Recent progress in copolymer-mediated siRNA delivery

Multifunctional Triblock Nanocarrier (PAMAM-PEG-PLL) for the Efficient Intracellular siRNA Delivery and Gene Silencing

(2011) Mahesh L. Patil et al.   ACS Nano

Traceable Multifunctional Micellar Nanocarriers for Cancer-Targeted Co-delivery of MDR-1 siRNA and Doxorubicin

(2011) Xiao-Bing Xiong et al.   ACS Nano

Using drug-excipient interactions for siRNA delivery

(2011) Katharina Bruno   ADVANCED DRUG DELIVERY REVIEWS

Differentially Charged Hollow Core/Shell Lipid-Polymer-Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery

(2011) Jinjun Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effect of Polymer Structure on Micelles Formed between siRNA and Cationic Block Copolymer Comprising Thiols and Amidines

(2011) R. James Christie et al.   BIOMACROMOLECULES

Synthesis of Folate-Functionalized RAFT Polymers for Targeted siRNA Delivery

(2011) Danielle S. W. Benoit et al.   BIOMACROMOLECULES

Synthesis of Biocompatible PEG-Based Star Polymers with Cationic and Degradable Core for siRNA Delivery

(2011) Hong Y. Cho et al.   BIOMACROMOLECULES

Diblock Glycopolymers Promote Colloidal Stability of Polyplexes and Effective pDNA and siRNA Delivery under Physiological Salt and Serum Conditions

(2011) Adam E. Smith et al.   BIOMACROMOLECULES

Local delivery of siRNA using a biodegradable polymer application to enhance BMP-induced bone formation

(2011) Tomoya Manaka et al.   BIOMATERIALS

Dual mode polyspermine with tunable degradability for plasmid DNA and siRNA delivery

(2011) Min Suk Shim et al.   BIOMATERIALS

A single-monomer derived linear-like PEI-co-PEG for siRNA delivery and silencing

(2011) Lin-Ren Tsai et al.   BIOMATERIALS

Structural contributions of blocked or grafted poly(2-dimethylaminoethyl methacrylate) on PEGylated polycaprolactone nanoparticles in siRNA delivery

(2011) Daoshu Lin et al.   BIOMATERIALS

Co-delivery of small interfering RNA and plasmid DNA using a polymeric vector incorporating endosomolytic oligomeric sulfonamide

(2011) Han Chang Kang et al.   BIOMATERIALS

Enhanced siRNA delivery into cells by exploiting the synergy between targeting ligands and cell-penetrating peptides

(2011) Christopher J. Cheng et al.   BIOMATERIALS

Chitosan-graft-(PEI-β-cyclodextrin) copolymers and their supramolecular PEGylation for DNA and siRNA delivery

(2011) Yuan Ping et al.   BIOMATERIALS

Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity

(2011) Frederico Pittella et al.   BIOMATERIALS

A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy

(2011) Cheng-Qiong Mao et al.   BIOMATERIALS

Polymer therapeutics as nanomedicines: new perspectives

(2011) Ruth Duncan   CURRENT OPINION IN BIOTECHNOLOGY

Inhibitory effect of siRNA complexes with polyamidoamine dendrimer/α-cyclodextrin conjugate (generation 3, G3) on endogenous gene expression

(2011) Hidetoshi Arima et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Co-delivery of anti-vascular endothelial growth factor siRNA and doxorubicin by multifunctional polymeric micelle for tumor growth suppression

(2011) Hong-Yi Huang et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Biophysical characterization of hyper-branched polyethylenimine-graft- polycaprolactone-block-mono-methoxyl-poly(ethylene glycol) copolymers (hy-PEI-PCL-mPEG) for siRNA delivery

(2011) Yu Liu et al.   JOURNAL OF CONTROLLED RELEASE

Anionic polymers for decreased toxicity and enhanced in vivo delivery of siRNA complexed with cationic liposomes

(2011) Anne Schlegel et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis of Poly(propylene glycol)-block-Polyethylenimine Triblock Copolymers for the Delivery of Nucleic Acids

(2011) Blandine Brissault et al.   MACROMOLECULAR BIOSCIENCE

Efficient Intracellular siRNA Delivery by Ethyleneimine-Modified Amphiphilic Macromolecules

(2011) Sarah M. Sparks et al.   MACROMOLECULAR BIOSCIENCE

Impact of Lipid Substitution on Assembly and Delivery of siRNA by Cationic Polymers

(2011) Hamidreza Montazeri Aliabadi et al.   MACROMOLECULAR BIOSCIENCE

Synergistic Induction of Apoptosis in Brain Cancer Cells by Targeted Codelivery of siRNA and Anticancer Drugs

