A common gene expression signature in Huntington’s disease patient brain regions

Molecular mechanisms linking neuroinflammation and neurodegeneration in MS

(2014) Erik Ellwardt et al.   EXPERIMENTAL NEUROLOGY

Contesting the dogma of an age-related heat shock response impairment: implications for cardiac-specific age-related disorders

(2014) Alisia Carnemolla et al.   HUMAN MOLECULAR GENETICS

Prospects for neuroprotective therapies in prodromal Huntington's disease

(2014) Abhishek Chandra et al.   MOVEMENT DISORDERS

Huntington's disease is a four-repeat tauopathy with tau nuclear rods

(2014) Marta Fernández-Nogales et al.   NATURE MEDICINE

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

(2014) Andrea Crotti et al.   NATURE NEUROSCIENCE

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

(2014) Xiaoping Tong et al.   NATURE NEUROSCIENCE

Protein aggregation and prionopathies

(2014) M. Renner et al.   PATHOLOGIE BIOLOGIE

Parkin and PINK1: much more than mitophagy

(2014) Leslie A. Scarffe et al.   TRENDS IN NEUROSCIENCES

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

The role of inflammation in sporadic and familial Parkinson’s disease

(2013) Michela Deleidi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Novel Immunomodulatory Approaches for the Management of Multiple Sclerosis

(2013) O H Kantarci et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Intranuclear Aggregation of Mutant FUS/TLS as a Molecular Pathomechanism of Amyotrophic Lateral Sclerosis

(2013) Takao Nomura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Choosing an animal model for the study of Huntington's disease

(2013) Mahmoud A. Pouladi et al.   NATURE REVIEWS NEUROSCIENCE

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

When Is Hub Gene Selection Better than Standard Meta-Analysis?

(2013) Peter Langfelder et al.   PLoS One

Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the R6/2 Mouse Model of HD

(2013) Ivan Rattray et al.   PLoS One

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

(2013) K. Sathasivam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntington's disease: underlying molecular mechanisms and emerging concepts

(2013) John Labbadia et al.   TRENDS IN BIOCHEMICAL SCIENCES

An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis

(2013) Melissa S. Rotunno et al.   Frontiers in Cellular Neuroscience

Selection of novel reference genes for use in the human central nervous system: a BrainNet Europe Study

(2012) Pascal F. Durrenberger et al.   ACTA NEUROPATHOLOGICA

GO-Elite: a flexible solution for pathway and ontology over-representation

(2012) Alexander C. Zambon et al.   BIOINFORMATICS

Network methods for describing sample relationships in genomic datasets: application to Huntington’s disease

(2012) Michael C Oldham et al.   BMC Systems Biology

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

(2012) Rene L. Vidal et al.   HUMAN MOLECULAR GENETICS

Activation of Elk-1 participates as a neuroprotective compensatory mechanism in models of Huntington’s disease

(2012) Marta Anglada-Huguet et al.   JOURNAL OF NEUROCHEMISTRY

Gene expression profiling in human neurodegenerative disease

(2012) Johnathan Cooper-Knock et al.   Nature Reviews Neurology

ArrayExpress update—trends in database growth and links to data analysis tools

(2012) Gabriella Rustici et al.   NUCLEIC ACIDS RESEARCH

NCBI GEO: archive for functional genomics data sets—update

(2012) Tanya Barrett et al.   NUCLEIC ACIDS RESEARCH

Strategies for aggregating gene expression data: The collapseRows R function

(2011) Jeremy A Miller et al.   BMC BIOINFORMATICS

Light and electron microscopic characterization of the evolution of cellular pathology in the Hdh(CAG)150 Huntington's disease knock-in mouse

(2011) Zubeyde Bayram-Weston et al.   BRAIN RESEARCH BULLETIN

Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative

(2011) Elisa Fossale et al.   HUMAN MOLECULAR GENETICS

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

(2011) John Labbadia et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of immunity in Huntington's disease

(2011) D Soulet et al.   MOLECULAR PSYCHIATRY

An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity

(2011) Weirui Guo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Is My Network Module Preserved and Reproducible?

(2011) Peter Langfelder et al.   PLoS Computational Biology

Differences in aberrant expression and splicing of sarcomeric proteins in the myotonic dystrophies DM1 and DM2

(2010) Anna Vihola et al.   ACTA NEUROPATHOLOGICA

Metallothioneins and copper metabolism are candidate therapeutic targets in Huntington's disease

(2010) Sarah L. Hands et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT

(2010) Naoki Hayashida et al.   EMBO JOURNAL

Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis

(2010) K. Becanovic et al.   HUMAN MOLECULAR GENETICS

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways

(2010) Jeremy A. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First-generation vs second-generation antipsychotic drugs: The ongoing saga

(2010) Sumeet Gupta   Indian Journal of Psychiatry

Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients

(2009) Christiaan GJ Saris et al.   BMC GENOMICS

Turning REST/NRSF Dysfunction in Huntingtons Disease into a Pharmaceutical Target

(2009) Dorotea Rigamonti et al.   CURRENT PHARMACEUTICAL DESIGN

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Huntington disease: pathogenesis, biomarkers, and approaches to experimental therapeutics

(2009) Christopher A. Ross et al.   PARKINSONISM & RELATED DISORDERS

The Expanding Family of Glioneuronal Tumors

(2008) Daniela S. Allende et al.   ADVANCES IN ANATOMIC PATHOLOGY

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursors

(2008) Jana Fassunke et al.   BRAIN

Implication of the JNK pathway in a rat model of Huntington's disease

(2008) V. Perrin et al.   EXPERIMENTAL NEUROLOGY

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

(2008) Maria Björkqvist et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Huntingtin Modulates Transcription, Occupies Gene Promoters In Vivo, and Binds Directly to DNA in a Polyglutamine-Dependent Manner

(2008) C. L. Benn et al.   JOURNAL OF NEUROSCIENCE

A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging

(2008) J. A. Miller et al.   JOURNAL OF NEUROSCIENCE

A Large Number of Protein Expression Changes Occur Early in Life and Precede Phenotype Onset in a Mouse Model for Huntington Disease

(2008) Claus Zabel et al.   MOLECULAR & CELLULAR PROTEOMICS

Functional organization of the transcriptome in human brain

(2008) Michael C Oldham et al.   NATURE NEUROSCIENCE