A Human Type 5 Adenovirus-Based Trypanosoma cruzi Therapeutic Vaccine Re-programs Immune Response and Reverses Chronic Cardiomyopathy

Tumor Necrosis Factor Is a Therapeutic Target for Immunological Unbalance and Cardiac Abnormalities in Chronic Experimental Chagas’ Heart Disease

(2014) Isabela Resende Pereira et al.   MEDIATORS OF INFLAMMATION

Severity of chronic experimental Chagas' heart disease parallels tumour necrosis factor and nitric oxide levels in the serum: models of mild and severe disease

(2014) Isabela Resende Pereira et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Efficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine

(2013) Scott M. Hammer et al.   NEW ENGLAND JOURNAL OF MEDICINE

TcVac3 Induced Control of Trypanosoma cruzi Infection and Chronic Myocarditis in Mice

(2013) Shivali Gupta et al.   PLoS One

Vaccination Using Recombinants Influenza and Adenoviruses Encoding Amastigote Surface Protein-2 Are Highly Effective on Protection against Trypanosoma cruzi Infection

(2013) Rafael Polidoro Alves Barbosa et al.   PLoS One

A Human Type 5 Adenovirus-Based Tuberculosis Vaccine Induces Robust T Cell Responses in Humans Despite Preexisting Anti-Adenovirus Immunity

(2013) F. Smaill et al.   Science Translational Medicine

Trypanosoma cruzi-induced depressive-like behavior is independent of meningoencephalitis but responsive to parasiticide and TNF-targeted therapeutic interventions

(2012) Glaucia Vilar-Pereira et al.   BRAIN BEHAVIOR AND IMMUNITY

Modeling the economic value of a Chagas’ disease therapeutic vaccine

(2012) Bruce Y. Lee et al.   Human Vaccines & Immunotherapeutics

Inducible Nitric Oxide Synthase in Heart Tissue and Nitric Oxide in Serum of Trypanosoma cruzi-Infected Rhesus Monkeys: Association with Heart Injury

(2012) Cristiano Marcelo Espinola Carvalho et al.   PLoS Neglected Tropical Diseases

CD8+ T-Cells Expressing Interferon Gamma or Perforin Play Antagonistic Roles in Heart Injury in Experimental Trypanosoma Cruzi-Elicited Cardiomyopathy

(2012) Jaline Coutinho Silverio et al.   PLoS Pathogens

Pathogen-Induced Proapoptotic Phenotype and High CD95 (Fas) Expression Accompany a Suboptimal CD8+ T-Cell Response: Reversal by Adenoviral Vaccine

(2012) José Ronnie Vasconcelos et al.   PLoS Pathogens

Tumour necrosis factor (TNF)-mediated NF-κB activation facilitates cellular invasion of non-professional phagocytic epithelial cell lines by Trypanosoma cruzi

(2011) Andrea M. T. Pinto et al.   CELLULAR MICROBIOLOGY

ECG scar quantification correlates with cardiac magnetic resonance scar size and prognostic factors in Chagas' disease

(2011) D. G. Strauss et al.   HEART

Advances and challenges towards a vaccine against Chagas disease

(2011) Israel Quijano-Hernandez et al.   Human vaccines & immunotherapeutics

Heterologous Plasmid DNA Prime-Recombinant Human Adenovirus 5 Boost Vaccination Generates a Stable Pool of Protective Long-Lived CD8+T Effector Memory Cells Specific for a Human Parasite, Trypanosoma cruzi

(2011) Paula Ordonhez Rigato et al.   INFECTION AND IMMUNITY

The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications

(2011) Bianca Zingales et al.   INFECTION GENETICS AND EVOLUTION

Adenovirus-5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part B: Safety, Immunogenicity and Protective Efficacy of the CSP Component

(2011) Cindy Tamminga et al.   PLoS One

Biological and immunological characterization of recombinant Yellow Fever 17D Viruses expressing a Trypanosoma cruzi Amastigote Surface Protein-2 CD8+ T cell epitope at two distinct regions of the genome

(2011) Raquel T Nogueira et al.   Virology Journal

The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease

(2010) Caroline Junqueira et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Chagas disease

(2010) Anis Rassi et al.   LANCET

Gap junction reduction in cardiomyocytes following transforming growth factor-β treatment and Trypanosoma cruzi infection

(2010) Mariana C Waghabi et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

The Centennial of the Discovery of Chagas Disease: Facing the Current Challenges

(2010) Joseli Lannes-Vieira et al.   PLoS Neglected Tropical Diseases

Rapamycin: could it enhance vaccine efficacy?

(2009) Jae-Hwan Nam   Expert Review of Vaccines

Vaccination approaches againstTrypanosoma cruziinfection

(2009) Silvia Inés Cazorla et al.   Expert Review of Vaccines

Perforin and Gamma Interferon Expression Are Required for CD4+ and CD8+ T-Cell-Dependent Protective Immunity against a Human Parasite, Trypanosoma cruzi, Elicited by Heterologous Plasmid DNA Prime-Recombinant Adenovirus 5 Boost Vaccination

(2009) B. C. G. de Alencar et al.   INFECTION AND IMMUNITY

Protective immunity against Trypanosoma cruzi

(2009) Cecilia Parodi et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Strain-specific protective immunity following vaccination against experimental Trypanosoma cruzi infection

(2009) Filipe A. Haolla et al.   VACCINE

Relationship between CD107a expression and cytotoxic activity

(2008) Esin Aktas et al.   CELLULAR IMMUNOLOGY

Treatment of chronically Trypanosoma cruzi-infected mice with a CCR1/CCR5 antagonist (Met-RANTES) results in amelioration of cardiac tissue damage

(2008) Gabriela A. Medeiros et al.   MICROBES AND INFECTION

Trypanosoma cruzi infection from the view of CD8+ T cell immunity — An infection model for developing T cell vaccine

(2007) Yasushi Miyahira   PARASITOLOGY INTERNATIONAL