(2011) Cheoljin Kim et al.   MOLECULAR PHARMACEUTICS

Induction of Apoptosis by Survivin Silencing through siRNA Delivery in a Human Breast Cancer Cell Line

(2011) Hamidreza Montazeri Aliabadi et al.   MOLECULAR PHARMACEUTICS

Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery

(2011) Daniel J. Siegwart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly-l-lysine-coated albumin nanoparticles: Stability, mechanism for increasing in vitro enzymatic resilience, and siRNA release characteristics

(2010) Harsh Deep Singh et al.   Acta Biomaterialia

Biochemical Principles of Small RNA Pathways

(2010) Qinghua Liu et al.   Annual Review of Biochemistry

Rational Design of Targeted Cancer Therapeutics through the Multiconjugation of Folate and Cleavable siRNA to RAFT-Synthesized (HPMA-s-APMA) Copolymers†

(2010) Adam W. York et al.   BIOMACROMOLECULES

pH-Responsive Polymeric Micelle Carriers for siRNA Drugs

(2010) A. J. Convertine et al.   BIOMACROMOLECULES

Primary cardiomyocyte-targeted bioreducible polymer for efficient gene delivery to the myocardium

(2010) Hye Y. Nam et al.   BIOMATERIALS

Target specific tumor treatment by VEGF siRNA complexed with reducible polyethyleneimine–hyaluronic acid conjugate

(2010) Kitae Park et al.   BIOMATERIALS

Virus-mimetic polymeric micelles for targeted siRNA delivery

(2010) Xiao-Bing Xiong et al.   BIOMATERIALS

Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system

(2010) Hiroyasu Takemoto et al.   BIOMATERIALS

Degradable, pH-sensitive, membrane-destabilizing, comb-like polymers for intracellular delivery of nucleic acids

(2010) Yen-Ling Lin et al.   BIOMATERIALS

Polymer-related off-target effects in non-viral siRNA delivery

(2010) Olivia M. Merkel et al.   BIOMATERIALS

The synergistic effect of hierarchical assemblies of siRNA and chemotherapeutic drugs co-delivered into hepatic cancer cells

(2010) Nuo Cao et al.   BIOMATERIALS

PAMAM Dendrimers for siRNA Delivery: Computational and Experimental Insights

(2010) Giovanni Maria Pavan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Efficient delivery of intact phosphodiester oligonucleotides by poly-β-amino esters

(2010) K. Remaut et al.   JOURNAL OF CONTROLLED RELEASE

RNA interference in vitro and in vivo using an arginine peptide/siRNA complex system

(2010) Sung Wook Kim et al.   JOURNAL OF CONTROLLED RELEASE

Tumor-homing glycol chitosan/polyethylenimine nanoparticles for the systemic delivery of siRNA in tumor-bearing mice

(2010) Myung Sook Huh et al.   JOURNAL OF CONTROLLED RELEASE

Pegylated poly-l-arginine derivatives of chitosan for effective delivery of siRNA

(2010) Sang Myoung Noh et al.   JOURNAL OF CONTROLLED RELEASE

Efficient siRNA delivery based on PEGylated and partially quaternized polyamine nanogels: Enhanced gene silencing activity by the cooperative effect of tertiary and quaternary amino groups in the core

(2010) Atsushi Tamura et al.   JOURNAL OF CONTROLLED RELEASE

Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown

(2010) Hyun Jin Kim et al.   JOURNAL OF CONTROLLED RELEASE

Oral TNF-α gene silencing using a polymeric microsphere-based delivery system for the treatment of inflammatory bowel disease

(2010) Christina Kriegel et al.   JOURNAL OF CONTROLLED RELEASE

Development of targeted recombinant polymers that can deliver siRNA to the cytoplasm and plasmid DNA to the cell nucleus

(2010) Brenda F. Canine et al.   JOURNAL OF CONTROLLED RELEASE

Endosomal escape pathways for delivery of biologicals

(2010) Amir K. Varkouhi et al.   JOURNAL OF CONTROLLED RELEASE

Bioresponsive hyperbranched polymers for siRNA and miRNA delivery

(2010) Ulrik L. Rahbek et al.   JOURNAL OF DRUG TARGETING

Thermally Triggered Cellular Uptake of Quantum Dots Immobilized with Poly(N-isopropylacrylamide) and Cell Penetrating Peptide

