Review
Cell Biology
Corinne Grey, Bernard de Massy
Summary: The axial element plays a crucial role in establishing sister chromatid cohesion and meiotic recombination during prophase I of meiosis, contributing to the successful outcome of meiosis I.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
James E. Collier, Kim A. Nasmyth
Summary: The ring model proposes that sister chromatid cohesion is mediated by the entrapment of sister DNAs inside a cohesin ring. Previous studies have only tested this model using small circular mini-chromosomes in yeast. In this study, the researchers demonstrate that cohesin possesses two DNA gates, one at the Smc3/Scc1 interface and a second at the Smc1/3 hinge. Passage of DNAs through the hinge is essential for building sister chromatid cohesion, while passage through the Smc3/Scc1 interface is necessary for cohesin's release from chromosomes.
Article
Biochemistry & Molecular Biology
Yongliang Shang, Ju Huang, Weidong Li, Yanan Zhang, Xu Zhou, Qiqi Shao, Taicong Tan, Shen Yin, Liangran Zhang, Shunxin Wang
Summary: MEIOK21 plays important roles in regulating female meiosis and the number and quality of oocytes. Lack of MEIOK21 leads to a decrease in oocyte number, poor oocyte quality, and defects in meiotic recombination and crossover maturation.
Article
Plant Sciences
Chiara Di Dio, Heidi Serra, Pierre Sourdille, James D. Higgins
Summary: During meiosis, ASYNAPSIS 1 (ASY1) promotes inter-homolog recombination, synapsis, and crossover formation. Decreased chiasmata and delayed meiotic prophase I progression were observed in asy1 hypomorphic mutants, while asy1 null mutants showed arrested development. On the other hand, the ectopic recombination between non-homologous chromosomes increased in these mutants. Therefore, asy1 mutants can be used to enhance recombination between wheat wild relatives and elite varieties for accelerating the introgression of important agronomic traits.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yulia Gryaznova, Leonor Keating, Sandra A. Touati, Damien Cladiere, Warif El Yakoubi, Eulalie Buffin, Katja Wassmann
Summary: This research explores the separation of sister kinetochores and removal of cohesin during meiosis, revealing that the initial separation of sister kinetochores actually occurs during meiosis I, not meiosis II as previously thought. This indicates that whether centromeric cohesin is removed or not is determined by the kinetochore structure prior to meiosis II.
Article
Cell Biology
Roberto de la Fuente, Florencia Pratto, Abrahan Hernandez-Hernandez, Marcia Manterola, Pablo Lopez-Jimenez, Rocio Gomez, Alberto Viera, Maria Teresa Parra, Anna Kouznetsova, R. Daniel Camerini-Otero, Jesus Page
Summary: This study investigates the impact of disruptions in recombination and synapsis on the dynamics of epigenetic markers and transcriptional regulation during meiosis in knockout mice. Results show that impairment of recombination and synapsis alters the epigenetic marks and transcriptional regulation, suggesting a crucial role in the impairment of meiosis progression in mammals.
Review
Cell Biology
Funda M. Kar, Andreas Hochwagen
Summary: Germ cells rely on a complex network of surveillance mechanisms to ensure the production of euploid gametes during meiosis. Dynamic protein phosphorylation, controlled by kinases and phosphatases, plays a crucial role in regulating chromosomal and cellular behavior throughout meiotic prophase. This review discusses common principles and detailed examples of how phosphorylation events are utilized to ensure faithful passage of chromosomes from one generation to the next.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yukiko Imai, Kenji Saito, Kazumasa Takemoto, Fabien Velilla, Toshihiro Kawasaki, Kei-ichiro Ishiguro, Noriyoshi Sakai
Summary: The mutation in the zebrafish gene encoding the transverse filament protein Sycp1 leads to incomplete pairing of homologs in zebrafish meiosis, while not affecting double-strand break formation near telomeres.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hao Yu, Liping Zhang, Xiaojuan He, Taohui Zhang, Chaolong Wang, Jiayu Lu, Xiaodong He, Keyi Chen, Weihang Gu, Siqi Cheng, Yang Hu, Bowen Yao, Anqi Jian, Xiaowen Yu, Hai Zheng, Shimin You, Qiming Wang, Dekun Lei, Ling Jiang, Zhigang Zhao, Jianmin Wan
Summary: This study identified a gene, OsPHS1, in rice that is involved in homologous chromosome recognition and pairing during meiosis. Mutations in OsPHS1 resulted in abnormal development of pollen and embryo sacs, leading to male and female sterility in rice plants. The findings suggest that OsPHS1 plays a crucial role in homologous chromosome pairing during rice gametogenesis.
Article
Cell Biology
Wei Ma, Jingwen Zhou, Jian Chen, Antony M. Carr, Yoshinori Watanabe
Summary: The study elucidates the molecular mechanisms of Moa1 in regulating centromeric cohesion protection by associating with Plo1 kinase to control Rec8 phosphorylation, enhancing the activity of PP2A associated with Sgo1, and preventing the cleavage of Rec8 by separase through dephosphorylation at another site.
GENES & DEVELOPMENT
(2021)
Review
Biochemistry & Molecular Biology
Avi Matityahu, Itay Onn
Summary: This article reviews the history of the debate on cohesin stoichiometry and summarizes the central evidence for cohesin activity as a monomer or an oligomer. The possible biological significance of cohesin oligomerization and unanswered questions are discussed.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Cell Biology
F. Javier Valero-Regalon, Mireia Sole, Pablo Lopez-Jimenez, Maria Valerio-de Arana, Marta Martin-Ruiz, Roberto de la Fuente, Laia Marin-Gual, Marilyn B. B. Renfree, Geoff Shaw, Soledad Berrios, Raul Fernandez-Donoso, Paul D. D. Waters, Aurora Ruiz-Herrera, Rocio Gomez, Jesus Page
Summary: In eutherian mammals, hundreds of programmed DNA double-strand breaks (DSBs) are generated at the onset of meiosis. Recent findings have revealed different patterns of DNA damage signaling and repair in marsupial mammals. This study analyzed synapsis and the chromosomal distribution of meiotic DSBs markers in three different marsupial species and found inter-specific differences and association with synapsis patterns. These results suggest that there is likely an ancestral pattern of meiotic features in marsupials and a shift occurred after the split of certain species.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Reproductive Biology
M. Bugno-Poniewierska, W. Witarski, M. Kuchta-Gladysz, A. Jakubczak, G. Jezewska-Witkowska
Summary: The study found that male interspecific hybrids of the red fox and the arctic fox exhibit meiotic division abnormalities, characterized by chromosomal pairing anomalies and disrupted meiotic checkpoint signaling, leading to a high percentage of apoptotic cells in the gonads and resulting in sterility.
Article
Cell Biology
Kazi Nazrul Islam, Maitri Mitesh Modi, Kellee Renee Siegfried
Summary: The SMC1β protein plays a crucial role in meiosis in vertebrates, primarily involved in meiosis in both fish and mammals. In zebrafish, Smc1b is essential for the leptotene to zygotene transition in spermatogenesis, with key differences in Smc1b requirement for meiosis observed among vertebrates.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Rachel Beverley, Meredith L. Snook, Miguel Angel Brieno-Enriquez
Summary: Successful human reproduction relies on the well-orchestrated development of competent gametes through the process of meiosis. Cohesin proteins play a crucial role in establishing sister chromatid cohesion, essential for proper DNA repair and chromosome segregation. Failure to replenish cohesin proteins loaded during female fetal life may contribute to age-related aneuploidy in oocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Dideke E. Verver, Grace H. Hwang, Philip W. Jordan, Geert Hamer
Article
Cell Biology
Marina V. Pryzhkova, Philip W. Jordan
JOURNAL OF CELL SCIENCE
(2016)
Article
Multidisciplinary Sciences
Chun Fu, Khurshida Begum, Philip W. Jordan, Yan He, Paul A. Overbeek
Article
Genetics & Heredity
Yi Zheng, Qijing Lei, Aldo Jongejan, Callista L. Mulder, Saskia K. M. van Daalen, Sebastiaan Mastenbroek, Grace Hwang, Philip W. Jordan, Sjoerd Repping, Geert Hamer
Article
Cell & Tissue Engineering
Marina V. Pryzhkova, Philip W. Jordan
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2020)
Article
Cell Biology
Andras Horvath, Gergely Rona, Michele Pagano, Philip W. Jordan
BMC MOLECULAR AND CELL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Thao P. Phan, Aubrey L. Maryniak, Christina A. Boatwright, Junsu Lee, Alisa Atkins, Andrea Tijhuis, Diana C. J. Spierings, Hisham Bazzi, Floris Foijer, Philip W. Jordan, Travis H. Stracker, Andrew J. Holland
Summary: Depletion of centrosome proteins in neural progenitor cells (NPCs) prolongs mitosis and increases TP53-mediated apoptosis in the developing brain. Activation of the mitotic surveillance pathway by mitotic delays is proposed to be the mechanism behind microcephaly caused by mutations in centrosome genes. Loss of 53BP1 or USP28 can rescue cell death after delayed mitosis in NPCs, restoring NPC proliferation and brain size.
Article
Biology
Alisa Atkins, Michelle J. Xu, Maggie Li, Nathaniel P. Rogers, Marina Pryzhkova, Philip W. Jordan
Article
Biochemistry & Molecular Biology
Stephen R. Wellard, Yujiao Zhang, Chris Shults, Xueqi Zhao, Matthew McKay, Stephen A. Murray, Philip W. Jordan
Summary: The study highlights the critical role of centriole duplication, centrosome maturation, and separation in establishing bipolar spindles during meiotic divisions. The findings show that Polo-like kinase 1 and Aurora A kinase are essential for centrosome maturation and separation, and PLK1 is required to inhibit the second round of centriole duplication until late anaphase I to ensure accurate chromosome segregation during spermatogenesis.
Correction
Biochemistry & Molecular Biology
Stephen R. Wellard, Yujiao Zhang, Chris Shults, Xueqi Zhao, Matthew McKay, Stephen A. Murray, Philip W. Jordan
Article
Cell Biology
Thao P. Phan, Christina A. Boatwright, Chelsea G. Drown, Marnie W. Skinner, Margaret A. Strong, Philip W. Jordan, Andrew J. Holland
Summary: This study reveals the translational control of PLK4 through uORFs and its crucial role in preventing centriole amplification and preserving genomic integrity in germ cells. Knockout of Plk4 uORFs leads to reduced fertility and increased mitotic errors in mice, which can be rescued by reducing Plk4 mRNA levels. These findings highlight the importance of uORF-mediated translational suppression of PLK4 in maintaining proper cell division and preventing disease progression.
GENES & DEVELOPMENT
(2022)
Article
Cell & Tissue Engineering
Marina Pryzhkova, Romina Boers, Philip W. Jordan
Summary: This study developed a simple bioreactor-based organoid culture system to model early human gonad development. It provides opportunities for studying the causes of sex development disorders, advancing our understanding of human gonad and germ cell development. Additionally, this technology can be applied to modeling causes of infertility and regenerative medicine applications.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Cell Biology
Stephen R. Wellard, Karen Schindler, Philip W. Jordan
JOURNAL OF CELL SCIENCE
(2020)
Article
Developmental Biology
Grace Hwang, Fengyun Sun, Marilyn O'Brien, John J. Eppig, Mary Ann Handel, Philip W. Jordan
Article
Biochemistry & Molecular Biology
Philip W. Jordan, Craig Eyster, Jingrong Chen, Roberto J. Pezza, Susannah Rankin
CHROMOSOME RESEARCH
(2017)