Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCγ, PKC, and PI3K/Akt pathways during colitis

BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation

(2015) Xu Ding et al.   NEUROBIOLOGY OF DISEASE

Ht31 peptide inhibited inflammatory pain by blocking NMDA receptor-mediated nociceptive transmission in spinal dorsal horn of mice

(2015) Wen-Tao Wang et al.   NEUROPHARMACOLOGY

Sensitization of nociceptive spinal neurons contributes to pain in a transgenic model of sickle cell disease

(2015) Giuseppe Cataldo et al.   PAIN

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Endogenous PI3K/Akt and NMDAR act independently in the regulation of CREB activity in lumbosacral spinal cord in cystitis

(2013) Jarren C. Kay et al.   EXPERIMENTAL NEUROLOGY

BDNF Regulates Atypical PKC at Spinal Synapses to Initiate and Maintain a Centralized Chronic Pain State

(2013) Ohannes K Melemedjian et al.   Molecular Pain

PKCγ Receptor Mediates Visceral Nociception and Hyperalgesia following Exposure to PTSD-Like Stress in the Spinal Cord of Rats

(2013) Yu-Qin He et al.   Molecular Pain

Epigenetic regulation of BDNF expression in the primary sensory neurons after peripheral nerve injury: Implications in the development of neuropathic pain

(2013) H. Uchida et al.   NEUROSCIENCE

Neurological and cellular regulation of visceral hypersensitivity induced by chronic stress and colonic inflammation in rats

(2013) J. Chen et al.   NEUROSCIENCE

In Vivo Regulation of Brain-Derived Neurotrophic Factor in Dorsal Root Ganglia Is Mediated by Nerve Growth Factor-Triggered Akt Activation during Cystitis

(2013) Li-Ya Qiao et al.   PLoS One

Up-regulation of brain-derived neurotrophic factor is regulated by extracellular signal-regulated protein kinase 5 and by nerve growth factor retrograde signaling in colonic afferent neurons in colitis

(2012) Sharon J. Yu et al.   EXPERIMENTAL NEUROLOGY

Two Mechanisms Involved in Trigeminal CGRP Release: Implications for Migraine Treatment

(2012) Paul L. Durham et al.   HEADACHE

Nerve injury increases brain-derived neurotrophic factor levels to suppress BK channel activity in primary sensory neurons

(2012) Xue-Hong Cao et al.   JOURNAL OF NEUROCHEMISTRY

Up-regulation of brain-derived neurotrophic factor in primary afferent pathway regulates colon-to-bladder cross-sensitization in rat

(2012) Chun-Mei Xia et al.   Journal of Neuroinflammation

Brain-derived neurotrophic factor modulates N-methyl-D-aspartate receptor activation in a rat model of cancer-induced bone pain

(2012) Li-Na Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Carrageenan Induced Phosphorylation of Akt is Dependent on Neurokinin-1 Expressing Neurons in the Superficial Dorsal Horn

(2012) Jeong IL Choi et al.   Molecular Pain

Brain-derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons

(2011) Julia H. Kim et al.   JOURNAL OF NEUROCHEMISTRY

Spinal Phosphinositide 3-Kinase-Akt-Mammalian Target of Rapamycin Signaling Cascades in Inflammation-Induced Hyperalgesia

(2011) Q. Xu et al.   JOURNAL OF NEUROSCIENCE

Long-Term Potentiation in Spinal Nociceptive Pathways as a Novel Target for Pain Therapy

(2011) Ruth Ruscheweyh et al.   Molecular Pain

Prolonged sympathetic innervation of sensory neurons in rat thoracolumbar dorsal root ganglia during chronic colitis

(2011) C.-M. Xia et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation

(2010) Shan-Jing Geng et al.   EXPERIMENTAL NEUROLOGY

Evidence of Central and Peripheral Sensitization in a Rat Model of Narcotic Bowel-Like Syndrome

(2010) Simona Agostini et al.   GASTROENTEROLOGY

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

(2010) Zhen-Zhong Xu et al.   NATURE MEDICINE

Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior

(2010) Jeong Il Choi et al.   PAIN

Colitis induces calcitonin gene-related peptide expression and Akt activation in rat primary afferent pathways

(2009) Li-Ya Qiao et al.   EXPERIMENTAL NEUROLOGY

Activation of TRPV1 Mediates Calcitonin Gene-Related Peptide Release, Which Excites Trigeminal Sensory Neurons and Is Attenuated by a Retargeted Botulinum Toxin with Anti-Nociceptive Potential

(2009) J. Meng et al.   JOURNAL OF NEUROSCIENCE

Memory and the NMDA Receptors

(2009) Fei Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Focus on the Role of Glutamate in the Pathology of the Peripheral Nervous System

(2008) Valentina Carozzi et al.   CNS & Neurological Disorders-Drug Targets

BDNF Modulation of NMDA Receptors Is Activity Dependent

(2008) Robert A. Crozier et al.   JOURNAL OF NEUROPHYSIOLOGY

Bradykinin Enhances AMPA and NMDA Receptor Activity in Spinal Cord Dorsal Horn Neurons by Activating Multiple Kinases to Produce Pain Hypersensitivity

(2008) T. Kohno et al.   JOURNAL OF NEUROSCIENCE

Phosphatidylinositol 3-Kinase Is a Key Mediator of Central Sensitization in Painful Inflammatory Conditions

(2008) S. Pezet et al.   JOURNAL OF NEUROSCIENCE

TRPV2 Is Activated by Cannabidiol and Mediates CGRP Release in Cultured Rat Dorsal Root Ganglion Neurons

(2008) N. Qin et al.   JOURNAL OF NEUROSCIENCE

Differential changes in brain-derived neurotrophic factor and extracellular signal-regulated kinase in rat primary afferent pathways with colitis

(2008) l.-y. qiao et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Effect of cytokines on neuronal excitability

(2008) Maria Schäfers et al.   NEUROSCIENCE LETTERS