(2010) Chunsoo Kim et al.   LANGMUIR

Novel Oligonucleotide Carrier as Scavenger for Reactive Oxygen Species

(2010) Yutaka Ikeda et al.   MACROMOLECULAR BIOSCIENCE

Reductive Degradation Behavior of Bioreducible Poly(disulfide amine) for Enhancing SiRNA Efficiency

(2010) Sun Hwa Kim et al.   MACROMOLECULAR BIOSCIENCE

pH-Responsive Polymeric siRNA Carriers Sensitize Multidrug Resistant Ovarian Cancer Cells to Doxorubicin via Knockdown of Polo-like Kinase 1

(2010) Danielle S. W. Benoit et al.   MOLECULAR PHARMACEUTICS

Leukemia-specific siRNA delivery by immunonanoplexes consisting of anti-JL1 minibody conjugated to oligo-9 Arg-peptides

(2010) Yeon Kyung Lee et al.   MOLECULES AND CELLS

Chitosan/siRNA Nanoparticles Biofunctionalize Nerve Implants and Enable Neurite Outgrowth

(2010) Ursula Mittnacht et al.   NANO LETTERS

Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

(2010) D. Scott Wilson et al.   NATURE MATERIALS

Amine-Modified Poly(Vinyl Alcohol)s as Non-viral Vectors for siRNA Delivery: Effects of the Degree of Amine Substitution on Physicochemical Properties and Knockdown Efficiency

(2010) Juliane Nguyen et al.   PHARMACEUTICAL RESEARCH

Functional modification of amide-crosslinked oligoethylenimine for improved siRNA delivery

(2010) Alexander Philipp et al.   REACTIVE & FUNCTIONAL POLYMERS

siRNA delivery systems for cancer treatment

(2009) Yu-Kyoung Oh et al.   ADVANCED DRUG DELIVERY REVIEWS

Enhanced Cytoplasmic Delivery of siRNA Using a Stabilized Polyion Complex Based on PEGylated Nanogels with a Cross-Linked Polyamine Structure

(2009) Atsushi Tamura et al.   BIOMACROMOLECULES

Development of a Functionalized Polymer for Stent Coating in the Arterial Delivery of Small Interfering RNA

(2009) Aurélie San Juan et al.   BIOMACROMOLECULES

In-situ crosslinking hydrogels for combinatorial delivery of chemokines and siRNA–DNA carrying microparticles to dendritic cells

(2009) Ankur Singh et al.   BIOMATERIALS

Targeted intracellular codelivery of chemotherapeutics and nucleic acid with a well-defined dendrimer-based nanoglobular carrier

(2009) Todd L. Kaneshiro et al.   BIOMATERIALS

The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine

(2009) Aws Alshamsan et al.   BIOMATERIALS

Silencing of proinflammatory genes targeted to peritoneal-residing macrophages using siRNA encapsulated in biodegradable microspheres

(2009) Tali Brunner et al.   BIOMATERIALS

Chitosan-graft-polyethylenimine for Akt1 siRNA delivery to lung cancer cells

(2009) Dhananjay Jere et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Preparation and characterization of poly(dl-lactide-co-glycolide) nanoparticles for siRNA delivery

(2009) Dongmei Cun et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Efficient intracellular siRNA delivery strategy through rapid and simple two steps mixing involving noncovalent post-PEGylation

(2009) Won-Ho Kong et al.   JOURNAL OF CONTROLLED RELEASE

Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel

(2009) Changxing Liu et al.   JOURNAL OF CONTROLLED RELEASE

Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging

(2009) Olivia M. Merkel et al.   JOURNAL OF CONTROLLED RELEASE

Anionic amino acid-derived cationic lipid for siRNA delivery

(2009) Min Sung Suh et al.   JOURNAL OF CONTROLLED RELEASE

Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy

(2009) Kevin Buyens et al.   JOURNAL OF CONTROLLED RELEASE

Stability and cellular uptake of polymerized siRNA (poly-siRNA)/polyethylenimine (PEI) complexes for efficient gene silencing

(2009) Seung-Young Lee et al.   JOURNAL OF CONTROLLED RELEASE

Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation

(2009) Ditte Marie Krohn Jensen et al.   JOURNAL OF CONTROLLED RELEASE

Reversibly crosslinked temperature-responsive nano-sized polymersomes: synthesis and triggered drug release

(2009) Haifei Xu et al.   JOURNAL OF MATERIALS CHEMISTRY

Access to Poly-β-Peptides with Functionalized Side Chains and End Groups via Controlled Ring-Opening Polymerization of β-Lactams

(2009) Jihua Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA−Polymer Conjugate

(2009) Martin Meyer et al.   MOLECULAR PHARMACEUTICS

Old polymer learns new tracts

(2009) Michael J. Campolongo et al.   NATURE MATERIALS

Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA

(2009) Kim A. Woodrow et al.   NATURE MATERIALS

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Nanosized polyamidoamine (PAMAM) dendrimer-induced apoptosis mediated by mitochondrial dysfunction

(2009) Jong-Ho Lee et al.   TOXICOLOGY LETTERS

siRNA Conjugate Delivery Systems

(2008) Ji Hoon Jeong et al.   BIOCONJUGATE CHEMISTRY

Physicochemical Characteristics and Preliminary in Vivo Biological Evaluation of Nanocapsules Loaded with siRNA Targeting Estrogen Receptor Alpha

(2008) Céline Bouclier et al.   BIOMACROMOLECULES

Environment-Responsive Block Copolymer Micelles with a Disulfide Cross-Linked Core for Enhanced siRNA Delivery

(2008) Satoru Matsumoto et al.   BIOMACROMOLECULES

Cardiomyocyte-targeted siRNA delivery by prostaglandin E2-Fas siRNA polyplexes formulated with reducible poly(amido amine) for preventing cardiomyocyte apoptosis

(2008) Sun Hwa Kim et al.   BIOMATERIALS

Poly(β-amino ester) as a carrier for si/shRNA delivery in lung cancer cells

(2008) Dhananjay Jere et al.   BIOMATERIALS

Progress in developing cationic vectors for non-viral systemic gene therapy against cancer

(2008) Marie Morille et al.   BIOMATERIALS

Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery

(2008) Tian-Meng Sun et al.   BIOMATERIALS

Akt1 silencing efficiencies in lung cancer cells by sh/si/ssiRNA transfection using a reductable polyspermine carrier

(2008) Dhananjay Jere et al.   BIOMATERIALS

Biodegradable amphiphilic poly(ethylene oxide)-block-polyesters with grafted polyamines as supramolecular nanocarriers for efficient siRNA delivery

(2008) Xiao-Bing Xiong et al.   BIOMATERIALS

Nonviral Vectors for Gene Delivery

(2008) Meredith A. Mintzer et al.   CHEMICAL REVIEWS

Cellular Delivery In Vivo of siRNA-Based Therapeutics

(2008) A. Aigner   CURRENT PHARMACEUTICAL DESIGN

State of the art and perspectives for the delivery of antisense oligonucleotides and siRNA by polymeric nanocarriers

(2008) Elias Fattal et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Preparation of polyethyleneimine incorporated poly(d,l-lactide-co-glycolide) nanoparticles by spontaneous emulsion diffusion method for small interfering RNA delivery

(2008) Haliza Katas et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent liposomes

(2008) D AUGUSTE et al.   JOURNAL OF CONTROLLED RELEASE

Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy

(2008) Juliane Nguyen et al.   JOURNAL OF CONTROLLED RELEASE

A peptide-targeted delivery system with pH-sensitive amphiphilic cell membrane disruption for efficient receptor-mediated siRNA delivery

(2008) Xu-Li Wang et al.   JOURNAL OF CONTROLLED RELEASE

Development of a novel endosomolytic diblock copolymer for siRNA delivery

(2008) Anthony J. Convertine et al.   JOURNAL OF CONTROLLED RELEASE

Polymersome delivery of siRNA and antisense oligonucleotides

(2008) Younghoon Kim et al.   JOURNAL OF CONTROLLED RELEASE

Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(β‐amino esters)

(2008) Roosmarijn E. Vandenbroucke et al.   JOURNAL OF GENE MEDICINE

Breathing Life into Polycations:  Functionalization with pH-Responsive Endosomolytic Peptides and Polyethylene Glycol Enables siRNA Delivery

(2008) Martin Meyer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis, Transport and Pharmacokinetics of 5′-Amino Acid Ester Prodrugs of 1-β-d-Arabinofuranosylcytosine

(2008) Yongbing Sun et al.   MOLECULAR PHARMACEUTICS

Delivery of siRNA from lyophilized polymeric surfaces

(2007) Morten Ø. Andersen et al.   BIOMATERIALS

A multifunctional and reversibly polymerizable carrier for efficient siRNA delivery

(2007) Xu-Li Wang et al.   BIOMATERIALS

Thermally sensitive cationic polymer nanocapsules for specific cytosolic delivery and efficient gene silencing of siRNA: Swelling induced physical disruption of endosome by cold shock

(2007) Soo Hyeon Lee et al.   JOURNAL OF CONTROLLED RELEASE

Breaking the Bonds: Non-viral Vectors Become Chemically Dynamic

(2007) Jon A Wolff et al.   MOLECULAR THERAPY