Is Axonal Degeneration a Key Early Event in Parkinson’s Disease?

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

(2016) Josiah Gerdts et al.   NEURON

Retrograde Axonal Degeneration in Parkinson Disease

(2016) Patricia Tagliaferro et al.   Journal of Parkinsons Disease

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

(2015) Ariadna Laguna et al.   NATURE NEUROSCIENCE

Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease

(2015) Ulrika Nordström et al.   NEUROBIOLOGY OF DISEASE

An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease

(2015) Patricia Tagliaferro et al.   NEUROBIOLOGY OF DISEASE

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

Engrailed Homeoprotein Protects Mesencephalic Dopaminergic Neurons from Oxidative Stress

(2015) Hocine Rekaik et al.   Cell Reports

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons

(2013) B. Kadkhodaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alterations in axonal transport motor proteins in sporadic and experimental Parkinson’s disease

(2012) Yaping Chu et al.   BRAIN

Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of  -Synuclein and LRRK2 in the Brain

(2012) L. G. Friedman et al.   JOURNAL OF NEUROSCIENCE

Engrailed homeoprotein recruits the adenosine A1 receptor to potentiate ephrin A5 function in retinal growth cones

(2011) O. Stettler et al.   DEVELOPMENT

Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults

(2011) Daniel Alvarez-Fischer et al.   NATURE NEUROSCIENCE

Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons

(2011) M. Decressac et al.   NEUROBIOLOGY OF DISEASE

Age-specific progression of nigrostriatal dysfunction in Parkinson's disease

(2010) Raúl de la Fuente-Fernández et al.   ANNALS OF NEUROLOGY

Bioactivity of AAV2-neurturin gene therapy (CERE-120): Differences between Parkinson's disease and nonhuman primate brains

(2010) Raymond T. Bartus et al.   MOVEMENT DISORDERS

Dopamine turnover increases in asymptomatic LRRK2 mutations carriers

(2010) Vesna Sossi et al.   MOVEMENT DISORDERS

Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV  -Synucleinopathy

(2009) C. Y. Chung et al.   JOURNAL OF NEUROSCIENCE

Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

(2009) Yanping Li et al.   NATURE NEUROSCIENCE

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience