Resolving complex chromosome structures during meiosis: versatile deployment of Smc5/6

ATPase-Dependent Control of the Mms21 SUMO Ligase during DNA Repair

(2015) Marcelino Bermúdez-López et al.   PLOS BIOLOGY

Self-Organization of Meiotic Recombination Initiation: General Principles and Molecular Pathways

(2014) Scott Keeney et al.   Annual Review of Genetics

The SMC5/6 Complex Is Involved in Crucial Processes During Human Spermatogenesis1

(2014) Dideke E. Verver et al.   BIOLOGY OF REPRODUCTION

Structural Maintenance of Chromosome (SMC) Proteins Link Microtubule Stability to Genome Integrity

(2014) Guillaume Laflamme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance

(2014) Felicity Payne et al.   JOURNAL OF CLINICAL INVESTIGATION

Restriction of Replication Fork Regression Activities by a Conserved SMC Complex

(2014) Xiaoyu Xue et al.   MOLECULAR CELL

The maintenance of chromosome structure: positioning and functioning of SMC complexes

(2014) Kristian Jeppsson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Correction: Mutation of the Mouse Syce1 Gene Disrupts Synapsis and Suggests a Link between Synaptonemal Complex Structural Components and DNA Repair

(2014) Ewelina Bolcun-Filas et al.   PLoS Genetics

The Chromosomal Association of the Smc5/6 Complex Depends on Cohesion and Predicts the Level of Sister Chromatid Entanglement

(2014) Kristian Jeppsson et al.   PLoS Genetics

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

Numerical constraints and feedback control of double-strand breaks in mouse meiosis

(2013) L. Kauppi et al.   GENES & DEVELOPMENT

Dynamic localization of SMC5/6 complex proteins during mammalian meiosis and mitosis suggests functions in distinct chromosome processes

(2013) R. Gomez et al.   JOURNAL OF CELL SCIENCE

Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells

(2013) Lina Marcela Gallego-Paez et al.   MOLECULAR BIOLOGY OF THE CELL

Role for rodent Smc6 in pericentromeric heterochromatin domains during spermatogonial differentiation and meiosis

(2013) D E Verver et al.   Cell Death & Disease

Correction: Combinatorial Regulation of Meiotic Holliday Junction Resolution in C. elegans by HIM-6 (BLM) Helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 Nucleases

(2013) Ana Agostinho et al.   PLoS Genetics

Smc5/6 Coordinates Formation and Resolution of Joint Molecules with Chromosome Morphology to Ensure Meiotic Divisions

(2013) Alice Copsey et al.   PLoS Genetics

Inhibition of the Smc5/6 Complex during Meiosis Perturbs Joint Molecule Formation and Resolution without Significantly Changing Crossover or Non-crossover Levels

(2013) Ingrid Lilienthal et al.   PLoS Genetics

Smc5/6-Mms21 Prevents and Eliminates Inappropriate Recombination Intermediates in Meiosis

(2013) Martin Xaver et al.   PLoS Genetics

Delineation of Joint Molecule Resolution Pathways in Meiosis Identifies a Crossover-Specific Resolvase

(2012) Kseniya Zakharyevich et al.   CELL

Sex chromosome inactivation in germ cells: emerging roles of DNA damage response pathways

(2012) Yosuke Ichijima et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SUMOylation of the α-Kleisin Subunit of Cohesin Is Required for DNA Damage-Induced Cohesion

(2012) Alexandra McAleenan et al.   CURRENT BIOLOGY

The Heterochromatic Barrier to DNA Double Strand Break Repair: How to Get the Entry Visa

(2012) Aaron A. Goodarzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BLM Helicase Ortholog Sgs1 Is a Central Regulator of Meiotic Recombination Intermediate Metabolism

(2012) Arnaud De Muyt et al.   MOLECULAR CELL

Meiotic DNA joint molecule resolution depends on Nse5-Nse6 of the Smc5-Smc6 holocomplex

(2012) S. Wehrkamp-Richter et al.   NUCLEIC ACIDS RESEARCH

The Smc5-Smc6 Complex Regulates Recombination at Centromeric Regions and Affects Kinetochore Protein Sumoylation during Normal Growth

(2012) Vladimir Yong-Gonzales et al.   PLoS One

The Smc complexes in DNA damage response

(2012) Nan Wu et al.   Cell and Bioscience

DNA-binding properties of Smc6, a core component of the Smc5–6 DNA repair complex

(2011) Marc-André Roy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Meiosis-specific gene discovery in plants: RNA-Seq applied to isolated Arabidopsis male meiocytes

(2011) Changbin Chen et al.   BMC PLANT BIOLOGY

Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

(2011) Joao Matos et al.   CELL

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

(2011) Irene Chiolo et al.   CELL

Partners apart: Smc6-independent DNA binding activity of Smc5 on single-strand DNA

(2011) Julien Vignard et al.   CELL CYCLE

Dynamic and selective DNA-binding activity of Smc5, a core component of the Smc5-Smc6 complex

(2011) Marc-André Roy et al.   CELL CYCLE

The SMC complexes, DNA and chromosome topology: right or knot?

(2011) Sidney D. Carter et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The choice in meiosis - defining the factors that influence crossover or non-crossover formation

(2011) J. L. Youds et al.   JOURNAL OF CELL SCIENCE

Roles of Vertebrate Smc5 in Sister Chromatid Cohesion and Homologous Recombinational Repair

(2011) A. K. Stephan et al.   MOLECULAR AND CELLULAR BIOLOGY

Chromosome length influences replication-induced topological stress

(2011) Andreas Kegel et al.   NATURE

The Smc5–Smc6 Complex Is Required to Remove Chromosome Junctions in Meiosis

(2011) Sarah Farmer et al.   PLoS One

A Novel Mouse Synaptonemal Complex Protein Is Essential for Loading of Central Element Proteins, Recombination, and Fertility

(2011) Sabine Schramm et al.   PLoS Genetics

Crossover Invariance Determined by Partner Choice for Meiotic DNA Break Repair

(2010) Randy W. Hyppa et al.   CELL

SMC complexes and topoisomerase II work together so that sister chromatids can work apart

(2010) Claudia Tapia-Alveal et al.   CELL CYCLE

MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases

(2010) Jennifer M. Doyle et al.   MOLECULAR CELL

The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages

(2010) M. Bermudez-Lopez et al.   NUCLEIC ACIDS RESEARCH

Structural Maintenance of Chromosomes (SMC) Proteins Promote Homolog-Independent Recombination Repair in Meiosis Crucial for Germ Cell Genomic Stability

(2010) Jeremy S. Bickel et al.   PLoS Genetics

The unnamed complex: what do we know about Smc5-Smc6?

(2009) Giacomo De Piccoli et al.   CHROMOSOME RESEARCH

The Yin and Yang of the MMS21–SMC5/6 SUMO ligase complex in homologous recombination

(2009) Patrick Ryan Potts   DNA REPAIR

Regulation of rDNA stability by sumoylation

(2009) Nadine Eckert-Boulet et al.   DNA REPAIR

Smc5/6 maintains stalled replication forks in a recombination-competent conformation

(2009) Anja Irmisch et al.   EMBO JOURNAL

Architecture of the Smc5/6 Complex ofSaccharomyces cerevisiaeReveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6

(2009) Xinyuan Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smc5-Smc6-Dependent Removal of Cohesin from Mitotic Chromosomes

(2009) E. A. Outwin et al.   MOLECULAR AND CELLULAR BIOLOGY

The consequences of asynapsis for mammalian meiosis

(2009) Paul S. Burgoyne et al.   NATURE REVIEWS GENETICS

The STRUCTURAL MAINTENANCE OF CHROMOSOMES 5/6 Complex Promotes Sister Chromatid Alignment and Homologous Recombination after DNA Damage in Arabidopsis thaliana

(2009) K. Watanabe et al.   PLANT CELL

Nse1 RING-like Domain Supports Functions of the Smc5-Smc6 Holocomplex in Genome Stability

(2008) Stephanie Pebernard et al.   MOLECULAR BIOLOGY OF THE CELL

RecQ Helicase, Sgs1, and XPF Family Endonuclease, Mus81-Mms4, Resolve Aberrant Joint Molecules during Meiotic Recombination

(2008) Steve D. Oh et al.   MOLECULAR CELL

Mus81/Mms4 Endonuclease and Sgs1 Helicase Collaborate to Ensure Proper Recombination Intermediate Metabolism during Meiosis

(2008) Lea Jessop et al.   MOLECULAR CELL

Expression and functional analysis of AtMUS81 in Arabidopsis meiosis reveals a role in the second pathway of crossing-over

(2008) James D. Higgins et al.   PLANT JOURNAL

MUS81 Generates a Subset of MLH1-MLH3–Independent Crossovers in Mammalian Meiosis

(2008) J. Kim Holloway et al.   PLoS Genetics

Disruption of pairing and synapsis of chromosomes causes stage-specific apoptosis of male meiotic cells

(2007) G. Hamer et al.   THERIOGENOLOGY