Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells

In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

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The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy

(2016) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

(2015) Eugen Rempel et al.   ARCHIVES OF TOXICOLOGY

Genome-wide copy number variant analysis for congenital ventricular septal defects in Chinese Han population

(2015) Yu An et al.   BMC Medical Genomics

Claudin-10 is required for relay of left–right patterning cues from Hensen’s node to the lateral plate mesoderm

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Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells

(2015) K Meganathan et al.   Cell Death & Disease

From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects

(2014) Nina V. Balmer et al.   ARCHIVES OF TOXICOLOGY

CellNet: Network Biology Applied to Stem Cell Engineering

(2014) Patrick Cahan et al.   CELL

Test systems of developmental toxicity: state-of-the art and future perspectives

(2013) Marcel Leist et al.   ARCHIVES OF TOXICOLOGY

Toward a 3D model of human brain development for studying gene/environment interactions

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Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

(2012) Anne K. Krug et al.   ARCHIVES OF TOXICOLOGY

Disclosure of grounds of European withdrawn and refused applications: a step forward on regulatory transparency

(2012) Giovanni Tafuri et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Role of Histone Acetylation in the Stimulatory Effect of Valproic Acid on Vascular Endothelial Tissue-Type Plasminogen Activator Expression

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Identification of Thalidomide-Specific Transcriptomics and Proteomics Signatures during Differentiation of Human Embryonic Stem Cells

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Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

(2011) Sarah Adler et al.   ARCHIVES OF TOXICOLOGY

Opportunities for Use of Human iPS Cells in Predictive Toxicology

(2011) B D Anson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Concise Review: Induced Pluripotent Stem Cells Versus Embryonic Stem Cells: Close Enough or Yet Too Far Apart?

(2011) Josipa Bilic et al.   STEM CELLS

Induced Pluripotent Stem Cells as a Model for Accelerated Patient- and Disease-specific Drug Discovery

(2010) I. Gunaseeli et al.   CURRENT MEDICINAL CHEMISTRY

The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform

(2010) Sunita J. Shukla et al.   DRUG DISCOVERY TODAY

Valproic Acid Monotherapy in Pregnancy and Major Congenital Malformations

(2010) Janneke Jentink et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biochemical, Molecular and Epigenetic Mechanisms of Valproic Acid Neuroprotection

(2010) Barbara Monti et al.   Current Molecular Pharmacology

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Are In Vitro Tests Suitable for Regulatory Use?

(2009) Thomas Hartung et al.   TOXICOLOGICAL SCIENCES

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH