A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015) Theo Vos et al.   LANCET

Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy

(2015) Carlos A. Morillo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Usefulness of real time PCR to quantify parasite load in serum samples from chronic Chagas disease patients

(2015) Myllena F Melo et al.   Parasites & Vectors

Expression, purification, immunogenicity, and protective efficacy of a recombinant Tc24 antigen as a vaccine against Trypanosoma cruzi infection in mice

(2015) Viridiana Martinez-Campos et al.   VACCINE

A Human Type 5 Adenovirus-Based Trypanosoma cruzi Therapeutic Vaccine Re-programs Immune Response and Reverses Chronic Cardiomyopathy

(2015) Isabela Resende Pereira et al.   PLoS Pathogens

A Two-Component DNA-Prime/Protein-Boost Vaccination Strategy for Eliciting Long-Term, Protective T Cell Immunity against Trypanosoma cruzi

(2015) Shivali Gupta et al.   PLoS Pathogens

Time course study of the antigen-specific immune response to a PLGA microparticle vaccine formulation

(2014) Qian Wang et al.   BIOMATERIALS

New, Combined, and Reduced Dosing Treatment Protocols Cure Trypanosoma cruzi Infection in Mice

(2013) J. M. Bustamante et al.   JOURNAL OF INFECTIOUS DISEASES

Global economic burden of Chagas disease: a computational simulation model

(2013) Bruce Y Lee et al.   LANCET INFECTIOUS DISEASES

PLGA nanoparticles loaded with KMP-11 stimulate innate immunity and induce the killing of Leishmania

(2013) Diego M. Santos et al.   Nanomedicine-Nanotechnology Biology and Medicine

TcVac3 Induced Control of Trypanosoma cruzi Infection and Chronic Myocarditis in Mice

(2013) Shivali Gupta et al.   PLoS One

Real-time PCR strategy for parasite quantification in blood and tissue samples of experimental Trypanosoma cruzi infection

(2012) Sérgio Caldas et al.   ACTA TROPICA

Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects

(2012) Eric Dumonteil et al.   Expert Review of Vaccines

Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains

(2012) Sabrina Cencig et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Delivery of antigenic candidates by a DNA/MVA heterologous approach elicits effector CD8+T cell mediated immunity against Trypanosoma cruzi

(2012) Shivali Gupta et al.   VACCINE

Modeling the economic value of a Chagas’ disease therapeutic vaccine

(2012) Bruce Y. Lee et al.   Human Vaccines & Immunotherapeutics

Chagas Disease in Non-Endemic Countries: Epidemiology, Clinical Presentation and Treatment

(2012) José A. Pérez-Molina et al.   Current Infectious Disease Reports

Targeting of Toll-like receptors: a decade of progress in combating infectious diseases

(2011) Mona Hedayat et al.   LANCET INFECTIOUS DISEASES

Parasitic Loads in Tissues of Mice Infected with Trypanosoma cruzi and Treated with AmBisome

(2011) Sabrina Cencig et al.   PLoS Neglected Tropical Diseases

Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses

(2010) Moses O Oyewumi et al.   Expert Review of Vaccines

A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease

(2010) Bianca P. Olivieri et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Chagas disease

(2010) Anis Rassi et al.   LANCET

Effect of a combination DNA vaccine for the prevention and therapy of Trypanosoma cruzi infection in mice: Role of CD4+ and CD8+ T cells

(2010) Alberto Yairh Limon-Flores et al.   VACCINE

Prophylactic Efficacy of TcVac2 against Trypanosoma cruzi in Mice

(2010) Shivali Gupta et al.   PLoS Neglected Tropical Diseases

Innovative strategies for co-delivering antigens and CpG oligonucleotides

(2009) Yogita Krishnamachari et al.   ADVANCED DRUG DELIVERY REVIEWS

Current advances in research and clinical applications of PLGA-based nanotechnology

(2009) Jian-Ming Lü et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

The optimization of TaqMan real-time RT-PCR assay for transcriptional profiling of GABA-A receptor subunit plasticity

(2009) Omkaram Gangisetty et al.   JOURNAL OF NEUROSCIENCE METHODS

Chagas heart disease: pathophysiologic mechanisms, prognostic factors and risk stratification

(2009) Anis Rassi Jr et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

The potency of the adjuvant, CpG oligos, is enhanced by encapsulation in PLG microparticles

(2007) Padma Malyala et al.   JOURNAL OF PHARMACEUTICAL SCIENCES