Biomaterials in siRNA Delivery: A Comprehensive Review

Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy

(2015) Guosong Hong et al.   CHEMICAL REVIEWS

Cancer nanomedicine: from targeted delivery to combination therapy

(2015) Xiaoyang Xu et al.   TRENDS IN MOLECULAR MEDICINE

Single-Walled Carbon Nanotubes Noncovalently Functionalized with Lipid Modified Polyethylenimine for siRNA Delivery in Vitro and in Vivo

(2014) King S. Siu et al.   BIOCONJUGATE CHEMISTRY

First-in-Human Phase I Study of the Liposomal RNA Interference Therapeutic Atu027 in Patients With Advanced Solid Tumors

(2014) Beate Schultheis et al.   JOURNAL OF CLINICAL ONCOLOGY

Modifications in Small Interfering RNA That Separate Immunostimulation from RNA Interference

(2014) F. Eberle et al.   JOURNAL OF IMMUNOLOGY

Gold Nanoparticles for Nucleic Acid Delivery

(2014) Ya Ding et al.   MOLECULAR THERAPY

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

(2014) Y. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice

(2014) M. Yasuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticle-Mediated Systemic Delivery of siRNA for Treatment of Cancers and Viral Infections

(2014) Mohamed Shehata Draz et al.   Theranostics

Tumor-Targeting Multifunctional Nanoparticles for siRNA Delivery: Recent Advances in Cancer Therapy

(2014) Sook Hee Ku et al.   Advanced Healthcare Materials

Codelivery of an Optimal Drug/siRNA Combination Using Mesoporous Silica Nanoparticles To Overcome Drug Resistance in Breast Cancer in Vitro and in Vivo

(2013) Huan Meng et al.   ACS Nano

Microfluidic Platform for Combinatorial Synthesis and Optimization of Targeted Nanoparticles for Cancer Therapy

(2013) Pedro M. Valencia et al.   ACS Nano

Carbon nanotubes as vectors for gene therapy: Past achievements, present challenges and future goals

(2013) Katie Bates et al.   ADVANCED DRUG DELIVERY REVIEWS

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

(2013) Nicolas Bertrand et al.   ADVANCED DRUG DELIVERY REVIEWS

A review of the current status of siRNA nanomedicines in the treatment of cancer

(2013) Pauline Resnier et al.   BIOMATERIALS

Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery and therapy

(2013) Vasudevanpillai Biju   CHEMICAL SOCIETY REVIEWS

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

(2013) Teresa Coelho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug

(2013) X. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles

(2013) P. L. Rodriguez et al.   SCIENCE

Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma

(2013) S. A. Jensen et al.   Science Translational Medicine

Polyethylene Glycol and Polyethylenimine Dual-Functionalized Nano-Graphene Oxide for Photothermally Enhanced Gene Delivery

(2013) Liangzhu Feng et al.   Small

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

(2013) Josep Tabernero et al.   Cancer Discovery

Advances in Lipid Nanoparticles for siRNA Delivery

(2013) Yuen Tam et al.   Pharmaceutics

Gene Silencing by Gold Nanoshell-Mediated Delivery and Laser-Triggered Release of Antisense Oligonucleotide and siRNA

(2012) Ryan Huschka et al.   ACS Nano

Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine

(2012) Xue-Qing Zhang et al.   ADVANCED DRUG DELIVERY REVIEWS

Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery

(2012) Fangqiong Tang et al.   ADVANCED MATERIALS

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synergistic anticancer effect of RNAi and photothermal therapy mediated by functionalized single-walled carbon nanotubes

(2012) Lei Wang et al.   BIOMATERIALS

Attacking the genome: emerging siRNA nanocarriers from concept to clinic

(2012) Christopher Alabi et al.   CURRENT OPINION IN PHARMACOLOGY

The Blood-Brain/Tumor Barriers: Challenges and Chances for Malignant Gliomas Targeted Drug Delivery

(2012) Changyou Zhan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

siRNA Delivery with Lipid-based Systems: Promises and Pitfalls

(2012) Camilla Foged   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Recent progress in copolymer-mediated siRNA delivery

(2012) Zong-Wei Wu et al.   JOURNAL OF DRUG TARGETING

The preparation of functionalized graphene oxide for targeted intracellular delivery of siRNA

(2012) Xiaoying Yang et al.   JOURNAL OF MATERIALS CHEMISTRY

Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

(2012) Delai Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spherical Nucleic Acids

(2012) Joshua I. Cutler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Action and Reaction: The Biological Response to siRNA and Its Delivery Vehicles

(2012) Rosemary L Kanasty et al.   MOLECULAR THERAPY

Self-assembled RNA interference microsponges for efficient siRNA delivery

(2012) Jong Bum Lee et al.   NATURE MATERIALS

Microfluidic technologies for accelerating the clinical translation of nanoparticles

(2012) Pedro M. Valencia et al.   Nature Nanotechnology

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation

(2012) Dan Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery

(2012) D. N. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remote activation of biomolecules in deep tissues using near-infrared-to-UV upconversion nanotransducers

(2012) M. K. G. Jayakumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

(2012) J. Hrkach et al.   Science Translational Medicine

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells

(2012) Tatiana I Novobrantseva et al.   Molecular Therapy-Nucleic Acids

Systematic Evaluation of Nanomaterial Toxicity: Utility of Standardized Materials and Rapid Assays

(2011) Stacey L. Harper et al.   ACS Nano

Multimodal Nanodiamond Drug Delivery Carriers for Selective Targeting, Imaging, and Enhanced Chemotherapeutic Efficacy

(2011) Xue-Qing Zhang et al.   ADVANCED MATERIALS

Current progress of siRNA/shRNA therapeutics in clinical trials

(2011) John C. Burnett et al.   Biotechnology Journal

Systemic delivery of therapeutic small interfering RNA using a pH-triggered amphiphilic poly-l-lysine nanocarrier to suppress prostate cancer growth in mice

(2011) Jianfeng Guo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery

(2011) L Li et al.   GENE THERAPY

Synthesis and characterization of mannosylated pegylated polyethylenimine as a carrier for siRNA

(2011) NaJung Kim et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

siRNA nanocarriers based on methacrylic acid copolymers

(2011) Arnaud E. Felber et al.   JOURNAL OF CONTROLLED RELEASE

Systemic delivery of siRNA with cationic lipid assisted PEG-PLA nanoparticles for cancer therapy

(2011) Xian-Zhu Yang et al.   JOURNAL OF CONTROLLED RELEASE

Calcium phosphate nanoparticles with an asymmetric lipid bilayer coating for siRNA delivery to the tumor

(2011) Jun Li et al.   JOURNAL OF CONTROLLED RELEASE

The journey of a drug-carrier in the body: An anatomo-physiological perspective

(2011) Nicolas Bertrand et al.   JOURNAL OF CONTROLLED RELEASE

Gene Silencing by siRNA Microhydrogels via Polymeric Nanoscale Condensation

(2011) Cheol Am Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Therapeutic siRNA silencing in inflammatory monocytes in mice

(2011) Florian Leuschner et al.   NATURE BIOTECHNOLOGY

Nanodiamond Therapeutic Delivery Agents Mediate Enhanced Chemoresistant Tumor Treatment

(2011) E. K. Chow et al.   Science Translational Medicine

Enhanced Chemotherapy Efficacy by Sequential Delivery of siRNA and Anticancer Drugs Using PEI-Grafted Graphene Oxide

(2011) Liming Zhang et al.   Small

Tumor delivery of macromolecular drugs based on the EPR effect

(2010) Vladimir Torchilin   ADVANCED DRUG DELIVERY REVIEWS

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Nanoparticle-Based Delivery System for Application of siRNA In Vivo

(2010) Yan Wang et al.   CURRENT DRUG METABOLISM

Nanodiamond Vectors Functionalized with Polyethylenimine for siRNA Delivery

(2010) Mark Chen et al.   Journal of Physical Chemistry Letters

Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

(2010) Thomas W Geisbert et al.   LANCET

Single-wall carbon nanotubes assisted photothermal cancer therapy: Animal study with a murine model of squamous cell carcinoma

(2010) Naiyan Huang et al.   LASERS IN SURGERY AND MEDICINE

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Observation and control of blinking nitrogen-vacancy centres in discrete nanodiamonds

(2010) C. Bradac et al.   Nature Nanotechnology

Error-prone translesion synthesis mediates acquired chemoresistance

(2010) K. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of Rev3, the catalytic subunit of Pol , sensitizes drug-resistant lung tumors to chemotherapy

(2010) J. Doles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Release of 17-β Estradiol from Cationic Polyamidoamine Dendrimer Surface-Modified Poly (Lactic-co-Glycolic Acid) Microparticles Improves Osteogenic Differentiation of Human Mesenchymal Stromal Cells

(2010) Liu Hong et al.   TISSUE ENGINEERING PART C-METHODS

Laser-Activated Gene Silencing via Gold Nanoshell−siRNA Conjugates

(2009) Gary B. Braun et al.   ACS Nano

Impact of Nanotechnology on Drug Delivery

(2009) Omid C. Farokhzad et al.   ACS Nano

Degradable polyethylenimines as DNA and small interfering RNA carriers

(2009) D Jere et al.   Expert Opinion on Drug Delivery

RNA interference screening for the discovery of oncology targets

(2009) Kim Quon et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery

(2009) Jun Li et al.   JOURNAL OF CONTROLLED RELEASE

The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

(2009) Mark E. Davis   MOLECULAR PHARMACEUTICS

Targeted Systemic Delivery of a Therapeutic siRNA with a Multifunctional Carrier Controls Tumor Proliferation in Mice

(2009) Xu-Li Wang et al.   MOLECULAR PHARMACEUTICS

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Gold Nanoparticles Capped with Polyethyleneimine for Enhanced siRNA Delivery

(2009) Wen-Jing Song et al.   Small

Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery

(2008) Monty Liong et al.   ACS Nano

Progress in developing cationic vectors for non-viral systemic gene therapy against cancer

(2008) Marie Morille et al.   BIOMATERIALS

Targeted Delivery of Small Interfering RNA: Approaching Effective Cancer Therapies

(2008) K. F. Pirollo et al.   CANCER RESEARCH

Misinterpreting the Therapeutic Effects of Small Interfering RNA Caused by Immune Stimulation

(2008) Marjorie Robbins et al.   HUMAN GENE THERAPY

Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer

(2008) Sun Hwa Kim et al.   JOURNAL OF CONTROLLED RELEASE

Polyplexes from Poly(aspartamide) Bearing 1,2-Diaminoethane Side Chains Induce pH-Selective, Endosomal Membrane Destabilization with Amplified Transfection and Negligible Cytotoxicity

(2008) Kanjiro Miyata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

Mass production and dynamic imaging of fluorescent nanodiamonds

(2008) Yi-Ren Chang et al.   Nature Nanotechnology

ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity

(2008) A. Okumura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers

(2008) F. Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

(2008) M. Frank-Kamenetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles

(2007) Derek W. Bartlett et al.   BIOTECHNOLOGY AND BIOENGINEERING