTS & REDOX SIGNALING

Asymptomatic Sleep Abnormalities Are a Common Early Feature in Patients with Huntington’s Disease

(2010) Anna O. G. Goodman et al.   Current Neurology and Neuroscience Reports

TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

(2010) Kazuhito Naka et al.   NATURE

Discovering causal signaling pathways through gene-expression patterns

(2010) Jignesh R. Parikh et al.   NUCLEIC ACIDS RESEARCH

Reactome: a database of reactions, pathways and biological processes

(2010) D. Croft et al.   NUCLEIC ACIDS RESEARCH

Sleep and circadian rhythm alterations correlate with depression and cognitive impairment in Huntington's disease

(2010) N. Ahmad Aziz et al.   PARKINSONISM & RELATED DISORDERS

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Earliest functional declines in Huntington disease

(2010) Leigh J. Beglinger et al.   PSYCHIATRY RESEARCH

FoxO3 Regulates Neural Stem Cell Homeostasis

(2009) Valérie M. Renault et al.   Cell Stem Cell

Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss

(2009) Michael M. Halassa et al.   NEURON

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

(2009) Jennifer Bradford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo

(2009) T. Fellin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Risperidone and the Treatment of Psychiatric, Motor, and Cognitive Symptoms in Huntington's Disease

(2008) Kevin Duff et al.   Annals of Clinical Psychiatry

Rapid Eye Movement Sleep Disturbances in Huntington Disease

(2008) Isabelle Arnulf et al.   ARCHIVES OF NEUROLOGY

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks

(2008) Jun Zhu et al.   NATURE GENETICS

The PAZAR database of gene regulatory information coupled to the ORCA toolkit for the study of regulatory sequences

(2008) Elodie Portales-Casamar et al.   NUCLEIC ACIDS RESEARCH

HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function

(2008) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of Huntington's disease decades before diagnosis: the Predict-HD study

(2007) J S Paulsen et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling

(2007) Min-Huei Liang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE